ParkinsonCanadaV1, Main, Exploration, bibRecord, 003077

Increase in dopamine turnover occurs early in Parkinson's disease: Evidence from a new modeling approach to PET 18F-fluorodopa data

Identifieur interne : 003077 ( Main/Exploration ); précédent : 003076; suivant : 003078

Increase in dopamine turnover occurs early in Parkinson's disease: Evidence from a new modeling approach to PET 18F-fluorodopa data

Auteurs : Vesna Sossi [Canada] ; Raul De La Fuente-Fernandez [Canada] ; James E. Holden [États-Unis] ; Doris J. Doudet [Canada] ; Jess Mckenzie [Canada] ; A. J. Stoessl [Canada] ; T. J. Ruth [Canada]

Source :

Journal of cerebral blood flow and metabolism [ 0271-678X ] ; 2002.

RBID : Pascal:02-0186887

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Tomoscintigraphie, Positon, Fluorodopa(18F), Turnover, Dopamine, Modélisation, Technique, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Brain (diagnostic imaging), Brain (metabolism), Dihydroxyphenylalanine (analogs & derivatives), Discriminant Analysis, Dopamine, Dopamine (metabolism), Emission tomography, Exploration, Female, Fluorine Radioisotopes, Fluorodopa(18F), Human, Humans, Male, Middle Aged, Modeling, Models, Biological, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson disease, Positron, Technique, Tomography, Emission-Computed, Turnover.
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- diagnostic imaging : Brain, Parkinson Disease.
- metabolism : Brain, Dopamine, Parkinson Disease.
- Aged, Discriminant Analysis, Female, Fluorine Radioisotopes, Humans, Male, Middle Aged, Models, Biological, Tomography, Emission-Computed.

Abstract

An increase in dopamine turnover has been hypothesized to occur early in Parkinson's disease (PD) as a compensatory mechanism for dopaminergic neuronal loss. A new approach to the determination of dopamine turnover was developed using 4-hour-long ¹⁸F-fluorodopa (FD) positron emission tomography (PET) data. An effective dopamine turnover, an estimate of dopamine turnover, has been measured using its inverse, the effective dopamine distribution volume (EDV). This new method is based on a reversible tracer approach and determines the EDV using a graphical method. Six healthy subjects and 10 subjects with very early PD underwent a 4-hour-long FD scan. The EDV and the plasma uptake rate constant K_i, a marker of dopamine synthesis and storage, were compared according to their ability to separate the PD group from the healthy group. The EDV was the better discriminator (93.8% correct classification versus 81.3% for Kj). Effective dopamine distribution volume decreased by 65% in the PD group relative to the healthy group, whereas the decrease in K_i was 39%. These results show that changes in EDV are measurable with PET earlier than changes in the dopamine synthesis and storage rate, indicating that EDV is a sensitive marker for early PD and that a dopamine turnover increase likely serves as an early compensatory mechanism.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">An increase in dopamine turnover has been hypothesized to occur early in Parkinson's disease (PD) as a compensatory mechanism for dopaminergic neuronal loss. A new approach to the determination of dopamine turnover was developed using 4-hour-long <sup>18</sup>
F-fluorodopa (FD) positron emission tomography (PET) data. An effective dopamine turnover, an estimate of dopamine turnover, has been measured using its inverse, the effective dopamine distribution volume (EDV). This new method is based on a reversible tracer approach and determines the EDV using a graphical method. Six healthy subjects and 10 subjects with very early PD underwent a 4-hour-long FD scan. The EDV and the plasma uptake rate constant K<sub>i</sub>
, a marker of dopamine synthesis and storage, were compared according to their ability to separate the PD group from the healthy group. The EDV was the better discriminator (93.8% correct classification versus 81.3% for Kj). Effective dopamine distribution volume decreased by 65% in the PD group relative to the healthy group, whereas the decrease in K<sub>i</sub>
 was 39%. These results show that changes in EDV are measurable with PET earlier than changes in the dopamine synthesis and storage rate, indicating that EDV is a sensitive marker for early PD and that a dopamine turnover increase likely serves as an early compensatory mechanism.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Increase in dopamine turnover occurs early in Parkinson's disease: Evidence from a new modeling approach to PET 18F-fluorodopa data

Increase in dopamine turnover occurs early in Parkinson's disease: Evidence from a new modeling approach to PET 18F-fluorodopa data

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.