ParkinsonCanadaV1, Main, Exploration, bibRecord, 002C92

Tremor cells in the human thalamus: differences among neurological disorders

Identifieur interne : 002C92 ( Main/Exploration ); précédent : 002C91; suivant : 002C93

Tremor cells in the human thalamus: differences among neurological disorders

Auteurs : Jason A. Brodkey [Canada] ; Ronald R. Tasker ; Clement Hamani ; Mary Pat Mcandrews ; Jonathan O. Dostrovsky ; Andres M. Lozano

Source :

Journal of neurosurgery [ 0022-3085 ] ; 2004.

RBID : Pascal:04-0372901

Descripteurs français

Pascal (Inist)
- Tremblement, Homme, Thalamus, Trouble neurologique, Chirurgie, Parkinson maladie, Système nerveux pathologie, Traitement.
Wicri :
- topic : Homme, Chirurgie.

English descriptors

KwdEn :
- Adult, Cerebellar Diseases (complications), Cerebellar Diseases (pathology), Cerebellar Diseases (physiopathology), Essential Tremor (pathology), Essential Tremor (physiopathology), Evoked Potentials, Female, Human, Humans, Male, Microelectrodes, Middle Aged, Multiple Sclerosis (complications), Multiple Sclerosis (pathology), Multiple Sclerosis (physiopathology), Nervous system diseases, Neurological disorder, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Retrospective Studies, Surgery, Thalamus, Thalamus (pathology), Thalamus (physiopathology), Treatment, Tremor, Tremor (etiology), Tremor (pathology), Tremor (physiopathology).
MESH :
- complications : Cerebellar Diseases, Multiple Sclerosis, Parkinson Disease.
- etiology : Tremor.
- pathology : Cerebellar Diseases, Essential Tremor, Multiple Sclerosis, Parkinson Disease, Thalamus, Tremor.
- physiopathology : Cerebellar Diseases, Essential Tremor, Multiple Sclerosis, Parkinson Disease, Thalamus, Tremor.
- Adult, Evoked Potentials, Female, Humans, Male, Microelectrodes, Middle Aged, Retrospective Studies.

Abstract

Object. Thalamic neurons firing at frequencies synchronous with tremor are thought to play a critical role in the generation and maintenance of tremor. The authors studied the incidence and locations of neurons with tremor-related activity (TRA) in the thalamus of patients with varied pathological conditions-including Parkinson disease (PD), essential tremor (ET), multiple sclerosis (MS), and cerebellar disorders-to determine whether known differences in the effectiveness of thalamic stereotactic procedures for these tremors could be correlated to differences in the incidence or locations of TRA cells. Methods. Seventy-five operations were performed in 61 patients during which 686 TRA cells were recorded from 440 microelectrode trajectories in the thalamus. The locations of the TRA cells in relation to electrophysiologically defined thalamic nuclei and the commissural coordinates were compared among patient groups. The authors found that TRA cells are present in patients with each of these disorders and that these cells populate several nuclei in the ventral lateral tier of the thalamus. There were no large differences in the locations of TRA cells among the different diagnostic classes, although there was a difference in the incidence of TRA cells in patients with PD, who had greater than 3.8 times more cells per thalamic trajectory than patients with ET and approximately five times more cells than patients with MS or cerebellar disorders. Conclusions. There was an increased incidence of TRA in the thalamus of patients with PD. The location of thalamic TRA cells in patients with basal ganglia and other tremor disorders was similar.

Affiliations:

Le document en format XML

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<term>Cerebellar Diseases (physiopathology)</term>
<term>Essential Tremor (pathology)</term>
<term>Essential Tremor (physiopathology)</term>
<term>Evoked Potentials</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (complications)</term>
<term>Multiple Sclerosis (pathology)</term>
<term>Multiple Sclerosis (physiopathology)</term>
<term>Nervous system diseases</term>
<term>Neurological disorder</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Retrospective Studies</term>
<term>Surgery</term>
<term>Thalamus</term>
<term>Thalamus (pathology)</term>
<term>Thalamus (physiopathology)</term>
<term>Treatment</term>
<term>Tremor</term>
<term>Tremor (etiology)</term>
<term>Tremor (pathology)</term>
<term>Tremor (physiopathology)</term>
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<term>Multiple Sclerosis</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellar Diseases</term>
<term>Essential Tremor</term>
<term>Multiple Sclerosis</term>
<term>Parkinson Disease</term>
<term>Thalamus</term>
<term>Tremor</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term>
<term>Essential Tremor</term>
<term>Multiple Sclerosis</term>
<term>Parkinson Disease</term>
<term>Thalamus</term>
<term>Tremor</term>
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<term>Evoked Potentials</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<term>Homme</term>
<term>Thalamus</term>
<term>Trouble neurologique</term>
<term>Chirurgie</term>
<term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Object. Thalamic neurons firing at frequencies synchronous with tremor are thought to play a critical role in the generation and maintenance of tremor. The authors studied the incidence and locations of neurons with tremor-related activity (TRA) in the thalamus of patients with varied pathological conditions-including Parkinson disease (PD), essential tremor (ET), multiple sclerosis (MS), and cerebellar disorders-to determine whether known differences in the effectiveness of thalamic stereotactic procedures for these tremors could be correlated to differences in the incidence or locations of TRA cells. Methods. Seventy-five operations were performed in 61 patients during which 686 TRA cells were recorded from 440 microelectrode trajectories in the thalamus. The locations of the TRA cells in relation to electrophysiologically defined thalamic nuclei and the commissural coordinates were compared among patient groups. The authors found that TRA cells are present in patients with each of these disorders and that these cells populate several nuclei in the ventral lateral tier of the thalamus. There were no large differences in the locations of TRA cells among the different diagnostic classes, although there was a difference in the incidence of TRA cells in patients with PD, who had greater than 3.8 times more cells per thalamic trajectory than patients with ET and approximately five times more cells than patients with MS or cerebellar disorders. Conclusions. There was an increased incidence of TRA in the thalamus of patients with PD. The location of thalamic TRA cells in patients with basal ganglia and other tremor disorders was similar.</div>
</front>
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<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Tremor cells in the human thalamus: differences among neurological disorders

Tremor cells in the human thalamus: differences among neurological disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.