X-ray fluorescence spectrometry, an analytical tool in neurochemical research
Identifieur interne : 002369 ( Main/Exploration ); précédent : 002368; suivant : 002370X-ray fluorescence spectrometry, an analytical tool in neurochemical research
Auteurs : Magdalena Szczerbowska-Boruchowska [Pologne]Source :
- X-ray spectrometry [ 0049-8246 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Valence (Drôme).
- topic : Plomb, Analyse quantitative, Homme.
English descriptors
- KwdEn :
Abstract
The central nervous system (CNS) is undoubtedly the most complex structure in the human body. Metal ions play an important role in the normal functioning of this organ. Disturbances of metal ion homeostasis may lead to serious diseases of CNS. On the other hand, the abnormal accumulation of selected elements may be a result of pathological processes. The application of different analytical techniques to the determination of the normal and pathological accumulation of trace elements in human CNS tissue has proved to be popular in recent years. A review of current analytical activity for human CNS tissue is presented. Special attention is paid to the remarkable opportunities provided by using synchrotron radiation in elemental analysis. The results of application of synchrotron radiation x-ray fluorescence (SRXRF) as well as x-ray absorption near-edge structure (XANES) spectroscopy to investigate Parkinson's disease, amiotrophic lateral sclerosis and brain gliomas are shown. Topographic and quantitative analysis with the use of SRXRF allows the determination of minor and trace elements in thin tissue samples of human CNS at the single-cell level. The comparison between these pathological cases and control group pointed out differences in elemental composition of the tissues. Moreover, application of XANES spectroscopy made it possible to determine oxidation states of Fe and S in Parkinson-diseased tissue and brain gliomas.
Affiliations:
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Le document en format XML
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Mickiewicza 30</s1><s2>30-059 Krakow</s2><s3>POL</s3><sZ>1 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>30-059 Krakow</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0280983</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0280983 INIST</idno><idno type="RBID">Pascal:08-0280983</idno><idno type="wicri:Area/PascalFrancis/Corpus">000645</idno><idno type="wicri:Area/PascalFrancis/Curation">000665</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000503</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000503</idno><idno type="wicri:doubleKey">0049-8246:2008:Szczerbowska Boruchowska M:x:ray:fluorescence</idno><idno type="wicri:Area/Main/Merge">002564</idno><idno type="wicri:Area/Main/Curation">002369</idno><idno type="wicri:Area/Main/Exploration">002369</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">X-ray fluorescence spectrometry, an analytical tool in neurochemical research</title><author><name sortKey="Szczerbowska Boruchowska, Magdalena" sort="Szczerbowska Boruchowska, Magdalena" uniqKey="Szczerbowska Boruchowska M" first="Magdalena" last="Szczerbowska-Boruchowska">Magdalena Szczerbowska-Boruchowska</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30</s1><s2>30-059 Krakow</s2><s3>POL</s3><sZ>1 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>30-059 Krakow</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">X-ray spectrometry</title><title level="j" type="abbreviated">X-ray spectrom.</title><idno type="ISSN">0049-8246</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">X-ray spectrometry</title><title level="j" type="abbreviated">X-ray spectrom.</title><idno type="ISSN">0049-8246</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term><term>Elementary analysis</term><term>Human</term><term>Lead</term><term>Metal ion</term><term>Minor element</term><term>Quantitative analysis</term><term>Review</term><term>Synchrotron radiation</term><term>Tissue</term><term>Trace element</term><term>Valence</term><term>X ray absorption spectrometry</term><term>X ray fluorescence spectrometry</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Spectrométrie fluorescence RX</term><term>Ion métallique</term><term>Plomb</term><term>Elément trace</term><term>Article synthèse</term><term>Rayonnement synchrotron</term><term>Analyse élémentaire</term><term>Spectrométrie absorption RX</term><term>Analyse quantitative</term><term>Elément mineur</term><term>Etude comparative</term><term>Valence</term><term>Homme</term><term>Tissu</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Valence (Drôme)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plomb</term><term>Analyse quantitative</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The central nervous system (CNS) is undoubtedly the most complex structure in the human body. Metal ions play an important role in the normal functioning of this organ. Disturbances of metal ion homeostasis may lead to serious diseases of CNS. On the other hand, the abnormal accumulation of selected elements may be a result of pathological processes. The application of different analytical techniques to the determination of the normal and pathological accumulation of trace elements in human CNS tissue has proved to be popular in recent years. A review of current analytical activity for human CNS tissue is presented. Special attention is paid to the remarkable opportunities provided by using synchrotron radiation in elemental analysis. The results of application of synchrotron radiation x-ray fluorescence (SRXRF) as well as x-ray absorption near-edge structure (XANES) spectroscopy to investigate Parkinson's disease, amiotrophic lateral sclerosis and brain gliomas are shown. Topographic and quantitative analysis with the use of SRXRF allows the determination of minor and trace elements in thin tissue samples of human CNS at the single-cell level. The comparison between these pathological cases and control group pointed out differences in elemental composition of the tissues. Moreover, application of XANES spectroscopy made it possible to determine oxidation states of Fe and S in Parkinson-diseased tissue and brain gliomas.</div></front></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Szczerbowska Boruchowska, Magdalena" sort="Szczerbowska Boruchowska, Magdalena" uniqKey="Szczerbowska Boruchowska M" first="Magdalena" last="Szczerbowska-Boruchowska">Magdalena Szczerbowska-Boruchowska</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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