ParkinsonCanadaV1, Main, Exploration, bibRecord, 002221

Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease.

Identifieur interne : 002221 ( Main/Exploration ); précédent : 002220; suivant : 002222

Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease.

Auteurs : Thomas P. Bouchard [Canada] ; Nikolai Malykhin ; W R Wayne Martin ; Christopher C. Hanstock ; Derek J. Emery ; Nancy J. Fisher ; Richard M. Camicioli

Source :

Neurobiology of aging [ 1558-1497 ] ; 2008.

RBID : pubmed:17368653

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (pathology), Amygdala (pathology), Atrophy (pathology), Dementia (complications), Dementia (pathology), Female, Hippocampus (pathology), Humans, Magnetic Resonance Imaging (methods), Male, Parkinson Disease (complications), Parkinson Disease (pathology).
MESH :
- complications : Dementia, Parkinson Disease.
- methods : Magnetic Resonance Imaging.
- pathology : Aging, Amygdala, Atrophy, Dementia, Hippocampus, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male.

Abstract

The hippocampus (HC) and amygdala (AG) decrease in volume with age and in Parkinson's disease (PD) with (PDD) and without dementia. We compared 44 PD to 44 age, sex and education-matched subjects without PD (non-PD) and 13 PDD subjects. T1-weighted MR images were used to manually segment the head, body and tail of the HC and the AG. HC volumes, corrected to intracranial volume, were smaller in PDD than non-PD (p=0.04), reflected predominantly by head atrophy. Right AG volumes were smaller in PD compared to non-PD (p=0.03). HC volumes in older (>70), but not younger, non-demented PD differed from non-PD (HC, p=0.02; head, p=0.03). Age correlated negatively with overall HC (r=-0.43, p=0.004) and head (r=-0.48, p=0.001) in PD, but not in non-PD. In PD, left HC head volumes correlated with recall, but not recognition scores on the CVLT-II (r=0.35, p=0.02) and BVMT-R (r=0.35, p=0.02); AG volumes correlated with CVLT-II recall (r=0.35, p=0.02). No correlations were found in non-PD (p>0.4). In conclusion, functionally meaningful age-associated hippocampal and amygdala atrophy occurs in PD.

DOI: 10.1016/j.neurobiolaging.2007.02.002
PubMed: 17368653

Affiliations:

Canada

Le document en format XML

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<author><name sortKey="Fisher, Nancy J" sort="Fisher, Nancy J" uniqKey="Fisher N" first="Nancy J" last="Fisher">Nancy J. Fisher</name>
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<author><name sortKey="Camicioli, Richard M" sort="Camicioli, Richard M" uniqKey="Camicioli R" first="Richard M" last="Camicioli">Richard M. Camicioli</name>
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<term>Atrophy (pathology)</term>
<term>Dementia (complications)</term>
<term>Dementia (pathology)</term>
<term>Female</term>
<term>Hippocampus (pathology)</term>
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<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
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<term>Atrophy</term>
<term>Dementia</term>
<term>Hippocampus</term>
<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">The hippocampus (HC) and amygdala (AG) decrease in volume with age and in Parkinson's disease (PD) with (PDD) and without dementia. We compared 44 PD to 44 age, sex and education-matched subjects without PD (non-PD) and 13 PDD subjects. T1-weighted MR images were used to manually segment the head, body and tail of the HC and the AG. HC volumes, corrected to intracranial volume, were smaller in PDD than non-PD (p=0.04), reflected predominantly by head atrophy. Right AG volumes were smaller in PD compared to non-PD (p=0.03). HC volumes in older (>70), but not younger, non-demented PD differed from non-PD (HC, p=0.02; head, p=0.03). Age correlated negatively with overall HC (r=-0.43, p=0.004) and head (r=-0.48, p=0.001) in PD, but not in non-PD. In PD, left HC head volumes correlated with recall, but not recognition scores on the CVLT-II (r=0.35, p=0.02) and BVMT-R (r=0.35, p=0.02); AG volumes correlated with CVLT-II recall (r=0.35, p=0.02). No correlations were found in non-PD (p>0.4). In conclusion, functionally meaningful age-associated hippocampal and amygdala atrophy occurs in PD.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease.

Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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