Haplotypes and gene expression implicate the MAPT region for Parkinson disease
Identifieur interne : 002185 ( Main/Exploration ); précédent : 002184; suivant : 002186Haplotypes and gene expression implicate the MAPT region for Parkinson disease
Auteurs : J. E. Tobin ; J. C. Latourelle ; M. F. Lew ; C. Klein ; O. Suchowersky ; H. A. Shill ; L. I. Golbe ; M. H. Mark ; J. H. Growdon ; G. F. Wooten ; B. A. Racette ; J. S. Perlmutter ; R. Watts ; M. Guttman ; K. B. Baker ; S. Goldwurm ; G. Pezzoli ; C. Singer ; M. H. Saint-Hilaire ; A. E. Hendricks ; S. Williamson ; M. W. Nagle ; J. B. Wilk ; T. Massood ; J. M. Laramie ; A. L. Destefano ; I. Litvan ; G. Nicholson ; A. Corbett ; S. Isaacson ; D. J. Burn ; P. F. Chinnery ; P. P. Pramstaller ; S. Sherman ; J. Al-Hinti ; E. Drasby ; M. Nance ; A. T. Moller ; K. Ostergaard ; R. Roxburgh ; B. Snow ; J. T. Slevin ; F. Cambi ; J. F. Gusella ; R. H. MyersSource :
- Neurology [ 0028-3878 ] ; 2008.
Abstract
Microtubule-associated protein tau (
Twenty-one single-nucleotide polymorphisms (SNPs) in the region of
After adjusting for multiple comparisons, SNP rs1800547 was significantly associated with PD affection. While the H1 haplotype was associated with a significantly increased risk for PD, a novel H1 subhaplotype was identified that predicted a greater increased risk for PD. The expression of 4-repeat
This study supports a role for
Url:
DOI: 10.1212/01.wnl.0000304051.01650.23
PubMed: 18509094
PubMed Central: 2654275
Affiliations:
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E." last="Tobin">J. E. Tobin</name></author><author><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name></author><author><name sortKey="Lew, M F" sort="Lew, M F" uniqKey="Lew M" first="M. F." last="Lew">M. F. Lew</name></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name></author><author><name sortKey="Shill, H A" sort="Shill, H A" uniqKey="Shill H" first="H. A." last="Shill">H. A. Shill</name></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name></author><author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name></author><author><name sortKey="Growdon, J H" sort="Growdon, J H" uniqKey="Growdon J" first="J. H." last="Growdon">J. H. Growdon</name></author><author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></author><author><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name></author><author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name></author><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></author><author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name></author><author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name></author><author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Saint Hilaire, M H" sort="Saint Hilaire, M H" uniqKey="Saint Hilaire M" first="M. H." last="Saint-Hilaire">M. H. Saint-Hilaire</name></author><author><name sortKey="Hendricks, A E" sort="Hendricks, A E" uniqKey="Hendricks A" first="A. E." last="Hendricks">A. E. Hendricks</name></author><author><name sortKey="Williamson, S" sort="Williamson, S" uniqKey="Williamson S" first="S." last="Williamson">S. Williamson</name></author><author><name sortKey="Nagle, M W" sort="Nagle, M W" uniqKey="Nagle M" first="M. W." last="Nagle">M. W. Nagle</name></author><author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name></author><author><name sortKey="Massood, T" sort="Massood, T" uniqKey="Massood T" first="T." last="Massood">T. Massood</name></author><author><name sortKey="Laramie, J M" sort="Laramie, J M" uniqKey="Laramie J" first="J. M." last="Laramie">J. M. Laramie</name></author><author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name></author><author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name></author><author><name sortKey="Corbett, A" sort="Corbett, A" uniqKey="Corbett A" first="A." last="Corbett">A. Corbett</name></author><author><name sortKey="Isaacson, S" sort="Isaacson, S" uniqKey="Isaacson S" first="S." last="Isaacson">S. Isaacson</name></author><author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name></author><author><name sortKey="Chinnery, P F" sort="Chinnery, P F" uniqKey="Chinnery P" first="P. F." last="Chinnery">P. F. Chinnery</name></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></author><author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name></author><author><name sortKey="Al Hinti, J" sort="Al Hinti, J" uniqKey="Al Hinti J" first="J." last="Al-Hinti">J. Al-Hinti</name></author><author><name sortKey="Drasby, E" sort="Drasby, E" uniqKey="Drasby E" first="E." last="Drasby">E. Drasby</name></author><author><name sortKey="Nance, M" sort="Nance, M" uniqKey="Nance M" first="M." last="Nance">M. Nance</name></author><author><name sortKey="Moller, A T" sort="Moller, A T" uniqKey="Moller A" first="A. T." last="Moller">A. T. Moller</name></author><author><name sortKey="Ostergaard, K" sort="Ostergaard, K" uniqKey="Ostergaard K" first="K." last="Ostergaard">K. Ostergaard</name></author><author><name sortKey="Roxburgh, R" sort="Roxburgh, R" uniqKey="Roxburgh R" first="R." last="Roxburgh">R. Roxburgh</name></author><author><name sortKey="Snow, B" sort="Snow, B" uniqKey="Snow B" first="B." last="Snow">B. Snow</name></author><author><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name></author><author><name sortKey="Cambi, F" sort="Cambi, F" uniqKey="Cambi F" first="F." last="Cambi">F. Cambi</name></author><author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Microtubule-associated protein tau (<italic>MAPT</italic>) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association of the <italic>MAPT</italic> region with PD in a large cohort of familial PD cases recruited by the <italic>Gene</italic>PD Study. In addition, postmortem brain samples from patients with PD and neurologically normal controls were used to evaluate whether the expression of the 3-repeat and 4-repeat isoforms of <italic>MAPT</italic>, and neighboring genes Saitohin (<italic>STH</italic>) and <italic>KIAA1267</italic>, are altered in PD cerebellum.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Twenty-one single-nucleotide polymorphisms (SNPs) in the region of <italic>MAPT</italic> on chromosome 17q21 were genotyped in the <italic>Gene</italic>PD Study. Single SNPs and haplotypes, including the H1 haplotype, were evaluated for association to PD. Relative quantification of gene expression was performed using real-time RT-PCR.</p></sec><sec id="S3"><title>Results</title><p id="P3">After adjusting for multiple comparisons, SNP rs1800547 was significantly associated with PD affection. While the H1 haplotype was associated with a significantly increased risk for PD, a novel H1 subhaplotype was identified that predicted a greater increased risk for PD. The expression of 4-repeat <italic>MAPT, STH</italic>, and <italic>KIAA1267</italic> was significantly increased in PD brains relative to controls. No difference in expression was observed for 3-repeat <italic>MAPT</italic>.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">This study supports a role for <italic>MAPT</italic> in the pathogenesis of familial and idiopathic Parkinson disease (PD). Interestingly, the results of the gene expression studies suggest that other genes in the vicinity of <italic>MAPT</italic>, specifically <italic>STH</italic> and <italic>KIAA1267</italic>, may also have a role in PD and suggest complex effects for the genes in this region on PD risk.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Al Hinti, J" sort="Al Hinti, J" uniqKey="Al Hinti J" first="J." last="Al-Hinti">J. Al-Hinti</name><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name><name sortKey="Cambi, F" sort="Cambi, F" uniqKey="Cambi F" first="F." last="Cambi">F. Cambi</name><name sortKey="Chinnery, P F" sort="Chinnery, P F" uniqKey="Chinnery P" first="P. F." last="Chinnery">P. F. Chinnery</name><name sortKey="Corbett, A" sort="Corbett, A" uniqKey="Corbett A" first="A." last="Corbett">A. Corbett</name><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name><name sortKey="Drasby, E" sort="Drasby, E" uniqKey="Drasby E" first="E." last="Drasby">E. Drasby</name><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name><name sortKey="Growdon, J H" sort="Growdon, J H" uniqKey="Growdon J" first="J. H." last="Growdon">J. H. Growdon</name><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name><name sortKey="Hendricks, A E" sort="Hendricks, A E" uniqKey="Hendricks A" first="A. E." last="Hendricks">A. E. Hendricks</name><name sortKey="Isaacson, S" sort="Isaacson, S" uniqKey="Isaacson S" first="S." last="Isaacson">S. Isaacson</name><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><name sortKey="Laramie, J M" sort="Laramie, J M" uniqKey="Laramie J" first="J. M." last="Laramie">J. M. Laramie</name><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name><name sortKey="Lew, M F" sort="Lew, M F" uniqKey="Lew M" first="M. F." last="Lew">M. F. Lew</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><name sortKey="Massood, T" sort="Massood, T" uniqKey="Massood T" first="T." last="Massood">T. Massood</name><name sortKey="Moller, A T" sort="Moller, A T" uniqKey="Moller A" first="A. T." last="Moller">A. T. Moller</name><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><name sortKey="Nagle, M W" sort="Nagle, M W" uniqKey="Nagle M" first="M. W." last="Nagle">M. W. Nagle</name><name sortKey="Nance, M" sort="Nance, M" uniqKey="Nance M" first="M." last="Nance">M. Nance</name><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name><name sortKey="Ostergaard, K" sort="Ostergaard, K" uniqKey="Ostergaard K" first="K." last="Ostergaard">K. Ostergaard</name><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name><name sortKey="Roxburgh, R" sort="Roxburgh, R" uniqKey="Roxburgh R" first="R." last="Roxburgh">R. Roxburgh</name><name sortKey="Saint Hilaire, M H" sort="Saint Hilaire, M H" uniqKey="Saint Hilaire M" first="M. H." last="Saint-Hilaire">M. H. Saint-Hilaire</name><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name><name sortKey="Shill, H A" sort="Shill, H A" uniqKey="Shill H" first="H. A." last="Shill">H. A. Shill</name><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><name sortKey="Slevin, J T" sort="Slevin, J T" uniqKey="Slevin J" first="J. T." last="Slevin">J. T. Slevin</name><name sortKey="Snow, B" sort="Snow, B" uniqKey="Snow B" first="B." last="Snow">B. Snow</name><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name><name sortKey="Tobin, J E" sort="Tobin, J E" uniqKey="Tobin J" first="J. E." last="Tobin">J. E. Tobin</name><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name><name sortKey="Williamson, S" sort="Williamson, S" uniqKey="Williamson S" first="S." last="Williamson">S. Williamson</name><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
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|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
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|type= RBID
|clé= PMC:2654275
|texte= Haplotypes and gene expression implicate the MAPT region for Parkinson disease
}}
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