Human Nerual Stem Cells for Brain Repair
Identifieur interne : 002183 ( Main/Exploration ); précédent : 002182; suivant : 002184Human Nerual Stem Cells for Brain Repair
Auteurs : Seung U. Kim [Corée du Sud, Canada] ; Hong J. Lee [Corée du Sud] ; In H. Park [Corée du Sud] ; Kon Chu [Corée du Sud] ; Soon T. Lee [Corée du Sud] ; Manho Kim [Corée du Sud] ; Jae K. Roh [Corée du Sud] ; Seung K. Kim [Corée du Sud] ; Kyu C. Wang [Corée du Sud]Source :
- International Journal of Stem Cells [ 2005-3606 ] ; 2008.
Abstract
Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases including Parkinson disease, Huntington disease, amyotrophic lateral sclerosis (ALS), Alzheimer disease, multiple sclerosis (MS), stroke, spinal cord injury and brain cancer. In recent years, neurons and glial cells have successfully been generated from neural stem cells, and extensive efforts by investigators to develop neural stem cell-based transplantation therapies have been carried out. We review here notable experimental and pre-clinical studies we have previously conducted involving human neural stem cell-based cell- and gene-therapies for Parkinson disease, Huntington disease, ALS, stroke and brain cancer.
Url:
PubMed: 24855505
PubMed Central: 4021772
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases including Parkinson disease, Huntington disease, amyotrophic lateral sclerosis (ALS), Alzheimer disease, multiple sclerosis (MS), stroke, spinal cord injury and brain cancer. In recent years, neurons and glial cells have successfully been generated from neural stem cells, and extensive efforts by investigators to develop neural stem cell-based transplantation therapies have been carried out. We review here notable experimental and pre-clinical studies we have previously conducted involving human neural stem cell-based cell- and gene-therapies for Parkinson disease, Huntington disease, ALS, stroke and brain cancer.</p>
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