ParkinsonCanadaV1, Main, Exploration, bibRecord, 001D53

Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

Identifieur interne : 001D53 ( Main/Exploration ); précédent : 001D52; suivant : 001D54

Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

Auteurs : Thomas Force [États-Unis] ; James R. Woodgett [Canada]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2009.

RBID : PMC:2665084

Abstract

Intensive study over the past 30 years has helped define the role of the GSK-3 (glycogen synthase kinase-3) family in a variety of physiological and pathophysiological processes. However, the majority of these studies have relied upon overexpression approaches or nonselective small molecule inhibitors. Herein, we examine recent data derived from studies in gene-targeted embryonic stem cells and knock-out mice in an attempt to define the role these protein kinases play in critical decisions made by stem/progenitor cells and by early lineage-committed cardiomyocytes during development.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665084

DOI: 10.1074/jbc.R800077200
PubMed: 19064989
PubMed Central: 2665084

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Intensive study over the past 30 years has helped define the role of the
 GSK-3 (<underline>g</underline>
lycogen <underline>s</underline>
ynthase <underline>k</underline>
inase-<underline>3</underline>)
 family in a variety of physiological and pathophysiological processes.
 However, the majority of these studies have relied upon overexpression
 approaches or nonselective small molecule inhibitors. Herein, we examine
 recent data derived from studies in gene-targeted embryonic stem cells and
 knock-out mice in an attempt to define the role these protein kinases play in
 critical decisions made by stem/progenitor cells and by early
 lineage-committed cardiomyocytes during development.</p>
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<country name="Canada"><region name="Ontario"><name sortKey="Woodgett, James R" sort="Woodgett, James R" uniqKey="Woodgett J" first="James R." last="Woodgett">James R. Woodgett</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development*

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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	La maladie de Parkinson au Canada (serveur d'exploration)
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