Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease.
Identifieur interne : 001A26 ( Main/Exploration ); précédent : 001A25; suivant : 001A27Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease.
Auteurs : S J Palmer [Canada] ; J. Li ; Z J Wang ; M J MckeownSource :
- Neuroscience [ 1873-7544 ] ; 2010.
English descriptors
- KwdEn :
- Adaptation, Physiological (physiology), Adult, Aged, Basal Ganglia (anatomy & histology), Basal Ganglia (physiopathology), Brain (anatomy & histology), Brain (physiopathology), Brain Mapping, Cerebellum (anatomy & histology), Cerebellum (physiopathology), Disability Evaluation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (anatomy & histology), Motor Cortex (physiopathology), Nerve Net (anatomy & histology), Nerve Net (physiopathology), Neural Pathways (anatomy & histology), Neural Pathways (physiopathology), Neuronal Plasticity (physiology), Parkinson Disease (physiopathology), Signal Processing, Computer-Assisted, Thalamus (anatomy & histology), Thalamus (physiopathology).
- MESH :
- anatomy & histology : Basal Ganglia, Brain, Cerebellum, Motor Cortex, Nerve Net, Neural Pathways, Thalamus.
- physiology : Adaptation, Physiological, Neuronal Plasticity.
- physiopathology : Basal Ganglia, Brain, Cerebellum, Motor Cortex, Nerve Net, Neural Pathways, Parkinson Disease, Thalamus.
- Adult, Aged, Brain Mapping, Disability Evaluation, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Signal Processing, Computer-Assisted.
Abstract
Neuroimaging studies in Parkinson's disease (PD) have previously demonstrated several regions of hypo- and hyper-activation during voluntary movement. How these patterns of amplitude changes at multiple discrete foci relate to changes within functional networks recruited by a given task is unclear. Changes in both amplitude and connectivity have both been individually shown within the striato-thalamo-cortical (STC) loop in PD, as well as other regions, most consistently in the cerebellum and primary motor cortex. We have previously shown overactivation of the cerebellum and motor cortex in PD subjects off medication during a visuo-motor tracking task performed at three frequencies. Here, we show that this change in activation amplitude is also accompanied by significant changes in functional connectivity between regions of interest (ROIs), with enhanced connectivity within the cerebello-thalamo-cortical (CTC) loop as well as increased inter-hemispheric communication between several basal ganglia structures. Although changes in activation amplitude were influenced by the frequency of movement performed in the tracking task, functional connectivity changes were robustly present across all three task frequencies performed, suggesting that functional connectivity analysis in PD may be a more sensitive means of detecting plastic changes which are relatively invariant to the particulars of the experimental task. Additionally, we demonstrate amplitude and connectivity changes in structures that are typically active during the resting state, or "default-mode," in PD. Unlike in STC/CTC loops, where the direction of change was the same for amplitude and connectivity, default-mode regions showed increased amplitude but decreased connectivity. Our results further support that the CTC is recruited in PD to compensate for dysfunctional basal ganglia circuits, and that this recruitment involves both amplitude and connectivity changes. The differing relationship between amplitude and connectivity changes within individual loops highlights the importance of jointly examining them in order to fully elucidate functional changes in Parkinson's disease.
DOI: 10.1016/j.neuroscience.2010.01.012
PubMed: 20074617
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D61
- to stream PubMed, to step Curation: 000D61
- to stream PubMed, to step Checkpoint: 000D61
- to stream Ncbi, to step Merge: 000B99
- to stream Ncbi, to step Curation: 000B99
- to stream Ncbi, to step Checkpoint: 000B99
- to stream Main, to step Merge: 001B33
- to stream Main, to step Curation: 001A26
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease.</title>
<author><name sortKey="Palmer, S J" sort="Palmer, S J" uniqKey="Palmer S" first="S J" last="Palmer">S J Palmer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Neuroscience, University of British Columbia, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J" last="Li">J. Li</name>
</author>
<author><name sortKey="Wang, Z J" sort="Wang, Z J" uniqKey="Wang Z" first="Z J" last="Wang">Z J Wang</name>
</author>
<author><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M J" last="Mckeown">M J Mckeown</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="RBID">pubmed:20074617</idno>
<idno type="pmid">20074617</idno>
<idno type="doi">10.1016/j.neuroscience.2010.01.012</idno>
<idno type="wicri:Area/PubMed/Corpus">000D61</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D61</idno>
<idno type="wicri:Area/PubMed/Curation">000D61</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D61</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D61</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D61</idno>
<idno type="wicri:Area/Ncbi/Merge">000B99</idno>
<idno type="wicri:Area/Ncbi/Curation">000B99</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B99</idno>
<idno type="wicri:Area/Main/Merge">001B33</idno>
<idno type="wicri:Area/Main/Curation">001A26</idno>
<idno type="wicri:Area/Main/Exploration">001A26</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease.</title>
<author><name sortKey="Palmer, S J" sort="Palmer, S J" uniqKey="Palmer S" first="S J" last="Palmer">S J Palmer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neuroscience, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Neuroscience, University of British Columbia, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J" last="Li">J. Li</name>
</author>
<author><name sortKey="Wang, Z J" sort="Wang, Z J" uniqKey="Wang Z" first="Z J" last="Wang">Z J Wang</name>
</author>
<author><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M J" last="Mckeown">M J Mckeown</name>
</author>
</analytic>
<series><title level="j">Neuroscience</title>
<idno type="eISSN">1873-7544</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term>
<term>Adult</term>
<term>Aged</term>
<term>Basal Ganglia (anatomy & histology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Brain (anatomy & histology)</term>
<term>Brain (physiopathology)</term>
<term>Brain Mapping</term>
<term>Cerebellum (anatomy & histology)</term>
<term>Cerebellum (physiopathology)</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Cortex (anatomy & histology)</term>
<term>Motor Cortex (physiopathology)</term>
<term>Nerve Net (anatomy & histology)</term>
<term>Nerve Net (physiopathology)</term>
<term>Neural Pathways (anatomy & histology)</term>
<term>Neural Pathways (physiopathology)</term>
<term>Neuronal Plasticity (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Signal Processing, Computer-Assisted</term>
<term>Thalamus (anatomy & histology)</term>
<term>Thalamus (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain</term>
<term>Cerebellum</term>
<term>Motor Cortex</term>
<term>Nerve Net</term>
<term>Neural Pathways</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Neuronal Plasticity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain</term>
<term>Cerebellum</term>
<term>Motor Cortex</term>
<term>Nerve Net</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brain Mapping</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Signal Processing, Computer-Assisted</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Neuroimaging studies in Parkinson's disease (PD) have previously demonstrated several regions of hypo- and hyper-activation during voluntary movement. How these patterns of amplitude changes at multiple discrete foci relate to changes within functional networks recruited by a given task is unclear. Changes in both amplitude and connectivity have both been individually shown within the striato-thalamo-cortical (STC) loop in PD, as well as other regions, most consistently in the cerebellum and primary motor cortex. We have previously shown overactivation of the cerebellum and motor cortex in PD subjects off medication during a visuo-motor tracking task performed at three frequencies. Here, we show that this change in activation amplitude is also accompanied by significant changes in functional connectivity between regions of interest (ROIs), with enhanced connectivity within the cerebello-thalamo-cortical (CTC) loop as well as increased inter-hemispheric communication between several basal ganglia structures. Although changes in activation amplitude were influenced by the frequency of movement performed in the tracking task, functional connectivity changes were robustly present across all three task frequencies performed, suggesting that functional connectivity analysis in PD may be a more sensitive means of detecting plastic changes which are relatively invariant to the particulars of the experimental task. Additionally, we demonstrate amplitude and connectivity changes in structures that are typically active during the resting state, or "default-mode," in PD. Unlike in STC/CTC loops, where the direction of change was the same for amplitude and connectivity, default-mode regions showed increased amplitude but decreased connectivity. Our results further support that the CTC is recruited in PD to compensate for dysfunctional basal ganglia circuits, and that this recruitment involves both amplitude and connectivity changes. The differing relationship between amplitude and connectivity changes within individual loops highlights the importance of jointly examining them in order to fully elucidate functional changes in Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Li, J" sort="Li, J" uniqKey="Li J" first="J" last="Li">J. Li</name>
<name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M J" last="Mckeown">M J Mckeown</name>
<name sortKey="Wang, Z J" sort="Wang, Z J" uniqKey="Wang Z" first="Z J" last="Wang">Z J Wang</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Palmer, S J" sort="Palmer, S J" uniqKey="Palmer S" first="S J" last="Palmer">S J Palmer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A26 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A26 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:20074617 |texte= Joint amplitude and connectivity compensatory mechanisms in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20074617" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |