Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
Identifieur interne : 001935 ( Main/Exploration ); précédent : 001934; suivant : 001936Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
Auteurs : Shivraj S. Jhala [Canada] ; Alan S. Hazell [Canada]Source :
- Neurochemistry international [ 0197-0186 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Emerging evidence suggests that thiamine deficiency (TD), the cause of Wernicke's encephalopathy, produces alterations in brain function and structural damage that closely model a number of maladies in which neurodegeneration is a characteristic feature, including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, along with alcoholic brain disease, stroke, and traumatic brain injury. Impaired oxidative metabolism in TD due to decreased activity of thiamine-dependent enzymes leads to a multifactorial cascade of events in the brain that include focal decreases in energy status, oxidative stress, lactic acidosis, blood-brain barrier disruption, astrocyte dysfunction, glutamate-mediated excitotoxicity, amyloid deposition, decreased glucose utilization, immediate-early gene induction, and inflammation. This review describes our current understanding of the basis of these abnormal processes in TD, their interrelationships, and why this disorder can be useful for our understanding of how decreased cerebral energy metabolism can give rise to cell death in different neurodegenerative disease states.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000343
- to stream PascalFrancis, to step Curation: 000920
- to stream PascalFrancis, to step Checkpoint: 000252
- to stream Main, to step Merge: 001A27
- to stream Main, to step Curation: 001935
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism</title><author><name sortKey="Jhala, Shivraj S" sort="Jhala, Shivraj S" uniqKey="Jhala S" first="Shivraj S." last="Jhala">Shivraj S. Jhala</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University of Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Hazell, Alan S" sort="Hazell, Alan S" uniqKey="Hazell A" first="Alan S." last="Hazell">Alan S. Hazell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University of Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0141669</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0141669 INIST</idno><idno type="RBID">Pascal:11-0141669</idno><idno type="wicri:Area/PascalFrancis/Corpus">000343</idno><idno type="wicri:Area/PascalFrancis/Curation">000920</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000252</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000252</idno><idno type="wicri:doubleKey">0197-0186:2011:Jhala S:modeling:neurodegenerative:disease</idno><idno type="wicri:Area/Main/Merge">001A27</idno><idno type="wicri:Area/Main/Curation">001935</idno><idno type="wicri:Area/Main/Exploration">001935</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism</title><author><name sortKey="Jhala, Shivraj S" sort="Jhala, Shivraj S" uniqKey="Jhala S" first="Shivraj S." last="Jhala">Shivraj S. Jhala</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University of Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Hazell, Alan S" sort="Hazell, Alan S" uniqKey="Hazell A" first="Alan S." last="Hazell">Alan S. Hazell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University of Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurochemistry international</title><title level="j" type="abbreviated">Neurochem. int.</title><idno type="ISSN">0197-0186</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurochemistry international</title><title level="j" type="abbreviated">Neurochem. int.</title><idno type="ISSN">0197-0186</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Astrocyte</term><term>Degeneration</term><term>Degenerative disease</term><term>Excitotoxicity</term><term>Glutamate</term><term>Inflammation</term><term>Metabolism</term><term>Oxidative stress</term><term>Thiamine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Thiamine</term><term>Métabolisme</term><term>Excitotoxicité</term><term>Glutamate</term><term>Astrocyte</term><term>Dégénérescence</term><term>Inflammation</term><term>Stress oxydatif</term><term>Maladie dégénérative</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Emerging evidence suggests that thiamine deficiency (TD), the cause of Wernicke's encephalopathy, produces alterations in brain function and structural damage that closely model a number of maladies in which neurodegeneration is a characteristic feature, including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, multiple sclerosis, along with alcoholic brain disease, stroke, and traumatic brain injury. Impaired oxidative metabolism in TD due to decreased activity of thiamine-dependent enzymes leads to a multifactorial cascade of events in the brain that include focal decreases in energy status, oxidative stress, lactic acidosis, blood-brain barrier disruption, astrocyte dysfunction, glutamate-mediated excitotoxicity, amyloid deposition, decreased glucose utilization, immediate-early gene induction, and inflammation. This review describes our current understanding of the basis of these abnormal processes in TD, their interrelationships, and why this disorder can be useful for our understanding of how decreased cerebral energy metabolism can give rise to cell death in different neurodegenerative disease states.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Jhala, Shivraj S" sort="Jhala, Shivraj S" uniqKey="Jhala S" first="Shivraj S." last="Jhala">Shivraj S. Jhala</name></noRegion><name sortKey="Hazell, Alan S" sort="Hazell, Alan S" uniqKey="Hazell A" first="Alan S." last="Hazell">Alan S. Hazell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001935 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001935 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:11-0141669
|texte= Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
}}
| This area was generated with Dilib version V0.6.29. |  |