ParkinsonCanadaV1, Main, Exploration, bibRecord, 001908

The effects of paraquat on regional brain neurotransmitter activity, hippocampal BDNF and behavioural function in female mice

Identifieur interne : 001908 ( Main/Exploration ); précédent : 001907; suivant : 001909

The effects of paraquat on regional brain neurotransmitter activity, hippocampal BDNF and behavioural function in female mice

Auteurs : Darcy Litteljohn [Canada] ; Eric Nelson [Canada] ; Cheri Bethune [Canada] ; Shawn Hayley [Canada]

Source :

Neuroscience letters [ 0304-3940 ] ; 2011.

RBID : Pascal:11-0427235

Descripteurs français

Pascal (Inist)
- Paraquat, Encéphale, Neurotransmetteur, Hippocampe, Facteur BDNF, Comportement, Femelle, Monoamine, Maladie de Parkinson, Souris, Animal.

English descriptors

KwdEn :
- Animal, Behavior, Brain derived neurotrophic factor, Encephalon, Female, Hippocampus, Monoamine, Mouse, Neurotransmitter, Paraquat, Parkinson disease.

Abstract

Accumulating evidence implicates pesticides such as paraquat in the development of Parkinson's disease (PD). Indeed, paraquat exposure is associated with an increased risk of PD and when administered to rodents the pesticide recapitulates many of the neuropathological and behavioural features of the disease. However, it is unclear whether any sexual dimorphism exists in the in vivo murine response to paraquat intoxication, since most studies have used exclusively males. Accordingly, we sought to determine the impact of repeated paraquat exposure on a range of neural and behavioural outcomes in female C57BL/6J mice. The present investigation revealed that the female mice were largely resistant to the paraquat-induced nigrostriatal dopamine changes and locomotor deficits that were reported previously in males. Similarly, in contrast to the reductions of hippocamapal brain-derived neurotrophic factor (BDNF) previously reported in paraquat treated male mice, the herbicide actually increased levels of the trophic factor in females. Yet, similar to our previous findings in males, paraquat increased norepinephrine utilization within the hippocampus and prefrontal cortex of the female mice. However, these changes did not translate into anxiety- or- depression-like behaviours in the open field test, as the females actually seemed to show enhanced exploration. Consistent with reports of a greater incidence of PD in males, these data suggest that female mice may be less susceptible than males to the nigrostriatal dopaminergic and motor effects of environmental toxins. The augmented hippocampal BDNF and noradrenergic changes observed could conceivably act to buffer female mice against some of the deleterious behavioural effects of parquat.

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000278
to stream PascalFrancis, to step Curation: 000985
to stream PascalFrancis, to step Checkpoint: 000214
to stream Main, to step Merge: 001989
to stream Main, to step Curation: 001908

Le document en format XML

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<front><div type="abstract" xml:lang="en">Accumulating evidence implicates pesticides such as paraquat in the development of Parkinson's disease (PD). Indeed, paraquat exposure is associated with an increased risk of PD and when administered to rodents the pesticide recapitulates many of the neuropathological and behavioural features of the disease. However, it is unclear whether any sexual dimorphism exists in the in vivo murine response to paraquat intoxication, since most studies have used exclusively males. Accordingly, we sought to determine the impact of repeated paraquat exposure on a range of neural and behavioural outcomes in female C57BL/6J mice. The present investigation revealed that the female mice were largely resistant to the paraquat-induced nigrostriatal dopamine changes and locomotor deficits that were reported previously in males. Similarly, in contrast to the reductions of hippocamapal brain-derived neurotrophic factor (BDNF) previously reported in paraquat treated male mice, the herbicide actually increased levels of the trophic factor in females. Yet, similar to our previous findings in males, paraquat increased norepinephrine utilization within the hippocampus and prefrontal cortex of the female mice. However, these changes did not translate into anxiety- or- depression-like behaviours in the open field test, as the females actually seemed to show enhanced exploration. Consistent with reports of a greater incidence of PD in males, these data suggest that female mice may be less susceptible than males to the nigrostriatal dopaminergic and motor effects of environmental toxins. The augmented hippocampal BDNF and noradrenergic changes observed could conceivably act to buffer female mice against some of the deleterious behavioural effects of parquat.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

The effects of paraquat on regional brain neurotransmitter activity, hippocampal BDNF and behavioural function in female mice

The effects of paraquat on regional brain neurotransmitter activity, hippocampal BDNF and behavioural function in female mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri