Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey
Identifieur interne : 001863 ( Main/Exploration ); précédent : 001862; suivant : 001864Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey
Auteurs : C. Osiowy [Canada] ; B. Larke [Canada] ; E. Giles [Canada]Source :
- Journal of Viral Hepatitis [ 1352-0504 ] ; 2011-04.
English descriptors
- KwdEn :
Abstract
Summary. Very little is known of hepatitis B virus (HBV) in Canadian Arctic indigenous populations, where HBV was considered endemic prior to the introduction of HBV vaccine. This study expands upon an HBV seroepidemiological survey conducted between 1983 and 1985 throughout the Canadian Arctic, to characterize HBV in this population. Archived hepatitis B surface antigen (HBsAg)‐positive sera (n = 401) were processed for HBV DNA, followed by sequencing and phylogenetic analysis of the HBsAg‐ and HBcAg‐coding regions. Sixty‐nine per cent of samples (277/401) were DNA positive, with most having low viral load (median 3.4 log 10 IU/mL). The predominant HBV genotype observed was genotype B (HBV/B, 75%), followed by HBV/D (24%) and HBV/A (1%). All HBV/B strains clustered within subgenotype B6, a newly recognized HBV genotype among western circumpolar Inuit and Alaska Native people. HBV/D strains included both D3 (88%) and D4 (12%) subgenotypes, while all HBV/A strains were subgenotype A2. An association of HBV genotype B with Inuit living in the eastern Arctic and an association of genotype D with First Nation (Dene) living in the western Arctic was observed. This study establishes the high prevalence of HBV/B6 and HBV/D genotypes in Arctic populations and reveals their marked distribution within the Canadian Arctic based on geographical and demographic attributes.
Url:
DOI: 10.1111/j.1365-2893.2010.01356.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001427
- to stream Istex, to step Curation: 001427
- to stream Istex, to step Checkpoint: 000448
- to stream Main, to step Merge: 001941
- to stream Main, to step Curation: 001863
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey</title><author><name sortKey="Osiowy, C" sort="Osiowy, C" uniqKey="Osiowy C" first="C." last="Osiowy">C. Osiowy</name></author><author><name sortKey="Larke, B" sort="Larke, B" uniqKey="Larke B" first="B." last="Larke">B. Larke</name></author><author><name sortKey="Giles, E" sort="Giles, E" uniqKey="Giles E" first="E." last="Giles">E. Giles</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C2586083CAFB86B5E4D29482B7A7C499A850309A</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1365-2893.2010.01356.x</idno><idno type="url">https://api-v5.istex.fr/document/C2586083CAFB86B5E4D29482B7A7C499A850309A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001427</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001427</idno><idno type="wicri:Area/Istex/Curation">001427</idno><idno type="wicri:Area/Istex/Checkpoint">000448</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000448</idno><idno type="wicri:doubleKey">1352-0504:2011:Osiowy C:distinct:geographical:and</idno><idno type="wicri:Area/Main/Merge">001941</idno><idno type="wicri:Area/Main/Curation">001863</idno><idno type="wicri:Area/Main/Exploration">001863</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey</title><author><name sortKey="Osiowy, C" sort="Osiowy, C" uniqKey="Osiowy C" first="C." last="Osiowy">C. Osiowy</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Bloodborne Pathogens and Hepatitis, National Microbiology Laboratory, Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author><author><name sortKey="Larke, B" sort="Larke, B" uniqKey="Larke B" first="B." last="Larke">B. Larke</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Health and Social Services, Yukon Territorial Government, Whitehorse, YT</wicri:regionArea><wicri:noRegion>YT</wicri:noRegion></affiliation></author><author><name sortKey="Giles, E" sort="Giles, E" uniqKey="Giles E" first="E." last="Giles">E. Giles</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Bloodborne Pathogens and Hepatitis, National Microbiology Laboratory, Winnipeg, MB</wicri:regionArea><wicri:noRegion>MB</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Viral Hepatitis</title><idno type="ISSN">1352-0504</idno><idno type="eISSN">1365-2893</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-04">2011-04</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="11">e11</biblScope><biblScope unit="page" to="19">e19</biblScope></imprint><idno type="ISSN">1352-0504</idno></series><idno type="istex">C2586083CAFB86B5E4D29482B7A7C499A850309A</idno><idno type="DOI">10.1111/j.1365-2893.2010.01356.x</idno><idno type="ArticleID">JVH1356</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1352-0504</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Inuit</term><term>arctic</term><term>genotype</term><term>hepatitis B virus</term><term>mutant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary. Very little is known of hepatitis B virus (HBV) in Canadian Arctic indigenous populations, where HBV was considered endemic prior to the introduction of HBV vaccine. This study expands upon an HBV seroepidemiological survey conducted between 1983 and 1985 throughout the Canadian Arctic, to characterize HBV in this population. Archived hepatitis B surface antigen (HBsAg)‐positive sera (n = 401) were processed for HBV DNA, followed by sequencing and phylogenetic analysis of the HBsAg‐ and HBcAg‐coding regions. Sixty‐nine per cent of samples (277/401) were DNA positive, with most having low viral load (median 3.4 log 10 IU/mL). The predominant HBV genotype observed was genotype B (HBV/B, 75%), followed by HBV/D (24%) and HBV/A (1%). All HBV/B strains clustered within subgenotype B6, a newly recognized HBV genotype among western circumpolar Inuit and Alaska Native people. HBV/D strains included both D3 (88%) and D4 (12%) subgenotypes, while all HBV/A strains were subgenotype A2. An association of HBV genotype B with Inuit living in the eastern Arctic and an association of genotype D with First Nation (Dene) living in the western Arctic was observed. This study establishes the high prevalence of HBV/B6 and HBV/D genotypes in Arctic populations and reveals their marked distribution within the Canadian Arctic based on geographical and demographic attributes.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Osiowy, C" sort="Osiowy, C" uniqKey="Osiowy C" first="C." last="Osiowy">C. Osiowy</name></noRegion><name sortKey="Giles, E" sort="Giles, E" uniqKey="Giles E" first="E." last="Giles">E. Giles</name><name sortKey="Larke, B" sort="Larke, B" uniqKey="Larke B" first="B." last="Larke">B. Larke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001863 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001863 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:C2586083CAFB86B5E4D29482B7A7C499A850309A
|texte= Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey
}}
| This area was generated with Dilib version V0.6.29. |  |