Free‐Energy Landscapes of Ion Movement through a G‐Quadruplex DNA Channel
Identifieur interne : 001430 ( Main/Exploration ); précédent : 001429; suivant : 001431Free‐Energy Landscapes of Ion Movement through a G‐Quadruplex DNA Channel
Auteurs : Parisa Akhshi [Canada] ; Parisa Mosey [Canada] ; Parisa Wu [Canada]Source :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2012-03-19.
English descriptors
Abstract
How easily can ions move in DNA channels? Three‐dimensional free‐energy landscapes for the movement of Na+, K+, and NH4+ ions through G‐quadruplex DNA channels have been obtained by molecular dynamics simulations. The computed results are in qualitative agreement with the limited experimental data: large K+ and NH4+ ions squeeze through the G‐quartets with some difficulty, while Na+ ions pass through with less impedance.
Url:
DOI: 10.1002/anie.201107700
Affiliations:
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<front><div type="abstract">How easily can ions move in DNA channels? Three‐dimensional free‐energy landscapes for the movement of Na+, K+, and NH4+ ions through G‐quadruplex DNA channels have been obtained by molecular dynamics simulations. The computed results are in qualitative agreement with the limited experimental data: large K+ and NH4+ ions squeeze through the G‐quartets with some difficulty, while Na+ ions pass through with less impedance.</div>
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<name sortKey="Wu, Parisa" sort="Wu, Parisa" uniqKey="Wu P" first="Parisa" last="Wu">Parisa Wu</name>
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