Nanomaterials for Ocular Drug Delivery
Identifieur interne : 001392 ( Main/Exploration ); précédent : 001391; suivant : 001393Nanomaterials for Ocular Drug Delivery
Auteurs : Shengyan Liu [Canada] ; Lyndon Jones [Canada] ; Frank X. Gu [Canada]Source :
- Macromolecular Bioscience [ 1616-5187 ] ; 2012-05.
English descriptors
Abstract
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial‐based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.
Url:
DOI: 10.1002/mabi.201100419
Affiliations:
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Gu</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1</wicri:regionArea><wicri:noRegion>N2L 3G1</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1</wicri:regionArea><wicri:noRegion>N2L 3G1</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Macromolecular Bioscience</title><title level="j" type="abbrev">Macromol. Biosci.</title><idno type="ISSN">1616-5187</idno><idno type="eISSN">1616-5195</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2012-05">2012-05</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="608">608</biblScope><biblScope unit="page" to="620">620</biblScope></imprint><idno type="ISSN">1616-5187</idno></series><idno type="istex">42525C3D035E7545F7B7AD28064D05BBE15DFE1D</idno><idno type="DOI">10.1002/mabi.201100419</idno><idno type="ArticleID">MABI201100419</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1616-5187</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>contact lenses</term><term>drug delivery systems</term><term>nanomaterials</term><term>nanotechnology</term><term>ocular drug delivery</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial‐based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Liu, Shengyan" sort="Liu, Shengyan" uniqKey="Liu S" first="Shengyan" last="Liu">Shengyan Liu</name></noRegion><name sortKey="Gu, Frank X" sort="Gu, Frank X" uniqKey="Gu F" first="Frank X." last="Gu">Frank X. Gu</name><name sortKey="Gu, Frank X" sort="Gu, Frank X" uniqKey="Gu F" first="Frank X." last="Gu">Frank X. Gu</name><name sortKey="Jones, Lyndon" sort="Jones, Lyndon" uniqKey="Jones L" first="Lyndon" last="Jones">Lyndon Jones</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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