ParkinsonCanadaV1, Main, Exploration, bibRecord, 001040

The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease

Identifieur interne : 001040 ( Main/Exploration ); précédent : 001039; suivant : 001041

The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease

Auteurs : Hong-Lei Li [République populaire de Chine] ; Shen-Ji Lu [République populaire de Chine] ; Yi-Min Sun [République populaire de Chine] ; Qi-Hao Guo [République populaire de Chine] ; Adele Dessa Sadovnick [Canada] ; Zhi-Ying Wu [République populaire de Chine]

Source :

CNS neuroscience & therapeutics : (Print) [ 1755-5930 ] ; 2013.

RBID : Pascal:13-0164500

Descripteurs français

Pascal (Inist)
- Démence d'Alzheimer, Prévention, Chinois.

English descriptors

KwdEn :
- Alzheimer disease, Chinese, Prevention.

Abstract

Aims: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders that may share some overlapping etiologies. Mutations within leucine-rich repeat kinase 2 (LRRK2) have been reported to be responsible for PD, and the location of LRRK2 is within a linkage peak for sporadic AD (SAD). The aim of this study was to investigate two Asian-specific LRRK2 variants, R1628P and G2385R, with the association of Han Chinese SAD. Methods: Genotyping of R1628P and G2385R was performed by PCR-restriction fragment length polymorphism (RFLP) analysis in 390 patients with SAD and 545 unrelated age- and sex-matched healthy controls. Results: The frequency of the C allele within R1628P was more than three times higher in control group (1.7%) than in patients with SAD (0.5%) (OR 0.264; 95% CI, 0.088-0.792, P = 0.018). After stratification by the presence of one or two apolipoprotein E ε4 alleles, the protective effect becomes stronger (ε44: OR 0.028; 95% CI, 0.003-0.303, P = 0.003; ε4: OR 0.104; 95% CI, 0.013- 0.818, P = 0.031). However, no difference was found in G2385R variant. Conclusion: Our study suggested that R1628P variant within LRRK2 plays a protective role in Han Chinese population with SAD and such effect has an interaction with the APOE genotype.

Affiliations:

Canada, République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000103
to stream PascalFrancis, to step Curation: 000B29
to stream PascalFrancis, to step Checkpoint: 000046
to stream Main, to step Merge: 001053
to stream Main, to step Curation: 001040

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease</title>
<author><name sortKey="Li, Hong Lei" sort="Li, Hong Lei" uniqKey="Li H" first="Hong-Lei" last="Li">Hong-Lei Li</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Shen Ji" sort="Lu, Shen Ji" uniqKey="Lu S" first="Shen-Ji" last="Lu">Shen-Ji Lu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sun, Yi Min" sort="Sun, Yi Min" uniqKey="Sun Y" first="Yi-Min" last="Sun">Yi-Min Sun</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Qi Hao" sort="Guo, Qi Hao" uniqKey="Guo Q" first="Qi-Hao" last="Guo">Qi-Hao Guo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sadovnick, Adele Dessa" sort="Sadovnick, Adele Dessa" uniqKey="Sadovnick A" first="Adele Dessa" last="Sadovnick">Adele Dessa Sadovnick</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Genetics and Division of Neurology, Faculty of Medicine, University of British Columbia</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver, BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Zhi Ying" sort="Wu, Zhi Ying" uniqKey="Wu Z" first="Zhi-Ying" last="Wu">Zhi-Ying Wu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0164500</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0164500 INIST</idno>
<idno type="RBID">Pascal:13-0164500</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000103</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B29</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000046</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000046</idno>
<idno type="wicri:doubleKey">1755-5930:2013:Li H:the:lrrk:r</idno>
<idno type="wicri:Area/Main/Merge">001053</idno>
<idno type="wicri:Area/Main/Curation">001040</idno>
<idno type="wicri:Area/Main/Exploration">001040</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease</title>
<author><name sortKey="Li, Hong Lei" sort="Li, Hong Lei" uniqKey="Li H" first="Hong-Lei" last="Li">Hong-Lei Li</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Shen Ji" sort="Lu, Shen Ji" uniqKey="Lu S" first="Shen-Ji" last="Lu">Shen-Ji Lu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sun, Yi Min" sort="Sun, Yi Min" uniqKey="Sun Y" first="Yi-Min" last="Sun">Yi-Min Sun</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Qi Hao" sort="Guo, Qi Hao" uniqKey="Guo Q" first="Qi-Hao" last="Guo">Qi-Hao Guo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sadovnick, Adele Dessa" sort="Sadovnick, Adele Dessa" uniqKey="Sadovnick A" first="Adele Dessa" last="Sadovnick">Adele Dessa Sadovnick</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Genetics and Division of Neurology, Faculty of Medicine, University of British Columbia</s1>
<s2>Vancouver, BC</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver, BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Zhi Ying" sort="Wu, Zhi Ying" uniqKey="Wu Z" first="Zhi-Ying" last="Wu">Zhi-Ying Wu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">CNS neuroscience & therapeutics : (Print)</title>
<title level="j" type="abbreviated">CNS neurosci. ther. : (Print)</title>
<idno type="ISSN">1755-5930</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">CNS neuroscience & therapeutics : (Print)</title>
<title level="j" type="abbreviated">CNS neurosci. ther. : (Print)</title>
<idno type="ISSN">1755-5930</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term>
<term>Chinese</term>
<term>Prevention</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Démence d'Alzheimer</term>
<term>Prévention</term>
<term>Chinois</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aims: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders that may share some overlapping etiologies. Mutations within leucine-rich repeat kinase 2 (LRRK2) have been reported to be responsible for PD, and the location of LRRK2 is within a linkage peak for sporadic AD (SAD). The aim of this study was to investigate two Asian-specific LRRK2 variants, R1628P and G2385R, with the association of Han Chinese SAD. Methods: Genotyping of R1628P and G2385R was performed by PCR-restriction fragment length polymorphism (RFLP) analysis in 390 patients with SAD and 545 unrelated age- and sex-matched healthy controls. Results: The frequency of the C allele within R1628P was more than three times higher in control group (1.7%) than in patients with SAD (0.5%) (OR 0.264; 95% CI, 0.088-0.792, P = 0.018). After stratification by the presence of one or two apolipoprotein E ε4 alleles, the protective effect becomes stronger (ε44: OR 0.028; 95% CI, 0.003-0.303, P = 0.003; ε4: OR 0.104; 95% CI, 0.013- 0.818, P = 0.031). However, no difference was found in G2385R variant. Conclusion: Our study suggested that R1628P variant within LRRK2 plays a protective role in Han Chinese population with SAD and such effect has an interaction with the APOE genotype.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Hong Lei" sort="Li, Hong Lei" uniqKey="Li H" first="Hong-Lei" last="Li">Hong-Lei Li</name>
</noRegion>
<name sortKey="Guo, Qi Hao" sort="Guo, Qi Hao" uniqKey="Guo Q" first="Qi-Hao" last="Guo">Qi-Hao Guo</name>
<name sortKey="Lu, Shen Ji" sort="Lu, Shen Ji" uniqKey="Lu S" first="Shen-Ji" last="Lu">Shen-Ji Lu</name>
<name sortKey="Sun, Yi Min" sort="Sun, Yi Min" uniqKey="Sun Y" first="Yi-Min" last="Sun">Yi-Min Sun</name>
<name sortKey="Wu, Zhi Ying" sort="Wu, Zhi Ying" uniqKey="Wu Z" first="Zhi-Ying" last="Wu">Zhi-Ying Wu</name>
</country>
<country name="Canada"><noRegion><name sortKey="Sadovnick, Adele Dessa" sort="Sadovnick, Adele Dessa" uniqKey="Sadovnick A" first="Adele Dessa" last="Sadovnick">Adele Dessa Sadovnick</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001040 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001040 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0164500
   |texte=   The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease

The LRRK2 R1628P Variant Plays a Protective Role in Han Chinese Population with Alzheimer's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri