ParkinsonCanadaV1, Main, Exploration, bibRecord, 000E74

A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600*

Identifieur interne : 000E74 ( Main/Exploration ); précédent : 000E73; suivant : 000E75

A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600*

Auteurs : Camille Belzil ; Gernot Neumayer ; Alex P. Vassilev [États-Unis] ; Kyoko L. Yap ; Hiroaki Konishi ; Serge Rivest ; Kamon Sanada ; Mitsuhiko Ikura ; Yoshihiro Nakatani ; Minh Dang Nguyen

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3750145

Abstract

Background: The microtubule-associated protein p600 forms a complex with the Ca²⁺ sensor calmodulin.

Results: Knockdown of p600 or specific disruption of the Ca²⁺-dependent calmodulin/p600 binding triggers neuronal death following Ca²⁺ elevation.

Conclusion: p600 is required for survival of hippocampal neurons following glutamate-induced Ca²⁺ elevation.

Significance: This novel role for p600 in Ca²⁺ signaling and neuronal death has broad relevance to the study of neurodegeneration.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750145

DOI: 10.1074/jbc.M113.483107
PubMed: 23861403
PubMed Central: 3750145

Affiliations:

Le document en format XML

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<author><name sortKey="Belzil, Camille" sort="Belzil, Camille" uniqKey="Belzil C" first="Camille" last="Belzil">Camille Belzil</name>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The microtubule-associated protein p600 forms a complex with the Ca<sup>2+</sup>
 sensor calmodulin.</p>
<p><bold>Results:</bold>
 Knockdown of p600 or specific disruption of the Ca<sup>2+</sup>
-dependent calmodulin/p600 binding triggers neuronal death following Ca<sup>2+</sup>
 elevation.</p>
<p><bold>Conclusion:</bold>
 p600 is required for survival of hippocampal neurons following glutamate-induced Ca<sup>2+</sup>
 elevation.</p>
<p><bold>Significance:</bold>
 This novel role for p600 in Ca<sup>2+</sup>
 signaling and neuronal death has broad relevance to the study of neurodegeneration.</p>
</div>
</front>
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<name sortKey="Ikura, Mitsuhiko" sort="Ikura, Mitsuhiko" uniqKey="Ikura M" first="Mitsuhiko" last="Ikura">Mitsuhiko Ikura</name>
<name sortKey="Konishi, Hiroaki" sort="Konishi, Hiroaki" uniqKey="Konishi H" first="Hiroaki" last="Konishi">Hiroaki Konishi</name>
<name sortKey="Nakatani, Yoshihiro" sort="Nakatani, Yoshihiro" uniqKey="Nakatani Y" first="Yoshihiro" last="Nakatani">Yoshihiro Nakatani</name>
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<name sortKey="Nguyen, Minh Dang" sort="Nguyen, Minh Dang" uniqKey="Nguyen M" first="Minh Dang" last="Nguyen">Minh Dang Nguyen</name>
<name sortKey="Rivest, Serge" sort="Rivest, Serge" uniqKey="Rivest S" first="Serge" last="Rivest">Serge Rivest</name>
<name sortKey="Sanada, Kamon" sort="Sanada, Kamon" uniqKey="Sanada K" first="Kamon" last="Sanada">Kamon Sanada</name>
<name sortKey="Yap, Kyoko L" sort="Yap, Kyoko L" uniqKey="Yap K" first="Kyoko L." last="Yap">Kyoko L. Yap</name>
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<country name="États-Unis"><region name="Maryland"><name sortKey="Vassilev, Alex P" sort="Vassilev, Alex P" uniqKey="Vassilev A" first="Alex P." last="Vassilev">Alex P. Vassilev</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600*

A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600*

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Abstract

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