ParkinsonCanadaV1, Main, Exploration, bibRecord, 000C15

Adult hemiparkinsonian rats do not benefit from tactile stimulation

Identifieur interne : 000C15 ( Main/Exploration ); précédent : 000C14; suivant : 000C16

Adult hemiparkinsonian rats do not benefit from tactile stimulation

Auteurs : Anna Effenberg [Allemagne] ; Alexander Klein [Allemagne] ; Robbin Gibb [Canada] ; Cathy Carroll [Canada] ; Wolfgang Baumgartner [Allemagne] ; Claudia Grothea [Allemagne] ; Andreas Ratzka [Allemagne]

Source :

Behavioural brain research [ 0166-4328 ] ; 2014.

RBID : Pascal:14-0086803

Descripteurs français

Pascal (Inist)
- Animal adulte, Sensibilité tactile, Corps strié, Neurone dopaminergique, Maladie de Parkinson, Rat.

English descriptors

KwdEn :
- Adult animal, Corpus striatum, Dopaminergic neuron, Parkinson disease, Rat, Tactile sensitivity.

Abstract

Tactile stimulation (TS) applied to adult rats after cortical injury (medial frontal cortex aspiration or sensorimotor pial stripping stroke model) has been previously shown to ameliorate behavioral impairments and to improve morphological parameters like dendritic length of prefrontal cortical neurons (Gibb et al., 2010). The purpose of this study was to examine the effect of TS on healthy and hemiparkinsonian adult rats. Therefore, the animals received TS for 14 days and 15 min three times daily. At different time points rats were tested in various behavioral tests (amphetamine-induced rotation, cylinder test, staircase test). Finally, rats were sacrificed, their brains removed, and processed for Golgi-Cox analyses, tyrosine hydroxylase immunohistochemistry and quantitative RT-PCR. We found that the striatal 6-OHDA lesion itself induced a long-term increase of astroglial Fgf2 transcript levels, but was not further increased by TS. In contrast TS applied to healthy rats elicited a transient short-term increase of Fgf2 in the striatum and Bdnf, Grin 1, and Fgf2 in the hippocampus. Moreover, behavioral and histological analyses do not support a beneficial effect of TS for hemiparkinsonian rats, applied for two weeks starting one day after partial striatal 6-OHDA lesion.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000032
to stream PascalFrancis, to step Corpus: 000053
to stream PascalFrancis, to step Curation: 000B86
to stream PascalFrancis, to step Checkpoint: 000035
to stream Main, to step Merge: 000C20
to stream Main, to step Curation: 000C15

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Adult hemiparkinsonian rats do not benefit from tactile stimulation</title>
<author><name sortKey="Effenberg, Anna" sort="Effenberg, Anna" uniqKey="Effenberg A" first="Anna" last="Effenberg">Anna Effenberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibb, Robbin" sort="Gibb, Robbin" uniqKey="Gibb R" first="Robbin" last="Gibb">Robbin Gibb</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Canadian Centre for Behavioral Neuroscience, The University of Lethbridge</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carroll, Cathy" sort="Carroll, Cathy" uniqKey="Carroll C" first="Cathy" last="Carroll">Cathy Carroll</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Canadian Centre for Behavioral Neuroscience, The University of Lethbridge</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baumgartner, Wolfgang" sort="Baumgartner, Wolfgang" uniqKey="Baumgartner W" first="Wolfgang" last="Baumgartner">Wolfgang Baumgartner</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Systems Neuroscience (ZSN), Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Pathology, University of Veterinary Medicine</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grothea, Claudia" sort="Grothea, Claudia" uniqKey="Grothea C" first="Claudia" last="Grothea">Claudia Grothea</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Systems Neuroscience (ZSN), Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ratzka, Andreas" sort="Ratzka, Andreas" uniqKey="Ratzka A" first="Andreas" last="Ratzka">Andreas Ratzka</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0086803</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0086803 INIST</idno>
<idno type="RBID">Pascal:14-0086803</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000032</idno>
<idno type="stanalyst">FRANCIS 14-0086803 INIST</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000053</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B86</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000035</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000035</idno>
<idno type="wicri:doubleKey">0166-4328:2014:Effenberg A:adult:hemiparkinsonian:rats</idno>
<idno type="wicri:Area/Main/Merge">000C20</idno>
<idno type="wicri:Area/Main/Curation">000C15</idno>
<idno type="wicri:Area/Main/Exploration">000C15</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Adult hemiparkinsonian rats do not benefit from tactile stimulation</title>
<author><name sortKey="Effenberg, Anna" sort="Effenberg, Anna" uniqKey="Effenberg A" first="Anna" last="Effenberg">Anna Effenberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibb, Robbin" sort="Gibb, Robbin" uniqKey="Gibb R" first="Robbin" last="Gibb">Robbin Gibb</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Canadian Centre for Behavioral Neuroscience, The University of Lethbridge</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carroll, Cathy" sort="Carroll, Cathy" uniqKey="Carroll C" first="Cathy" last="Carroll">Cathy Carroll</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Canadian Centre for Behavioral Neuroscience, The University of Lethbridge</s1>
<s2>Alberta</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Alberta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baumgartner, Wolfgang" sort="Baumgartner, Wolfgang" uniqKey="Baumgartner W" first="Wolfgang" last="Baumgartner">Wolfgang Baumgartner</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Systems Neuroscience (ZSN), Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Pathology, University of Veterinary Medicine</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grothea, Claudia" sort="Grothea, Claudia" uniqKey="Grothea C" first="Claudia" last="Grothea">Claudia Grothea</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre for Systems Neuroscience (ZSN), Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ratzka, Andreas" sort="Ratzka, Andreas" uniqKey="Ratzka A" first="Andreas" last="Ratzka">Andreas Ratzka</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Neuroanatomy, Hannover Medical School</s1>
<s2>Hannover</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Behavioural brain research</title>
<title level="j" type="abbreviated">Behav. brain res.</title>
<idno type="ISSN">0166-4328</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Behavioural brain research</title>
<title level="j" type="abbreviated">Behav. brain res.</title>
<idno type="ISSN">0166-4328</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult animal</term>
<term>Corpus striatum</term>
<term>Dopaminergic neuron</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Tactile sensitivity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal adulte</term>
<term>Sensibilité tactile</term>
<term>Corps strié</term>
<term>Neurone dopaminergique</term>
<term>Maladie de Parkinson</term>
<term>Rat</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Tactile stimulation (TS) applied to adult rats after cortical injury (medial frontal cortex aspiration or sensorimotor pial stripping stroke model) has been previously shown to ameliorate behavioral impairments and to improve morphological parameters like dendritic length of prefrontal cortical neurons (Gibb et al., 2010). The purpose of this study was to examine the effect of TS on healthy and hemiparkinsonian adult rats. Therefore, the animals received TS for 14 days and 15 min three times daily. At different time points rats were tested in various behavioral tests (amphetamine-induced rotation, cylinder test, staircase test). Finally, rats were sacrificed, their brains removed, and processed for Golgi-Cox analyses, tyrosine hydroxylase immunohistochemistry and quantitative RT-PCR. We found that the striatal 6-OHDA lesion itself induced a long-term increase of astroglial Fgf2 transcript levels, but was not further increased by TS. In contrast TS applied to healthy rats elicited a transient short-term increase of Fgf2 in the striatum and Bdnf, Grin 1, and Fgf2 in the hippocampus. Moreover, behavioral and histological analyses do not support a beneficial effect of TS for hemiparkinsonian rats, applied for two weeks starting one day after partial striatal 6-OHDA lesion.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
</country>
<region><li>Basse-Saxe</li>
</region>
<settlement><li>Hanovre</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Effenberg, Anna" sort="Effenberg, Anna" uniqKey="Effenberg A" first="Anna" last="Effenberg">Anna Effenberg</name>
</region>
<name sortKey="Baumgartner, Wolfgang" sort="Baumgartner, Wolfgang" uniqKey="Baumgartner W" first="Wolfgang" last="Baumgartner">Wolfgang Baumgartner</name>
<name sortKey="Baumgartner, Wolfgang" sort="Baumgartner, Wolfgang" uniqKey="Baumgartner W" first="Wolfgang" last="Baumgartner">Wolfgang Baumgartner</name>
<name sortKey="Grothea, Claudia" sort="Grothea, Claudia" uniqKey="Grothea C" first="Claudia" last="Grothea">Claudia Grothea</name>
<name sortKey="Klein, Alexander" sort="Klein, Alexander" uniqKey="Klein A" first="Alexander" last="Klein">Alexander Klein</name>
<name sortKey="Ratzka, Andreas" sort="Ratzka, Andreas" uniqKey="Ratzka A" first="Andreas" last="Ratzka">Andreas Ratzka</name>
</country>
<country name="Canada"><noRegion><name sortKey="Gibb, Robbin" sort="Gibb, Robbin" uniqKey="Gibb R" first="Robbin" last="Gibb">Robbin Gibb</name>
</noRegion>
<name sortKey="Carroll, Cathy" sort="Carroll, Cathy" uniqKey="Carroll C" first="Cathy" last="Carroll">Cathy Carroll</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C15 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C15 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:14-0086803
   |texte=   Adult hemiparkinsonian rats do not benefit from tactile stimulation
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Adult hemiparkinsonian rats do not benefit from tactile stimulation

Adult hemiparkinsonian rats do not benefit from tactile stimulation

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri