Deep Brain Stimulation for Disorders of Memory and Cognition
Identifieur interne : 000B05 ( Main/Exploration ); précédent : 000B04; suivant : 000B06Deep Brain Stimulation for Disorders of Memory and Cognition
Auteurs : Tejas Sankar ; Nir Lipsman ; Andres M. LozanoSource :
- Neurotherapeutics [ 1933-7213 ] ; 2014.
Abstract
The next several decades will see an exponential rise in the number of patients with disorders of memory and cognition, and of Alzheimer’s disease in particular. Impending demographic shifts, an absence of effective treatments, and the significant burden these conditions place on patients, caregivers, and society, mean there is an urgent need to develop novel therapies. Deep brain stimulation (DBS) is a neurosurgical procedure that is a standard-of-care for many patients with treatment-refractory Parkinson’s disease, dystonia, and essential tremor. DBS has proven to be an effective means of modulating activity in disrupted motor circuitry, and has shown promise as a modulator of other dysfunctional circuits, including for mood and anxiety disorders. The deficits in Alzheimer’s disease and other disorders of memory and cognition are also beginning to be thought of as arising from dysfunction in neural circuits. Such dysfunction may be amenable to modulation using focal brain stimulation. A global experience is now emerging for the use of DBS for these conditions, targeting key nodes in the memory circuit, including the fornix and nucleus basalis of Meynert. Such work holds promise as a novel therapeutic approach for one of medicine’s most urgent priorities.
The online version of this article (doi:10.1007/s13311-014-0275-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s13311-014-0275-0
PubMed: 24777384
PubMed Central: 4121440
Affiliations:
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Lozano</name><affiliation><nlm:aff id="Aff2">Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St. WW 4-447, Toronto, Ontario M5T 2S8 Canada</nlm:aff><wicri:noCountry code="subfield">Ontario M5T 2S8 Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Neurotherapeutics</title><idno type="ISSN">1933-7213</idno><idno type="eISSN">1878-7479</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The next several decades will see an exponential rise in the number of patients with disorders of memory and cognition, and of Alzheimer’s disease in particular. Impending demographic shifts, an absence of effective treatments, and the significant burden these conditions place on patients, caregivers, and society, mean there is an urgent need to develop novel therapies. Deep brain stimulation (DBS) is a neurosurgical procedure that is a standard-of-care for many patients with treatment-refractory Parkinson’s disease, dystonia, and essential tremor. DBS has proven to be an effective means of modulating activity in disrupted motor circuitry, and has shown promise as a modulator of other dysfunctional circuits, including for mood and anxiety disorders. The deficits in Alzheimer’s disease and other disorders of memory and cognition are also beginning to be thought of as arising from dysfunction in neural circuits. Such dysfunction may be amenable to modulation using focal brain stimulation. A global experience is now emerging for the use of DBS for these conditions, targeting key nodes in the memory circuit, including the fornix and nucleus basalis of Meynert. Such work holds promise as a novel therapeutic approach for one of medicine’s most urgent priorities.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s13311-014-0275-0) contains supplementary material, which is available to authorized users.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lipsman, Nir" sort="Lipsman, Nir" uniqKey="Lipsman N" first="Nir" last="Lipsman">Nir Lipsman</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Sankar, Tejas" sort="Sankar, Tejas" uniqKey="Sankar T" first="Tejas" last="Sankar">Tejas Sankar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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