No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial
Identifieur interne : 000991 ( Main/Exploration ); précédent : 000990; suivant : 000992No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial
Auteurs : Chizoba C. Umeh [États-Unis] ; Adriana Pérez [États-Unis] ; Erika F. Augustine [États-Unis] ; Rohit Dhall [États-Unis] ; Richard B. Dewey [États-Unis] ; Zoltan Mari [États-Unis] ; David K. Simon [États-Unis] ; Anne-Marie A. Wills [États-Unis] ; Chadwick W. Christine [États-Unis] ; Jay S. Schneider [États-Unis] ; Oksana Suchowersky [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- Wicri :
- geographic : Canada, États-Unis.
English descriptors
- KwdEn :
- Aged, Canada, Dopamine Agents (administration & dosage), Dopamine Agents (therapeutic use), Female, Humans, Levodopa (administration & dosage), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Severity of Illness Index, Sex Factors, Treatment Outcome, United States.
- MESH :
- chemical , administration & dosage : Dopamine Agents, Levodopa.
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- geographic : Canada, United States.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Sex Factors, Treatment Outcome.
Abstract
Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease. The objective of this study was to test if there are differences in the type of dopaminergic medication used and levodopa equivalent daily dose between men and women with early Parkinson disease enrolled in a large multicenter study of Creatine as a potential disease modifying therapy – the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease Long-Term Study-1.
Baseline data of 1,741 participants from 45 participating sites were analyzed. Participants from the United States and Canada were enrolled within five years of Parkinson Disease diagnosis. Two outcome variables were studied: type of dopaminergic medication used and levodopa equivalent daily dose at baseline in the Long-Term Study-1. Chi-square statistic and linear regression models were used for statistical analysis.
There were no statistically significant differences in the frequency of use of different types of dopaminergic medications at baseline between men and women with Parkinson Disease. A small but statistically significant difference was observed in the median unadjusted levodopa equivalent daily dose at baseline between women (300 mg) and men (325 mg), but this was not observed after controlling for disease duration (years since Parkinson disease diagnosis), disease severity (Unified Parkinson's Disease Rating Scale Motor and Activities of Daily Living Scores), and body weight.
In this large multicenter study, we did not observe sex differences in the type and dose of dopaminergic medications used in early Parkinson Disease. Further research is needed to evaluate the influence of male or female sex on use of dopaminergic medication in mid- and late-stage Parkinson Disease.
Url:
DOI: 10.1371/journal.pone.0112287
PubMed: 25486269
PubMed Central: 4259292
Affiliations:
- Canada, États-Unis
- Arizona, Californie, Maryland, Massachusetts, Pennsylvanie, Texas, État de New York
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Schneider</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Departments of Medicine (Neurology), Medical Genetics and Pediatrics, University of Alberta, Edmonton, Alberta, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Medicine (Neurology), Medical Genetics and Pediatrics, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25486269</idno><idno type="pmc">4259292</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259292</idno><idno type="RBID">PMC:4259292</idno><idno type="doi">10.1371/journal.pone.0112287</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000093</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000093</idno><idno type="wicri:Area/Pmc/Curation">000093</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000093</idno><idno type="wicri:Area/Pmc/Checkpoint">000438</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000438</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000623</idno><idno type="wicri:Area/PubMed/Curation">000623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000623</idno><idno type="wicri:Area/PubMed/Checkpoint">000623</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000623</idno><idno type="wicri:Area/Ncbi/Merge">001994</idno><idno type="wicri:Area/Ncbi/Curation">001994</idno><idno type="wicri:Area/Ncbi/Checkpoint">001994</idno><idno type="wicri:Area/Main/Merge">000993</idno><idno type="wicri:Area/Main/Curation">000991</idno><idno type="wicri:Area/Main/Exploration">000991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial</title><author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C." last="Umeh">Chizoba C. Umeh</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology and Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Biostatistics, The University of Texas School of Public Health, Austin, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, The University of Texas School of Public Health, Austin, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Augustine, Erika F" sort="Augustine, Erika F" uniqKey="Augustine E" first="Erika F." last="Augustine">Erika F. Augustine</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Neurology, University of Rochester Medical Center, Rochester, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dhall, Rohit" sort="Dhall, Rohit" uniqKey="Dhall R" first="Rohit" last="Dhall">Rohit Dhall</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B." last="Dewey">Richard B. Dewey</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K." last="Simon">David K. 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Wills</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W." last="Christine">Chadwick W. Christine</name><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Neurology, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S." last="Schneider">Jay S. Schneider</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Departments of Medicine (Neurology), Medical Genetics and Pediatrics, University of Alberta, Edmonton, Alberta, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Medicine (Neurology), Medical Genetics and Pediatrics, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Canada</term><term>Dopamine Agents (administration & dosage)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Severity of Illness Index</term><term>Sex Factors</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Canada</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Sex Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease. The objective of this study was to test if there are differences in the type of dopaminergic medication used and levodopa equivalent daily dose between men and women with early Parkinson disease enrolled in a large multicenter study of Creatine as a potential disease modifying therapy – the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease Long-Term Study-1.</p></sec><sec><title>Methods</title><p>Baseline data of 1,741 participants from 45 participating sites were analyzed. Participants from the United States and Canada were enrolled within five years of Parkinson Disease diagnosis. Two outcome variables were studied: type of dopaminergic medication used and levodopa equivalent daily dose at baseline in the Long-Term Study-1. Chi-square statistic and linear regression models were used for statistical analysis.</p></sec><sec><title>Results</title><p>There were no statistically significant differences in the frequency of use of different types of dopaminergic medications at baseline between men and women with Parkinson Disease. A small but statistically significant difference was observed in the median unadjusted levodopa equivalent daily dose at baseline between women (300 mg) and men (325 mg), but this was not observed after controlling for disease duration (years since Parkinson disease diagnosis), disease severity (Unified Parkinson's Disease Rating Scale Motor and Activities of Daily Living Scores), and body weight.</p></sec><sec><title>Conclusions</title><p>In this large multicenter study, we did not observe sex differences in the type and dose of dopaminergic medications used in early Parkinson Disease. Further research is needed to evaluate the influence of male or female sex on use of dopaminergic medication in mid- and late-stage Parkinson Disease.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hoffmann, De" uniqKey="Hoffmann D">DE Hoffmann</name></author><author><name sortKey="Tarzian, Aj" uniqKey="Tarzian A">AJ Tarzian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blomkalns, Al" uniqKey="Blomkalns A">AL Blomkalns</name></author><author><name sortKey="Chen, Ay" uniqKey="Chen A">AY Chen</name></author><author><name sortKey="Hochman, Js" uniqKey="Hochman J">JS Hochman</name></author><author><name sortKey="Peterson, Ed" uniqKey="Peterson E">ED Peterson</name></author><author><name sortKey="Trynosky, K" uniqKey="Trynosky K">K Trynosky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reeves, Mj" uniqKey="Reeves M">MJ Reeves</name></author><author><name 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Elm</name></author><author><name sortKey="The, Nnetpdi" uniqKey="The N">NNETPDI The</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomlinson, Cl" uniqKey="Tomlinson C">CL Tomlinson</name></author><author><name sortKey="Stowe, R" uniqKey="Stowe R">R Stowe</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Rick, C" uniqKey="Rick C">C Rick</name></author><author><name sortKey="Gray, R" uniqKey="Gray R">R Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Box, Gep" uniqKey="Box G">GEP Box</name></author><author><name sortKey="Cox, Dr" uniqKey="Cox D">DR Cox</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, Lm" uniqKey="Shulman L">LM Shulman</name></author><author><name sortKey="Bhat, V" uniqKey="Bhat V">V Bhat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zappia, M" uniqKey="Zappia M">M Zappia</name></author><author><name sortKey="Crescibene, L" uniqKey="Crescibene L">L Crescibene</name></author><author><name sortKey="Arabia, G" uniqKey="Arabia G">G Arabia</name></author><author><name sortKey="Nicoletti, G" uniqKey="Nicoletti G">G Nicoletti</name></author><author><name sortKey="Bagala, A" uniqKey="Bagala A">A Bagala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warren Olanow, C" uniqKey="Warren Olanow C">C Warren Olanow</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Saunders Pullman, R" uniqKey="Saunders Pullman R">R Saunders-Pullman</name></author><author><name sortKey="Gordon Elliott, J" uniqKey="Gordon Elliott J">J Gordon-Elliott</name></author><author><name sortKey="Parides, M" uniqKey="Parides M">M Parides</name></author><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author><author><name sortKey="Saunders, Hr" uniqKey="Saunders H">HR Saunders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, Kl" uniqKey="Tsang K">KL Tsang</name></author><author><name sortKey="Ho, Sl" uniqKey="Ho S">SL Ho</name></author><author><name sortKey="Lo, Sk" uniqKey="Lo S">SK Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Session, Dr" uniqKey="Session D">DR Session</name></author><author><name sortKey="Pearlstone, Mm" uniqKey="Pearlstone M">MM Pearlstone</name></author><author><name sortKey="Jewelewicz, R" uniqKey="Jewelewicz R">R Jewelewicz</name></author><author><name sortKey="Kelly, Ac" uniqKey="Kelly A">AC Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willis, Aw" uniqKey="Willis A">AW Willis</name></author><author><name sortKey="Schootman, M" uniqKey="Schootman M">M Schootman</name></author><author><name sortKey="Kung, N" uniqKey="Kung N">N Kung</name></author><author><name sortKey="Wang, Xy" uniqKey="Wang X">XY Wang</name></author><author><name sortKey="Perlmutter, Js" uniqKey="Perlmutter J">JS Perlmutter</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Arizona</li><li>Californie</li><li>Maryland</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Texas</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C." last="Umeh">Chizoba C. Umeh</name></region><name sortKey="Augustine, Erika F" sort="Augustine, Erika F" uniqKey="Augustine E" first="Erika F." last="Augustine">Erika F. Augustine</name><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W." last="Christine">Chadwick W. Christine</name><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B." last="Dewey">Richard B. Dewey</name><name sortKey="Dhall, Rohit" sort="Dhall, Rohit" uniqKey="Dhall R" first="Rohit" last="Dhall">Rohit Dhall</name><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S." last="Schneider">Jay S. Schneider</name><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K." last="Simon">David K. Simon</name><name sortKey="Wills, Anne Marie A" sort="Wills, Anne Marie A" uniqKey="Wills A" first="Anne-Marie A." last="Wills">Anne-Marie A. Wills</name></country><country name="Canada"><noRegion><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial
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