Efficacy of the porcine species in biomedical research
Identifieur interne : 000743 ( Main/Exploration ); précédent : 000742; suivant : 000744Efficacy of the porcine species in biomedical research
Auteurs : Karina Gutierrez [Canada] ; Naomi Dicks [Canada] ; Werner G. Glanzner [Canada] ; Luis B. Agellon [Canada] ; Vilceu Bordignon [Canada]Source :
- Frontiers in Genetics [ 1664-8021 ] ; 2015.
Abstract
Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they have been used in biomedical research, given they share many physiological and anatomical similarities with humans. Recent technological advances in assisted reproduction, somatic cell cloning, stem cell culture, genome editing, and transgenesis now enable the creation of unique porcine models of human diseases. Here, we highlight the potential applications and advantages of using pigs, particularly minipigs, as indispensable large animal models in fundamental and clinical research, including the development of therapeutics for inherited and chronic disorders, and cancers.
Url:
DOI: 10.3389/fgene.2015.00293
PubMed: 26442109
PubMed Central: 4584988
Affiliations:
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Glanzner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Animal Science, McGill University, Sainte-Anne-de-Bellevue</institution><country>QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Agellon, Luis B" sort="Agellon, Luis B" uniqKey="Agellon L" first="Luis B." last="Agellon">Luis B. Agellon</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>School of Dietetics and Human Nutrition, McGill University, Sainte-Anne-de-Bellevue</institution><country>QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Bordignon, Vilceu" sort="Bordignon, Vilceu" uniqKey="Bordignon V" first="Vilceu" last="Bordignon">Vilceu Bordignon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Animal Science, McGill University, Sainte-Anne-de-Bellevue</institution><country>QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Genetics</title><idno type="eISSN">1664-8021</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since domestication, pigs have been used extensively in agriculture and kept as companion animals. More recently they have been used in biomedical research, given they share many physiological and anatomical similarities with humans. Recent technological advances in assisted reproduction, somatic cell cloning, stem cell culture, genome editing, and transgenesis now enable the creation of unique porcine models of human diseases. Here, we highlight the potential applications and advantages of using pigs, particularly minipigs, as indispensable large animal models in fundamental and clinical research, including the development of therapeutics for inherited and chronic disorders, and cancers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abukawa, H" uniqKey="Abukawa H">H. Abukawa</name></author><author><name sortKey="Terai, H" uniqKey="Terai H">H. Terai</name></author><author><name sortKey="Hannouche, D" uniqKey="Hannouche D">D. Hannouche</name></author><author><name sortKey="Vacanti, J P" uniqKey="Vacanti J">J. P. 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Hao</name></author><author><name sortKey="Spate, L D" uniqKey="Spate L">L. D. Spate</name></author><author><name sortKey="Walters, E M" uniqKey="Walters E">E. M. Walters</name></author><author><name sortKey="Samuel, M S" uniqKey="Samuel M">M. S. Samuel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Gutierrez, Karina" sort="Gutierrez, Karina" uniqKey="Gutierrez K" first="Karina" last="Gutierrez">Karina Gutierrez</name></noRegion><name sortKey="Agellon, Luis B" sort="Agellon, Luis B" uniqKey="Agellon L" first="Luis B." last="Agellon">Luis B. Agellon</name><name sortKey="Bordignon, Vilceu" sort="Bordignon, Vilceu" uniqKey="Bordignon V" first="Vilceu" last="Bordignon">Vilceu Bordignon</name><name sortKey="Dicks, Naomi" sort="Dicks, Naomi" uniqKey="Dicks N" first="Naomi" last="Dicks">Naomi Dicks</name><name sortKey="Glanzner, Werner G" sort="Glanzner, Werner G" uniqKey="Glanzner W" first="Werner G." last="Glanzner">Werner G. Glanzner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000743 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000743 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4584988
|texte= Efficacy of the porcine species in biomedical research
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26442109" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |