Genome-wide variant by serum urate interaction in Parkinson's disease.
Identifieur interne : 000712 ( Main/Exploration ); précédent : 000711; suivant : 000713Genome-wide variant by serum urate interaction in Parkinson's disease.
Auteurs : Arash Nazeri [Canada] ; Tina Roostaei [Canada] ; Shokufeh Sadaghiani [Canada] ; M Mallar Chakravarty [Canada] ; Shirley Eberly [États-Unis] ; Anthony E. Lang [Canada] ; Aristotle N. Voineskos [Canada]Source :
- Annals of neurology [ 1531-8249 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Behavior, Corpus Striatum (diagnostic imaging), Corpus Striatum (metabolism), Disease Progression, Dopamine (deficiency), Dopamine (genetics), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Inositol Polyphosphate 5-Phosphatases, Magnetic Resonance Imaging, Male, Middle Aged, Nortropanes, Parkinson Disease (blood), Parkinson Disease (diagnostic imaging), Parkinson Disease (genetics), Phosphoric Monoester Hydrolases (genetics), Phosphoric Monoester Hydrolases (metabolism), Predictive Value of Tests, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon, Uric Acid (blood).
- MESH :
- chemical , blood : Uric Acid.
- chemical , deficiency : Dopamine.
- blood : Parkinson Disease.
- diagnostic imaging : Corpus Striatum, Parkinson Disease.
- chemical , genetics : Dopamine, Dopamine Plasma Membrane Transport Proteins, Parkinson Disease, Phosphoric Monoester Hydrolases.
- metabolism : Corpus Striatum, Dopamine Plasma Membrane Transport Proteins, Phosphoric Monoester Hydrolases.
- Adult, Aged, Aged, 80 and over, Behavior, Disease Progression, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Inositol Polyphosphate 5-Phosphatases, Magnetic Resonance Imaging, Male, Middle Aged, Nortropanes, Predictive Value of Tests, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon.
Abstract
Serum urate levels have been associated with risk for and progression of Parkinson's disease (PD). Urate-related compounds are therapeutic candidates in neuroprotective efforts to slow PD progression. A urate-elevating agent is currently under investigation as a potential disease-modifying strategy in people with PD. However, PD is a heterogeneous disorder, and genetic variation may explain divergence in disease severity and progression.
DOI: 10.1002/ana.24504
PubMed: 26284320
Affiliations:
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Le document en format XML
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<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
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<front><div type="abstract" xml:lang="en">Serum urate levels have been associated with risk for and progression of Parkinson's disease (PD). Urate-related compounds are therapeutic candidates in neuroprotective efforts to slow PD progression. A urate-elevating agent is currently under investigation as a potential disease-modifying strategy in people with PD. However, PD is a heterogeneous disorder, and genetic variation may explain divergence in disease severity and progression.</div>
</front>
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<name sortKey="Chakravarty, M Mallar" sort="Chakravarty, M Mallar" uniqKey="Chakravarty M" first="M Mallar" last="Chakravarty">M Mallar Chakravarty</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
<name sortKey="Roostaei, Tina" sort="Roostaei, Tina" uniqKey="Roostaei T" first="Tina" last="Roostaei">Tina Roostaei</name>
<name sortKey="Sadaghiani, Shokufeh" sort="Sadaghiani, Shokufeh" uniqKey="Sadaghiani S" first="Shokufeh" last="Sadaghiani">Shokufeh Sadaghiani</name>
<name sortKey="Voineskos, Aristotle N" sort="Voineskos, Aristotle N" uniqKey="Voineskos A" first="Aristotle N" last="Voineskos">Aristotle N. Voineskos</name>
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<country name="États-Unis"><region name="État de New York"><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
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