Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs
Identifieur interne : 000705 ( Main/Exploration ); précédent : 000704; suivant : 000706Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs
Auteurs : Laura E. Mcbreairty ; Jason L. Robinson ; Kayla R. Furlong ; Janet A. Brunton ; Robert F. BertoloSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Creatine (Cr) is an important high-energy phosphate buffer in tissues with a high energy demand such as muscle and brain and is consequently a highly consumed nutritional supplement. Creatine is synthesized via the S-adenosylmethionine (SAM) dependent methylation of guanidinoacetate (GAA) which is not regulated by a feedback mechanism. The first objective of this study was to determine the effectiveness of GAA at increasing tissue Cr stores. Because SAM is required for other methylation reactions, we also wanted to determine whether an increased creatine synthesis would lead to a lower availability of methyl groups for other methylated products. Three month-old pigs (
Url:
DOI: 10.1371/journal.pone.0131563
PubMed: 26110793
PubMed Central: 4482513
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000076
- to stream Pmc, to step Curation: 000076
- to stream Pmc, to step Checkpoint: 000295
- to stream Ncbi, to step Merge: 001C17
- to stream Ncbi, to step Curation: 001C17
- to stream Ncbi, to step Checkpoint: 001C17
- to stream Main, to step Merge: 000706
- to stream Main, to step Curation: 000705
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs</title><author><name sortKey="Mcbreairty, Laura E" sort="Mcbreairty, Laura E" uniqKey="Mcbreairty L" first="Laura E." last="Mcbreairty">Laura E. Mcbreairty</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Robinson, Jason L" sort="Robinson, Jason L" uniqKey="Robinson J" first="Jason L." last="Robinson">Jason L. Robinson</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Furlong, Kayla R" sort="Furlong, Kayla R" uniqKey="Furlong K" first="Kayla R." last="Furlong">Kayla R. Furlong</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Brunton, Janet A" sort="Brunton, Janet A" uniqKey="Brunton J" first="Janet A." last="Brunton">Janet A. Brunton</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Bertolo, Robert F" sort="Bertolo, Robert F" uniqKey="Bertolo R" first="Robert F." last="Bertolo">Robert F. Bertolo</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26110793</idno><idno type="pmc">4482513</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482513</idno><idno type="RBID">PMC:4482513</idno><idno type="doi">10.1371/journal.pone.0131563</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000076</idno><idno type="wicri:Area/Pmc/Curation">000076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000076</idno><idno type="wicri:Area/Pmc/Checkpoint">000295</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000295</idno><idno type="wicri:Area/Ncbi/Merge">001C17</idno><idno type="wicri:Area/Ncbi/Curation">001C17</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C17</idno><idno type="wicri:Area/Main/Merge">000706</idno><idno type="wicri:Area/Main/Curation">000705</idno><idno type="wicri:Area/Main/Exploration">000705</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs</title><author><name sortKey="Mcbreairty, Laura E" sort="Mcbreairty, Laura E" uniqKey="Mcbreairty L" first="Laura E." last="Mcbreairty">Laura E. Mcbreairty</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Robinson, Jason L" sort="Robinson, Jason L" uniqKey="Robinson J" first="Jason L." last="Robinson">Jason L. Robinson</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Furlong, Kayla R" sort="Furlong, Kayla R" uniqKey="Furlong K" first="Kayla R." last="Furlong">Kayla R. Furlong</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Brunton, Janet A" sort="Brunton, Janet A" uniqKey="Brunton J" first="Janet A." last="Brunton">Janet A. Brunton</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Bertolo, Robert F" sort="Bertolo, Robert F" uniqKey="Bertolo R" first="Robert F." last="Bertolo">Robert F. Bertolo</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Creatine (Cr) is an important high-energy phosphate buffer in tissues with a high energy demand such as muscle and brain and is consequently a highly consumed nutritional supplement. Creatine is synthesized via the S-adenosylmethionine (SAM) dependent methylation of guanidinoacetate (GAA) which is not regulated by a feedback mechanism. The first objective of this study was to determine the effectiveness of GAA at increasing tissue Cr stores. Because SAM is required for other methylation reactions, we also wanted to determine whether an increased creatine synthesis would lead to a lower availability of methyl groups for other methylated products. Three month-old pigs (<italic>n</italic> = 18) were fed control, GAA- or Cr-supplemented diets twice daily. On day 18 or 19, anesthesia was induced 1–3 hours post feeding and a bolus of [methyl-<sup>3</sup>H]methionine was intravenously infused. After 30 minutes, the liver was analyzed for methyl-<sup>3</sup>H incorporation into protein, Cr, phosphatidylcholine (PC) and DNA. Although both Cr and GAA led to higher hepatic Cr concentration, only supplementation with GAA led to higher levels of muscle Cr (<italic>P</italic> < 0.05). Only GAA supplementation resulted in lower methyl-<sup>3</sup>H incorporation into PC and protein as well as lower hepatic SAM concentration compared to the controls, suggesting that Cr synthesis resulted in a limited methyl supply for PC and protein synthesis (<italic>P</italic> < 0.05). Although GAA is more effective than Cr at supporting muscle Cr accretion, further research should be conducted into the long term consequences of a limited methyl supply and its effects on protein and PC homeostasis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Stead, Lm" uniqKey="Stead L">LM Stead</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Vance, De" uniqKey="Vance D">DE Vance</name></author><author><name sortKey="Jacobs, Rl" uniqKey="Jacobs R">RL Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wyss, M" uniqKey="Wyss M">M Wyss</name></author><author><name sortKey="Kaddurah Daouk, R" uniqKey="Kaddurah Daouk R">R Kaddurah-Daouk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Jb" uniqKey="Walker J">JB Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ueland, Pm" uniqKey="Ueland P">PM Ueland</name></author><author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name></author><author><name sortKey="Beresford, Sa" uniqKey="Beresford S">SA Beresford</name></author><author><name sortKey="Vollset, Se" uniqKey="Vollset S">SE Vollset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bemben, Mg" uniqKey="Bemben M">MG Bemben</name></author><author><name sortKey="Lamont, Hs" uniqKey="Lamont H">HS Lamont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barber, Jj" uniqKey="Barber J">JJ Barber</name></author><author><name sortKey="Mcdermott, Ay" uniqKey="Mcdermott A">AY McDermott</name></author><author><name sortKey="Mcgaughey, Kj" uniqKey="Mcgaughey K">KJ McGaughey</name></author><author><name sortKey="Olmstead, Jd" uniqKey="Olmstead J">JD Olmstead</name></author><author><name sortKey="Hagobian, Ta" uniqKey="Hagobian T">TA Hagobian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dabidi Roshan, V" uniqKey="Dabidi Roshan V">V Dabidi Roshan</name></author><author><name sortKey="Babaei, H" uniqKey="Babaei H">H Babaei</name></author><author><name sortKey="Hosseinzadeh, M" uniqKey="Hosseinzadeh M">M Hosseinzadeh</name></author><author><name sortKey="Arendt Nielsen, L" uniqKey="Arendt Nielsen L">L Arendt-Nielsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pe A Altamira, E" uniqKey="Pe A Altamira E">E Peña-Altamira</name></author><author><name sortKey="Crochemore, C" uniqKey="Crochemore C">C Crochemore</name></author><author><name sortKey="Virgili, M" uniqKey="Virgili M">M Virgili</name></author><author><name sortKey="Contestabile, A" uniqKey="Contestabile A">A Contestabile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bender, A" uniqKey="Bender A">A Bender</name></author><author><name sortKey="Samtleben, W" uniqKey="Samtleben W">W Samtleben</name></author><author><name sortKey="Elstner, M" uniqKey="Elstner M">M Elstner</name></author><author><name sortKey="Klopstock, T" uniqKey="Klopstock T">T Klopstock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hersch, Sm" uniqKey="Hersch S">SM Hersch</name></author><author><name sortKey="Gevorkian, S" uniqKey="Gevorkian S">S Gevorkian</name></author><author><name sortKey="Marder, K" uniqKey="Marder K">K Marder</name></author><author><name sortKey="Moskowitz, C" uniqKey="Moskowitz C">C Moskowitz</name></author><author><name sortKey="Feigin, A" uniqKey="Feigin A">A Feigin</name></author><author><name sortKey="Cox, M" uniqKey="Cox M">M Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Austic, Re" uniqKey="Austic R">RE Austic</name></author><author><name sortKey="Nesheim, Mc" uniqKey="Nesheim M">MC Nesheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chamruspollert, M" uniqKey="Chamruspollert M">M Chamruspollert</name></author><author><name sortKey="Pesti, Gm" uniqKey="Pesti G">GM Pesti</name></author><author><name sortKey="Bakalli, Ri" uniqKey="Bakalli R">RI Bakalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baker, Dh" uniqKey="Baker D">DH Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dilger, Rn" uniqKey="Dilger R">RN Dilger</name></author><author><name sortKey="Bryant Angeloni, K" uniqKey="Bryant Angeloni K">K Bryant-Angeloni</name></author><author><name sortKey="Payne, Rl" uniqKey="Payne R">RL Payne</name></author><author><name sortKey="Lemme, A" uniqKey="Lemme A">A Lemme</name></author><author><name sortKey="Parsons, Cm" uniqKey="Parsons C">CM Parsons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michiels, J" uniqKey="Michiels J">J Michiels</name></author><author><name sortKey="Maertens, L" uniqKey="Maertens L">L Maertens</name></author><author><name sortKey="Buyse, J" uniqKey="Buyse J">J Buyse</name></author><author><name sortKey="Lemme, A" uniqKey="Lemme A">A Lemme</name></author><author><name sortKey="Rademacher, M" uniqKey="Rademacher M">M Rademacher</name></author><author><name sortKey="Dierick, Na" uniqKey="Dierick N">NA Dierick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostojic, Sm" uniqKey="Ostojic S">SM Ostojic</name></author><author><name sortKey="Stojanovic, M" uniqKey="Stojanovic M">M Stojanovic</name></author><author><name sortKey="Drid, P" uniqKey="Drid P">P Drid</name></author><author><name sortKey="Hoffman, Jr" uniqKey="Hoffman J">JR Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stead, Lm" uniqKey="Stead L">LM Stead</name></author><author><name sortKey="Au, Kp" uniqKey="Au K">KP Au</name></author><author><name sortKey="Jacobs, Rl" uniqKey="Jacobs R">RL Jacobs</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcbreairty, Le" uniqKey="Mcbreairty L">LE McBreairty</name></author><author><name sortKey="Mcgowan, Ra" uniqKey="Mcgowan R">RA McGowan</name></author><author><name sortKey="Brunton, Ja" uniqKey="Brunton J">JA Brunton</name></author><author><name sortKey="Bertolo, Rf" uniqKey="Bertolo R">RF Bertolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcguire, Dm" uniqKey="Mcguire D">DM McGuire</name></author><author><name sortKey="Gross, Md" uniqKey="Gross M">MD Gross</name></author><author><name sortKey="Van Pilsum, Jf" uniqKey="Van Pilsum J">JF van Pilsum</name></author><author><name sortKey="Towle, Hc" uniqKey="Towle H">HC Towle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deminice, R" uniqKey="Deminice R">R Deminice</name></author><author><name sortKey="Portari, Gv" uniqKey="Portari G">GV Portari</name></author><author><name sortKey="Vannucchi, H" uniqKey="Vannucchi H">H Vannucchi</name></author><author><name sortKey="Jordao, Aa" uniqKey="Jordao A">AA Jordao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, A" uniqKey="Gordon A">A Gordon</name></author><author><name sortKey="Hultman, E" uniqKey="Hultman E">E Hultman</name></author><author><name sortKey="Kaijser, L" uniqKey="Kaijser L">L Kaijser</name></author><author><name sortKey="Kristjansson, S" uniqKey="Kristjansson S">S Kristjansson</name></author><author><name sortKey="Rolf, Cj" uniqKey="Rolf C">CJ Rolf</name></author><author><name sortKey="Nyquist, O" uniqKey="Nyquist O">O Nyquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Rc" uniqKey="Harris R">RC Harris</name></author><author><name sortKey="Soderlund, K" uniqKey="Soderlund K">K Söderlund</name></author><author><name sortKey="Hultman, E" uniqKey="Hultman E">E Hultman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gazzaneo, Mc" uniqKey="Gazzaneo M">MC Gazzaneo</name></author><author><name sortKey="Orellana, Ra" uniqKey="Orellana R">RA Orellana</name></author><author><name sortKey="Suryawan, A" uniqKey="Suryawan A">A Suryawan</name></author><author><name sortKey="Tuckow, Ap" uniqKey="Tuckow A">AP Tuckow</name></author><author><name sortKey="Kimball, Sr" uniqKey="Kimball S">SR Kimball</name></author><author><name sortKey="Wilson, Fa" uniqKey="Wilson F">FA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vester, B" uniqKey="Vester B">B Vester</name></author><author><name sortKey="Rasmussen, K" uniqKey="Rasmussen K">K Rasmussen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchberger, W" uniqKey="Buchberger W">W Buchberger</name></author><author><name sortKey="Ferdig, M" uniqKey="Ferdig M">M Ferdig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratnam, S" uniqKey="Ratnam S">S Ratnam</name></author><author><name sortKey="Wijekoon, Ep" uniqKey="Wijekoon E">EP Wijekoon</name></author><author><name sortKey="Hall, B" uniqKey="Hall B">B Hall</name></author><author><name sortKey="Garrow, Ta" uniqKey="Garrow T">TA Garrow</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bidlingmeyer, Ba" uniqKey="Bidlingmeyer B">BA Bidlingmeyer</name></author><author><name sortKey="Cohen, Sa" uniqKey="Cohen S">SA Cohen</name></author><author><name sortKey="Tarvin, Tl" uniqKey="Tarvin T">TL Tarvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamarre, Sg" uniqKey="Lamarre S">SG Lamarre</name></author><author><name sortKey="Edison, Ee" uniqKey="Edison E">EE Edison</name></author><author><name sortKey="Wijekoon, Ep" uniqKey="Wijekoon E">EP Wijekoon</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Folch, J" uniqKey="Folch J">J Folch</name></author><author><name sortKey="Lees, M" uniqKey="Lees M">M Lees</name></author><author><name sortKey="Sloane, Stanley Gh" uniqKey="Sloane S">Stanley GH Sloane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartlett, Gr" uniqKey="Bartlett G">GR Bartlett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenhaff, Pl" uniqKey="Greenhaff P">PL Greenhaff</name></author><author><name sortKey="Bodin, K" uniqKey="Bodin K">K Bodin</name></author><author><name sortKey="Soderlund, K" uniqKey="Soderlund K">K Soderlund</name></author><author><name sortKey="Hultman, E" uniqKey="Hultman E">E Hultman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horn, M" uniqKey="Horn M">M Horn</name></author><author><name sortKey="Frantz, S" uniqKey="Frantz S">S Frantz</name></author><author><name sortKey="Remkes, H" uniqKey="Remkes H">H Remkes</name></author><author><name sortKey="Laser, A" uniqKey="Laser A">A Laser</name></author><author><name sortKey="Urban, B" uniqKey="Urban B">B Urban</name></author><author><name sortKey="Mettenleiter, A" uniqKey="Mettenleiter A">A Mettenleiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Syrotuik, Dg" uniqKey="Syrotuik D">DG Syrotuik</name></author><author><name sortKey="Bell, Gj" uniqKey="Bell G">GJ Bell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mora, L" uniqKey="Mora L">L Mora</name></author><author><name sortKey="Sentandreu, Ma" uniqKey="Sentandreu M">MÁ Sentandreu</name></author><author><name sortKey="Toldra, F" uniqKey="Toldra F">F Toldrá</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brault, Jj" uniqKey="Brault J">JJ Brault</name></author><author><name sortKey="Terjung, Rl" uniqKey="Terjung R">RL Terjung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Green, Al" uniqKey="Green A">AL Green</name></author><author><name sortKey="Hultman, E" uniqKey="Hultman E">E Hultman</name></author><author><name sortKey="Macdonald, Ia" uniqKey="Macdonald I">IA Macdonald</name></author><author><name sortKey="Sewell, Da" uniqKey="Sewell D">DA Sewell</name></author><author><name sortKey="Greenhaff, Pl" uniqKey="Greenhaff P">PL Greenhaff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steenge, G" uniqKey="Steenge G">G Steenge</name></author><author><name sortKey="Verhoef, P" uniqKey="Verhoef P">P Verhoef</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loike, Jd" uniqKey="Loike J">JD Loike</name></author><author><name sortKey="Zalutsky, Dl" uniqKey="Zalutsky D">DL Zalutsky</name></author><author><name sortKey="Kaback, E" uniqKey="Kaback E">E Kaback</name></author><author><name sortKey="Mir, Af" uniqKey="Mir A">AF Mir</name></author><author><name sortKey="Miranda, Af" uniqKey="Miranda A">AF Miranda</name></author><author><name sortKey="Silverstein, Sc" uniqKey="Silverstein S">SC Silverstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tachikawa, M" uniqKey="Tachikawa M">M Tachikawa</name></author><author><name sortKey="Ikeda, S" uniqKey="Ikeda S">S Ikeda</name></author><author><name sortKey="Fujinawa, J" uniqKey="Fujinawa J">J Fujinawa</name></author><author><name sortKey="Hirose, S" uniqKey="Hirose S">S Hirose</name></author><author><name sortKey="Akanuma, S" uniqKey="Akanuma S">S Akanuma</name></author><author><name sortKey="Hosoya, K" uniqKey="Hosoya K">K Hosoya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author><author><name sortKey="Wijekoon, Ep" uniqKey="Wijekoon E">EP Wijekoon</name></author><author><name sortKey="Warford Woolgar, L" uniqKey="Warford Woolgar L">L Warford-Woolgar</name></author><author><name sortKey="Trottier, Nl" uniqKey="Trottier N">NL Trottier</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Bertolo, Rf" uniqKey="Bertolo R">RF Bertolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Da Silva, Rp" uniqKey="Da Silva R">RP da Silva</name></author><author><name sortKey="Nissim, I" uniqKey="Nissim I">I Nissim</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edison, Ee" uniqKey="Edison E">EE Edison</name></author><author><name sortKey="Brosnan, Me" uniqKey="Brosnan M">ME Brosnan</name></author><author><name sortKey="Meyer, C" uniqKey="Meyer C">C Meyer</name></author><author><name sortKey="Brosnan, Jt" uniqKey="Brosnan J">JT Brosnan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Rc" uniqKey="Harris R">RC Harris</name></author><author><name sortKey="Lowe, Ja" uniqKey="Lowe J">JA Lowe</name></author><author><name sortKey="Warnes, K" uniqKey="Warnes K">K Warnes</name></author><author><name sortKey="Orme, Ce" uniqKey="Orme C">CE Orme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffman, Dr" uniqKey="Hoffman D">DR Hoffman</name></author><author><name sortKey="Cornatzer, We" uniqKey="Cornatzer W">WE Cornatzer</name></author><author><name sortKey="Duerre, Ja" uniqKey="Duerre J">JA Duerre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostojic, Sm" uniqKey="Ostojic S">SM Ostojic</name></author><author><name sortKey="Niess, B" uniqKey="Niess B">B Niess</name></author><author><name sortKey="Stojanovic, M" uniqKey="Stojanovic M">M Stojanovic</name></author><author><name sortKey="Obrenovic, M" uniqKey="Obrenovic M">M Obrenovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Vance, De" uniqKey="Vance D">DE Vance</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noga, Aa" uniqKey="Noga A">AA Noga</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Vance, De" uniqKey="Vance D">DE Vance</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bertolo, Robert F" sort="Bertolo, Robert F" uniqKey="Bertolo R" first="Robert F." last="Bertolo">Robert F. Bertolo</name><name sortKey="Brunton, Janet A" sort="Brunton, Janet A" uniqKey="Brunton J" first="Janet A." last="Brunton">Janet A. Brunton</name><name sortKey="Furlong, Kayla R" sort="Furlong, Kayla R" uniqKey="Furlong K" first="Kayla R." last="Furlong">Kayla R. Furlong</name><name sortKey="Mcbreairty, Laura E" sort="Mcbreairty, Laura E" uniqKey="Mcbreairty L" first="Laura E." last="Mcbreairty">Laura E. Mcbreairty</name><name sortKey="Robinson, Jason L" sort="Robinson, Jason L" uniqKey="Robinson J" first="Jason L." last="Robinson">Jason L. Robinson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000705 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000705 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4482513
|texte= Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26110793" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |