Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease
Identifieur interne : 000655 ( Main/Exploration ); précédent : 000654; suivant : 000656Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease
Auteurs : Kyle Farmer ; Catherine A. Smith ; Shawn Hayley ; Jeffrey SmithSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Lysophosphatidylcholines, Phosphatidylcholines.
- metabolism : Parkinson Disease, Substantia Nigra.
- Animals, Disease Models, Animal, Humans, Lipid Metabolism, Male, Rats, Tandem Mass Spectrometry.
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting the nigrostriatal pathway, where patients do not manifest motor symptoms until >50% of neurons are lost. Thus, it is of great importance to determine early neuronal changes that may contribute to disease progression. Recent attention has focused on lipids and their role in pro- and anti-apoptotic processes. However, information regarding the lipid alterations in animal models of PD is lacking. In this study, we utilized high performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) and novel HPLC solvent methodology to profile phosphatidylcholines and sphingolipids within the substantia nigra. The ipsilateral substantia nigra pars compacta was collected from rats 21 days after an infusion of 6-hydroxydopamine (6-OHDA), or vehicle into the anterior dorsal striatum. We identified 115 lipid species from their mass/charge ratio using the LMAPS Lipid MS Predict Database. Of these, 19 lipid species (from phosphatidylcholine and lysophosphotidylcholine lipid classes) were significantly altered by 6-OHDA, with most being down-regulated. The two lipid species that were up-regulated were LPC (16:0) and LPC (18:1), which are important for neuroinflammatory signalling. These findings provide a first step in the characterization of lipid changes in early stages of PD-like pathology and could provide novel targets for early interventions in PD.
Url:
DOI: 10.3390/ijms160818865
PubMed: 26274953
PubMed Central: 4581276
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000064
- to stream Pmc, to step Curation: 000064
- to stream Pmc, to step Checkpoint: 000268
- to stream PubMed, to step Corpus: 000441
- to stream PubMed, to step Curation: 000441
- to stream PubMed, to step Checkpoint: 000441
- to stream Ncbi, to step Merge: 001C78
- to stream Ncbi, to step Curation: 001C78
- to stream Ncbi, to step Checkpoint: 001C78
- to stream Main, to step Merge: 000656
- to stream Main, to step Curation: 000655
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease</title><author><name sortKey="Farmer, Kyle" sort="Farmer, Kyle" uniqKey="Farmer K" first="Kyle" last="Farmer">Kyle Farmer</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Catherine A" sort="Smith, Catherine A" uniqKey="Smith C" first="Catherine A." last="Smith">Catherine A. Smith</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Jeffrey" sort="Smith, Jeffrey" uniqKey="Smith J" first="Jeffrey" last="Smith">Jeffrey Smith</name><affiliation><nlm:aff id="af2-ijms-16-18865">Carleton University Department of Chemistry and Institute of Biochemistry, 1125 Colonel By Drive, Steacie Building, Ottawa, ON K1S 5B6, Canada; E-Mail:<email>jeff_smith@carleton.ca</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26274953</idno><idno type="pmc">4581276</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581276</idno><idno type="RBID">PMC:4581276</idno><idno type="doi">10.3390/ijms160818865</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000064</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000064</idno><idno type="wicri:Area/Pmc/Curation">000064</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000064</idno><idno type="wicri:Area/Pmc/Checkpoint">000268</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000268</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000441</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000441</idno><idno type="wicri:Area/PubMed/Curation">000441</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000441</idno><idno type="wicri:Area/PubMed/Checkpoint">000441</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000441</idno><idno type="wicri:Area/Ncbi/Merge">001C78</idno><idno type="wicri:Area/Ncbi/Curation">001C78</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C78</idno><idno type="wicri:Area/Main/Merge">000656</idno><idno type="wicri:Area/Main/Curation">000655</idno><idno type="wicri:Area/Main/Exploration">000655</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease</title><author><name sortKey="Farmer, Kyle" sort="Farmer, Kyle" uniqKey="Farmer K" first="Kyle" last="Farmer">Kyle Farmer</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Catherine A" sort="Smith, Catherine A" uniqKey="Smith C" first="Catherine A." last="Smith">Catherine A. Smith</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><affiliation><nlm:aff id="af1-ijms-16-18865">Carleton University Department of Neuroscience, 1125 Colonel By Drive, Life Sciences Research Building, Ottawa, ON K1S 5B6, Canada; E-Mails:<email>kyle_farmer@carleton.ca</email> (K.F.);<email>csmith@connect.carleton.ca</email> (C.A.S.)</nlm:aff></affiliation></author><author><name sortKey="Smith, Jeffrey" sort="Smith, Jeffrey" uniqKey="Smith J" first="Jeffrey" last="Smith">Jeffrey Smith</name><affiliation><nlm:aff id="af2-ijms-16-18865">Carleton University Department of Chemistry and Institute of Biochemistry, 1125 Colonel By Drive, Steacie Building, Ottawa, ON K1S 5B6, Canada; E-Mail:<email>jeff_smith@carleton.ca</email></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lipid Metabolism</term><term>Lysophosphatidylcholines (metabolism)</term><term>Male</term><term>Parkinson Disease (metabolism)</term><term>Phosphatidylcholines (metabolism)</term><term>Rats</term><term>Substantia Nigra (metabolism)</term><term>Tandem Mass Spectrometry</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lysophosphatidylcholines</term><term>Phosphatidylcholines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lipid Metabolism</term><term>Male</term><term>Rats</term><term>Tandem Mass Spectrometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting the nigrostriatal pathway, where patients do not manifest motor symptoms until >50% of neurons are lost. Thus, it is of great importance to determine early neuronal changes that may contribute to disease progression. Recent attention has focused on lipids and their role in pro- and anti-apoptotic processes. However, information regarding the lipid alterations in animal models of PD is lacking. In this study, we utilized high performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) and novel HPLC solvent methodology to profile phosphatidylcholines and sphingolipids within the substantia nigra. The ipsilateral substantia nigra pars compacta was collected from rats 21 days after an infusion of 6-hydroxydopamine (6-OHDA), or vehicle into the anterior dorsal striatum. We identified 115 lipid species from their mass/charge ratio using the LMAPS Lipid MS Predict Database. Of these, 19 lipid species (from phosphatidylcholine and lysophosphotidylcholine lipid classes) were significantly altered by 6-OHDA, with most being down-regulated. The two lipid species that were up-regulated were LPC (16:0) and LPC (18:1), which are important for neuroinflammatory signalling. These findings provide a first step in the characterization of lipid changes in early stages of PD-like pathology and could provide novel targets for early interventions in PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bernheimer, H" uniqKey="Bernheimer H">H. Bernheimer</name></author><author><name sortKey="Birkmayer, W" uniqKey="Birkmayer W">W. Birkmayer</name></author><author><name sortKey="Hornykiewicz, O" uniqKey="Hornykiewicz O">O. Hornykiewicz</name></author><author><name sortKey="Jellinger, K" uniqKey="Jellinger K">K. Jellinger</name></author><author><name sortKey="Seitelberger, F" uniqKey="Seitelberger F">F. Seitelberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klockgether, T" uniqKey="Klockgether T">T. Klockgether</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menza, M" uniqKey="Menza M">M. Menza</name></author><author><name sortKey="Donkin, R" uniqKey="Donkin R">R. Donkin</name></author><author><name sortKey="Marin, H" uniqKey="Marin H">H. Marin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marie, R" uniqKey="Marie R">R. Marié</name></author><author><name sortKey="Barre, L" uniqKey="Barre L">L. Barré</name></author><author><name sortKey="Dupuy, B" uniqKey="Dupuy B">B. Dupuy</name></author><author><name sortKey="Viader, F" uniqKey="Viader F">F. Viader</name></author><author><name sortKey="Defer, G" uniqKey="Defer G">G. Defer</name></author><author><name sortKey="Baron, J" uniqKey="Baron J">J. Baron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farmer, K" uniqKey="Farmer K">K. Farmer</name></author><author><name sortKey="Rudyk, C" uniqKey="Rudyk C">C. Rudyk</name></author><author><name sortKey="Prowse, N A" uniqKey="Prowse N">N.A. Prowse</name></author><author><name sortKey="Hayley, S" uniqKey="Hayley S">S. Hayley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perier, C" uniqKey="Perier C">C. Perier</name></author><author><name sortKey="Bove, J" uniqKey="Bove J">J. Bové</name></author><author><name sortKey="Wu, D C" uniqKey="Wu D">D.-C. Wu</name></author><author><name sortKey="Dehay, B" uniqKey="Dehay B">B. Dehay</name></author><author><name sortKey="Choi, D K" uniqKey="Choi D">D.-K. Choi</name></author><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V. Jackson-Lewis</name></author><author><name sortKey="Rathke Hartlieb, S" uniqKey="Rathke Hartlieb S">S. Rathke-Hartlieb</name></author><author><name sortKey="Bouillet, P" uniqKey="Bouillet P">P. Bouillet</name></author><author><name sortKey="Strasser, A" uniqKey="Strasser A">A. Strasser</name></author><author><name sortKey="Schulz, J B" uniqKey="Schulz J">J.B. Schulz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, B" uniqKey="Zheng B">B. Zheng</name></author><author><name sortKey="Liao, Z" uniqKey="Liao Z">Z. Liao</name></author><author><name sortKey="Locascio, J J" uniqKey="Locascio J">J.J. Locascio</name></author><author><name sortKey="Lesniak, K A" uniqKey="Lesniak K">K.A. Lesniak</name></author><author><name sortKey="Roderick, S S" uniqKey="Roderick S">S.S. Roderick</name></author><author><name sortKey="Watt, M L" uniqKey="Watt M">M.L. Watt</name></author><author><name sortKey="Eklund, A C" uniqKey="Eklund A">A.C. Eklund</name></author><author><name sortKey="Zhang James, Y" uniqKey="Zhang James Y">Y. Zhang-James</name></author><author><name sortKey="Kim, P D" uniqKey="Kim P">P.D. Kim</name></author><author><name sortKey="Hauser, M A" uniqKey="Hauser M">M.A. Hauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winklhofer, K F" uniqKey="Winklhofer K">K.F. Winklhofer</name></author><author><name sortKey="Haass, C" uniqKey="Haass C">C. Haass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagenah, J M" uniqKey="Hagenah J">J.M. Hagenah</name></author><author><name sortKey="Konig, I R" uniqKey="Konig I">I.R. König</name></author><author><name sortKey="Becker, B" uniqKey="Becker B">B. Becker</name></author><author><name sortKey="Hilker, R" uniqKey="Hilker R">R. Hilker</name></author><author><name sortKey="Kasten, M" uniqKey="Kasten M">M. Kasten</name></author><author><name sortKey="Hedrich, K" uniqKey="Hedrich K">K. Hedrich</name></author><author><name sortKey="Pramstaller, P P" uniqKey="Pramstaller P">P.P. Pramstaller</name></author><author><name sortKey="Klein, C" uniqKey="Klein C">C. Klein</name></author><author><name sortKey="Seidel, G" uniqKey="Seidel G">G. Seidel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schweitzer, K J" uniqKey="Schweitzer K">K.J. Schweitzer</name></author><author><name sortKey="Brussel, T" uniqKey="Brussel T">T. Brüssel</name></author><author><name sortKey="Leitner, P" uniqKey="Leitner P">P. Leitner</name></author><author><name sortKey="Kruger, R" uniqKey="Kruger R">R. Krüger</name></author><author><name sortKey="Bauer, P" uniqKey="Bauer P">P. Bauer</name></author><author><name sortKey="Woitalla, D" uniqKey="Woitalla D">D. Woitalla</name></author><author><name sortKey="Tomiuk, J" uniqKey="Tomiuk J">J. Tomiuk</name></author><author><name sortKey="Gasser, T" uniqKey="Gasser T">T. Gasser</name></author><author><name sortKey="Berg, D" uniqKey="Berg D">D. Berg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prasad, K" uniqKey="Prasad K">K. Prasad</name></author><author><name sortKey="Winnik, B" uniqKey="Winnik B">B. Winnik</name></author><author><name sortKey="Thiruchelvam, M J" uniqKey="Thiruchelvam M">M.J. Thiruchelvam</name></author><author><name sortKey="Buckley, B" uniqKey="Buckley B">B. Buckley</name></author><author><name sortKey="Mirochnitchenko, O" uniqKey="Mirochnitchenko O">O. Mirochnitchenko</name></author><author><name sortKey="Richfield, E K" uniqKey="Richfield E">E.K. Richfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goonesinghe, A" uniqKey="Goonesinghe A">A. Goonesinghe</name></author><author><name sortKey="Mundy, E S" uniqKey="Mundy E">E.S. Mundy</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M. Smith</name></author><author><name sortKey="Khosravi Far, R" uniqKey="Khosravi Far R">R. Khosravi-Far</name></author><author><name sortKey="Martinou, J C" uniqKey="Martinou J">J.-C. Martinou</name></author><author><name sortKey="Esposti, M D" uniqKey="Esposti M">M.D. Esposti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, Z" uniqKey="Qin Z">Z. Qin</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giussani, P" uniqKey="Giussani P">P. Giussani</name></author><author><name sortKey="Tringali, C" uniqKey="Tringali C">C. Tringali</name></author><author><name sortKey="Riboni, L" uniqKey="Riboni L">L. Riboni</name></author><author><name sortKey="Viani, P" uniqKey="Viani P">P. Viani</name></author><author><name sortKey="Venerando, B" uniqKey="Venerando B">B. Venerando</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, M M" uniqKey="Wright M">M.M. Wright</name></author><author><name sortKey="Howe, A G" uniqKey="Howe A">A.G. Howe</name></author><author><name sortKey="Zaremberg, V" uniqKey="Zaremberg V">V. Zaremberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gulshan, K" uniqKey="Gulshan K">K. Gulshan</name></author><author><name sortKey="Moye Rowley, W S" uniqKey="Moye Rowley W">W.S. Moye-Rowley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Treede, I" uniqKey="Treede I">I. Treede</name></author><author><name sortKey="Braun, A" uniqKey="Braun A">A. Braun</name></author><author><name sortKey="Sparla, R" uniqKey="Sparla R">R. Sparla</name></author><author><name sortKey="Kuhnel, M" uniqKey="Kuhnel M">M. Kühnel</name></author><author><name sortKey="Giese, T" uniqKey="Giese T">T. Giese</name></author><author><name sortKey="Turner, J R" uniqKey="Turner J">J.R. Turner</name></author><author><name sortKey="Anes, E" uniqKey="Anes E">E. Anes</name></author><author><name sortKey="Kulaksiz, H" uniqKey="Kulaksiz H">H. Kulaksiz</name></author><author><name sortKey="Fullekrug, J" uniqKey="Fullekrug J">J. Füllekrug</name></author><author><name sortKey="Stremmel, W" uniqKey="Stremmel W">W. Stremmel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marinova Mutafchieva, L" uniqKey="Marinova Mutafchieva L">L. Marinova-Mutafchieva</name></author><author><name sortKey="Sadeghian, M" uniqKey="Sadeghian M">M. Sadeghian</name></author><author><name sortKey="Broom, L" uniqKey="Broom L">L. Broom</name></author><author><name sortKey="Davis, J B" uniqKey="Davis J">J.B. Davis</name></author><author><name sortKey="Medhurst, A D" uniqKey="Medhurst A">A.D. Medhurst</name></author><author><name sortKey="Dexter, D T" uniqKey="Dexter D">D.T. Dexter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stott, S R W" uniqKey="Stott S">S.R.W. Stott</name></author><author><name sortKey="Barker, R A" uniqKey="Barker R">R.A. Barker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choudhury, M E" uniqKey="Choudhury M">M.E. Choudhury</name></author><author><name sortKey="Sugimoto, K" uniqKey="Sugimoto K">K. Sugimoto</name></author><author><name sortKey="Kubo, M" uniqKey="Kubo M">M. Kubo</name></author><author><name sortKey="Nagai, M" uniqKey="Nagai M">M. Nagai</name></author><author><name sortKey="Nomoto, M" uniqKey="Nomoto M">M. Nomoto</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H. Takahashi</name></author><author><name sortKey="Yano, H" uniqKey="Yano H">H. Yano</name></author><author><name sortKey="Tanaka, J" uniqKey="Tanaka J">J. Tanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandes, M S" uniqKey="Hernandes M">M.S. Hernandes</name></author><author><name sortKey="Santos, G D R" uniqKey="Santos G">G.D.R. Santos</name></author><author><name sortKey="Cafe Mendes, C C" uniqKey="Cafe Mendes C">C.C. Café-Mendes</name></author><author><name sortKey="Lima, L S" uniqKey="Lima L">L.S. Lima</name></author><author><name sortKey="Scavone, C" uniqKey="Scavone C">C. Scavone</name></author><author><name sortKey="Munhoz, C D" uniqKey="Munhoz C">C.D. Munhoz</name></author><author><name sortKey="Britto, L R G" uniqKey="Britto L">L.R.G. Britto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goes, A T R" uniqKey="Goes A">A.T.R. Goes</name></author><author><name sortKey="Souza, L C" uniqKey="Souza L">L.C. Souza</name></author><author><name sortKey="Filho, C B" uniqKey="Filho C">C.B. Filho</name></author><author><name sortKey="Del Fabbro, L" uniqKey="Del Fabbro L">L. del Fabbro</name></author><author><name sortKey="De Gomes, M G" uniqKey="De Gomes M">M.G. de Gomes</name></author><author><name sortKey="Boeira, S P" uniqKey="Boeira S">S.P. Boeira</name></author><author><name sortKey="Jesse, C R" uniqKey="Jesse C">C.R. Jesse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanrott, K" uniqKey="Hanrott K">K. Hanrott</name></author><author><name sortKey="Gudmunsen, L" uniqKey="Gudmunsen L">L. Gudmunsen</name></author><author><name sortKey="O Eill, M J" uniqKey="O Eill M">M.J. O’Neill</name></author><author><name sortKey="Wonnacott, S" uniqKey="Wonnacott S">S. Wonnacott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Argaud, L" uniqKey="Argaud L">L. Argaud</name></author><author><name sortKey="Prigent, A F" uniqKey="Prigent A">A.-F. Prigent</name></author><author><name sortKey="Chalabreysse, L" uniqKey="Chalabreysse L">L. Chalabreysse</name></author><author><name sortKey="Loufouat, J" uniqKey="Loufouat J">J. Loufouat</name></author><author><name sortKey="Lagarde, M" uniqKey="Lagarde M">M. Lagarde</name></author><author><name sortKey="Ovize, M" uniqKey="Ovize M">M. Ovize</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, M M" uniqKey="Wright M">M.M. Wright</name></author><author><name sortKey="Mcmaster, C R" uniqKey="Mcmaster C">C.R. McMaster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayakawa, T" uniqKey="Hayakawa T">T. Hayakawa</name></author><author><name sortKey="Chang, M C J" uniqKey="Chang M">M.C.J. Chang</name></author><author><name sortKey="Bell, J M" uniqKey="Bell J">J.M. Bell</name></author><author><name sortKey="Seeman, R" uniqKey="Seeman R">R. Seeman</name></author><author><name sortKey="Rapoport, S I" uniqKey="Rapoport S">S.I. Rapoport</name></author><author><name sortKey="Appel, N M" uniqKey="Appel N">N.M. Appel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H J" uniqKey="Lee H">H.-J. Lee</name></author><author><name sortKey="Bazinet, R P" uniqKey="Bazinet R">R.P. Bazinet</name></author><author><name sortKey="Rapoport, S I" uniqKey="Rapoport S">S.I. Rapoport</name></author><author><name sortKey="Bhattacharjee, A K" uniqKey="Bhattacharjee A">A.K. Bhattacharjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S J" uniqKey="Kim S">S.J. Kim</name></author><author><name sortKey="Gershov, D" uniqKey="Gershov D">D. Gershov</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X. Ma</name></author><author><name sortKey="Brot, N" uniqKey="Brot N">N. Brot</name></author><author><name sortKey="Elkon, K B" uniqKey="Elkon K">K.B. Elkon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaattela, M" uniqKey="Jaattela M">M. Jaattela</name></author><author><name sortKey="Benedict, M" uniqKey="Benedict M">M. Benedict</name></author><author><name sortKey="Tewari, M" uniqKey="Tewari M">M. Tewari</name></author><author><name sortKey="Shayman, J A" uniqKey="Shayman J">J.A. Shayman</name></author><author><name sortKey="Dixit, V M" uniqKey="Dixit V">V.M. Dixit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmad, A S" uniqKey="Ahmad A">A.S. Ahmad</name></author><author><name sortKey="Maruyama, T" uniqKey="Maruyama T">T. Maruyama</name></author><author><name sortKey="Narumiya, S" uniqKey="Narumiya S">S. Narumiya</name></author><author><name sortKey="Dore, S" uniqKey="Dore S">S. Doré</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreisler, A" uniqKey="Kreisler A">A. Kreisler</name></author><author><name sortKey="Gele, P" uniqKey="Gele P">P. Gelé</name></author><author><name sortKey="Wiart, J F" uniqKey="Wiart J">J.-F. Wiart</name></author><author><name sortKey="Lhermitte, M" uniqKey="Lhermitte M">M. Lhermitte</name></author><author><name sortKey="Destee, A" uniqKey="Destee A">A. Destée</name></author><author><name sortKey="Bordet, R" uniqKey="Bordet R">R. Bordet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ravnsjkjaer, K" uniqKey="Ravnsjkjaer K">K. Ravnsjkjaer</name></author><author><name sortKey="Frigerio, F" uniqKey="Frigerio F">F. Frigerio</name></author><author><name sortKey="Boegesen, M" uniqKey="Boegesen M">M. Boegesen</name></author><author><name sortKey="Nielsen, T" uniqKey="Nielsen T">T. Nielsen</name></author><author><name sortKey="Maechler, P" uniqKey="Maechler P">P. Maechler</name></author><author><name sortKey="Mandrup, S" uniqKey="Mandrup S">S. Mandrup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kupsch, A" uniqKey="Kupsch A">A. Kupsch</name></author><author><name sortKey="Schmidt, W" uniqKey="Schmidt W">W. Schmidt</name></author><author><name sortKey="Gizatullina, Z" uniqKey="Gizatullina Z">Z. Gizatullina</name></author><author><name sortKey="Debska Vielhaber, G" uniqKey="Debska Vielhaber G">G. Debska-Vielhaber</name></author><author><name sortKey="Voges, J" uniqKey="Voges J">J. Voges</name></author><author><name sortKey="Striggow, F" uniqKey="Striggow F">F. Striggow</name></author><author><name sortKey="Panther, P" uniqKey="Panther P">P. Panther</name></author><author><name sortKey="Schwegler, H" uniqKey="Schwegler H">H. Schwegler</name></author><author><name sortKey="Heinze, H J" uniqKey="Heinze H">H.-J. Heinze</name></author><author><name sortKey="Vielhaber, S" uniqKey="Vielhaber S">S. Vielhaber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, S Y" uniqKey="Park S">S.Y. Park</name></author><author><name sortKey="Kim, D Y" uniqKey="Kim D">D.Y. Kim</name></author><author><name sortKey="Kang, J K" uniqKey="Kang J">J.-K. Kang</name></author><author><name sortKey="Park, G" uniqKey="Park G">G. Park</name></author><author><name sortKey="Choi, Y W" uniqKey="Choi Y">Y.-W. Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, M M" uniqKey="Khan M">M.M. Khan</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A. Ahmad</name></author><author><name sortKey="Ishrat, T" uniqKey="Ishrat T">T. Ishrat</name></author><author><name sortKey="Khan, M B" uniqKey="Khan M">M.B. Khan</name></author><author><name sortKey="Hoda, M N" uniqKey="Hoda M">M.N. Hoda</name></author><author><name sortKey="Khuwaja, G" uniqKey="Khuwaja G">G. Khuwaja</name></author><author><name sortKey="Raza, S S" uniqKey="Raza S">S.S. Raza</name></author><author><name sortKey="Khan, A" uniqKey="Khan A">A. Khan</name></author><author><name sortKey="Javed, H" uniqKey="Javed H">H. Javed</name></author><author><name sortKey="Vaibhav, K" uniqKey="Vaibhav K">K. Vaibhav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asaithambi, A" uniqKey="Asaithambi A">A. Asaithambi</name></author><author><name sortKey="Ay, M" uniqKey="Ay M">M. Ay</name></author><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author><author><name sortKey="Gosh, A" uniqKey="Gosh A">A. Gosh</name></author><author><name sortKey="Anantharam, V" uniqKey="Anantharam V">V. Anantharam</name></author><author><name sortKey="Kanthasamy, A" uniqKey="Kanthasamy A">A. Kanthasamy</name></author><author><name sortKey="Kanthasamy, A G" uniqKey="Kanthasamy A">A.G. Kanthasamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunningham, T J" uniqKey="Cunningham T">T.J. Cunningham</name></author><author><name sortKey="Yao, L" uniqKey="Yao L">L. Yao</name></author><author><name sortKey="Lucena, A" uniqKey="Lucena A">A. Lucena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu Wu, Y" uniqKey="Liu Wu Y">Y. Liu-Wu</name></author><author><name sortKey="Hurt Camejo, E" uniqKey="Hurt Camejo E">E. Hurt-Camejo</name></author><author><name sortKey="Wiklund, O" uniqKey="Wiklund O">O. Wiklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goncalves, I" uniqKey="Goncalves I">I. Gonçalves</name></author><author><name sortKey="Edsfeldt, A" uniqKey="Edsfeldt A">A. Edsfeldt</name></author><author><name sortKey="Ko, N Y" uniqKey="Ko N">N.Y. Ko</name></author><author><name sortKey="Grufman, H" uniqKey="Grufman H">H. Grufman</name></author><author><name sortKey="Berg, K" uniqKey="Berg K">K. Berg</name></author><author><name sortKey="Bjorkbacka, H" uniqKey="Bjorkbacka H">H. Björkbacka</name></author><author><name sortKey="Nitulescu, M" uniqKey="Nitulescu M">M. Nitulescu</name></author><author><name sortKey="Persson, A" uniqKey="Persson A">A. Persson</name></author><author><name sortKey="Nilsson, M" uniqKey="Nilsson M">M. Nilsson</name></author><author><name sortKey="Prehn, C" uniqKey="Prehn C">C. Prehn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ryborg, A K" uniqKey="Ryborg A">A.K. Ryborg</name></author><author><name sortKey="Deleuran, B" uniqKey="Deleuran B">B. Deleuran</name></author><author><name sortKey="Thestrup Pedersen, K" uniqKey="Thestrup Pedersen K">K. Thestrup-Pedersen</name></author><author><name sortKey="Kragballe, K" uniqKey="Kragballe K">K. Kragballe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmurray, H F" uniqKey="Mcmurray H">H.F. McMurray</name></author><author><name sortKey="Parthasarathy, S" uniqKey="Parthasarathy S">S. Parthasarathy</name></author><author><name sortKey="Steinberg, D" uniqKey="Steinberg D">D. Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinn, M T" uniqKey="Quinn M">M.T. Quinn</name></author><author><name sortKey="Parthasarathy, S" uniqKey="Parthasarathy S">S. Parthasarathy</name></author><author><name sortKey="Steinberg, D" uniqKey="Steinberg D">D. Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fabelo, N" uniqKey="Fabelo N">N. Fabelo</name></author><author><name sortKey="Martin, V" uniqKey="Martin V">V. Martín</name></author><author><name sortKey="Santpere, G" uniqKey="Santpere G">G. Santpere</name></author><author><name sortKey="Marin, R" uniqKey="Marin R">R. Marín</name></author><author><name sortKey="Torrent, L" uniqKey="Torrent L">L. Torrent</name></author><author><name sortKey="Ferrer, I" uniqKey="Ferrer I">I. Ferrer</name></author><author><name sortKey="Diaz, M" uniqKey="Diaz M">M. Díaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braverman, N E" uniqKey="Braverman N">N.E. Braverman</name></author><author><name sortKey="Moser, A B" uniqKey="Moser A">A.B. Moser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lohmeyer, M" uniqKey="Lohmeyer M">M. Lohmeyer</name></author><author><name sortKey="Bittman, R" uniqKey="Bittman R">R. Bittman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dave, P C" uniqKey="Dave P">P.C. Dave</name></author><author><name sortKey="Billington, E" uniqKey="Billington E">E. Billington</name></author><author><name sortKey="Pan, Y L" uniqKey="Pan Y">Y.-L. Pan</name></author><author><name sortKey="Straus, S K" uniqKey="Straus S">S.K. Straus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Putten, H" uniqKey="Van Der Putten H">H. Van der Putten</name></author><author><name sortKey="Wiederhold, K H" uniqKey="Wiederhold K">K.H. Wiederhold</name></author><author><name sortKey="Probst, A" uniqKey="Probst A">A. Probst</name></author><author><name sortKey="Barbieri, S" uniqKey="Barbieri S">S. Barbieri</name></author><author><name sortKey="Mistl, C" uniqKey="Mistl C">C. Mistl</name></author><author><name sortKey="Danner, S" uniqKey="Danner S">S. Danner</name></author><author><name sortKey="Kauffmann, S" uniqKey="Kauffmann S">S. Kauffmann</name></author><author><name sortKey="Hofele, K" uniqKey="Hofele K">K. Hofele</name></author><author><name sortKey="Spooren, W P" uniqKey="Spooren W">W.P. Spooren</name></author><author><name sortKey="Ruegg, M A" uniqKey="Ruegg M">M.A. Ruegg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotharius, J" uniqKey="Lotharius J">J. Lotharius</name></author><author><name sortKey="Brundin, P" uniqKey="Brundin P">P. Brundin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galvin, J E" uniqKey="Galvin J">J.E. Galvin</name></author><author><name sortKey="Uryu, K" uniqKey="Uryu K">K. Uryu</name></author><author><name sortKey="Lee, V M" uniqKey="Lee V">V.M. Lee</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J.Q. Trojanowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, H" uniqKey="Cheng H">H. Cheng</name></author><author><name sortKey="Ulane, C" uniqKey="Ulane C">C. Ulane</name></author><author><name sortKey="Burke, R" uniqKey="Burke R">R. Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blandini, F" uniqKey="Blandini F">F. Blandini</name></author><author><name sortKey="Armentero, M T" uniqKey="Armentero M">M.T. Armentero</name></author><author><name sortKey="Martignoni, E" uniqKey="Martignoni E">E. Martignoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauer, H" uniqKey="Sauer H">H. Sauer</name></author><author><name sortKey="Oertel, W H" uniqKey="Oertel W">W.H. Oertel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandes, M S" uniqKey="Hernandes M">M.S. Hernandes</name></author><author><name sortKey="Cafe Mendes, C C" uniqKey="Cafe Mendes C">C.C. Café-Mendes</name></author><author><name sortKey="Britto, L R G" uniqKey="Britto L">L.R.G. Britto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Segura Aguilar, J" uniqKey="Segura Aguilar J">J. Segura-Aguilar</name></author><author><name sortKey="Kostrzewa, R M" uniqKey="Kostrzewa R">R.M. Kostrzewa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielke, M M" uniqKey="Mielke M">M.M. Mielke</name></author><author><name sortKey="Maetzler, W" uniqKey="Maetzler W">W. Maetzler</name></author><author><name sortKey="Haughey, N J" uniqKey="Haughey N">N.J. Haughey</name></author><author><name sortKey="Bandaru, V V R" uniqKey="Bandaru V">V.V.R. Bandaru</name></author><author><name sortKey="Savica, R" uniqKey="Savica R">R. Savica</name></author><author><name sortKey="Deuschle, C" uniqKey="Deuschle C">C. Deuschle</name></author><author><name sortKey="Gasser, T" uniqKey="Gasser T">T. Gasser</name></author><author><name sortKey="Hauser, A K" uniqKey="Hauser A">A.-K. Hauser</name></author><author><name sortKey="Gr Ber Sultan, S" uniqKey="Gr Ber Sultan S">S. Gräber-Sultan</name></author><author><name sortKey="Schleicher, E" uniqKey="Schleicher E">E. Schleicher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mapstone, M" uniqKey="Mapstone M">M. Mapstone</name></author><author><name sortKey="Cheema, A K" uniqKey="Cheema A">A.K. Cheema</name></author><author><name sortKey="Fiandaca, M S" uniqKey="Fiandaca M">M.S. Fiandaca</name></author><author><name sortKey="Zhong, X" uniqKey="Zhong X">X. Zhong</name></author><author><name sortKey="Mhyre, T R" uniqKey="Mhyre T">T.R. Mhyre</name></author><author><name sortKey="Macarthur, L H" uniqKey="Macarthur L">L.H. MacArthur</name></author><author><name sortKey="Hall, W J" uniqKey="Hall W">W.J. Hall</name></author><author><name sortKey="Fisher, S G" uniqKey="Fisher S">S.G. Fisher</name></author><author><name sortKey="Peterson, D R" uniqKey="Peterson D">D.R. Peterson</name></author><author><name sortKey="Haley, J M" uniqKey="Haley J">J.M. Haley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G. Paxinos</name></author><author><name sortKey="Watson, C" uniqKey="Watson C">C. Watson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Farmer, Kyle" sort="Farmer, Kyle" uniqKey="Farmer K" first="Kyle" last="Farmer">Kyle Farmer</name><name sortKey="Hayley, Shawn" sort="Hayley, Shawn" uniqKey="Hayley S" first="Shawn" last="Hayley">Shawn Hayley</name><name sortKey="Smith, Catherine A" sort="Smith, Catherine A" uniqKey="Smith C" first="Catherine A." last="Smith">Catherine A. Smith</name><name sortKey="Smith, Jeffrey" sort="Smith, Jeffrey" uniqKey="Smith J" first="Jeffrey" last="Smith">Jeffrey Smith</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000655 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000655 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4581276
|texte= Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26274953" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |