REM sleep behaviour disorder is associated with lower fast and higher slow sleep spindle densities.
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565REM sleep behaviour disorder is associated with lower fast and higher slow sleep spindle densities.
Auteurs : Christian O'Reilly [Canada] ; Isabelle Godin [Canada] ; Jacques Montplaisir [Canada] ; Tore Nielsen [Canada]Source :
- Journal of sleep research [ 1365-2869 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- physiology : Sleep.
- physiopathology : REM Sleep Behavior Disorder.
- Algorithms, Case-Control Studies, Electroencephalography, Electromyography, Electrooculography, Fasting, Female, Humans, Male, Middle Aged, Polysomnography.
Abstract
To investigate differences in sleep spindle properties and scalp topography between patients with rapid eye movement sleep behaviour disorder (RBD) and healthy controls, whole-night polysomnograms of 35 patients diagnosed with RBD and 35 healthy control subjects matched for age and sex were compared. Recordings included a 19-lead 10-20 electroencephalogram montage and standard electromyogram, electrooculogram, electrocardiogram and respiratory leads. Sleep spindles were automatically detected using a standard algorithm, and their characteristics (amplitude, duration, density, frequency and frequency slope) compared between groups. Topological analyses of group-discriminative features were conducted. Sleep spindles occurred at a significantly (e.g. t34 = -4.49; P = 0.00008 for C3) lower density (spindles ∙ min(-1) ) for RBD (mean ± SD: 1.61 ± 0.56 for C3) than for control (2.19 ± 0.61 for C3) participants. However, when distinguishing slow and fast spindles using thresholds individually adapted to the electroencephalogram spectrum of each participant, densities smaller (31-96%) for fast but larger (20-120%) for slow spindles were observed in RBD in all derivations. Maximal differences were in more posterior regions for slow spindles, but over the entire scalp for fast spindles. Results suggest that the density of sleep spindles is altered in patients with RBD and should therefore be investigated as a potential marker of future neurodegeneration in these patients.
DOI: 10.1111/jsr.12309
PubMed: 26041532
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000362
- to stream PubMed, to step Curation: 000362
- to stream PubMed, to step Checkpoint: 000362
- to stream Ncbi, to step Merge: 001B87
- to stream Ncbi, to step Curation: 001B87
- to stream Ncbi, to step Checkpoint: 001B87
- to stream Main, to step Merge: 000565
- to stream Main, to step Curation: 000564
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">REM sleep behaviour disorder is associated with lower fast and higher slow sleep spindle densities.</title><author><name sortKey="O Reilly, Christian" sort="O Reilly, Christian" uniqKey="O Reilly C" first="Christian" last="O'Reilly">Christian O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Godin, Isabelle" sort="Godin, Isabelle" uniqKey="Godin I" first="Isabelle" last="Godin">Isabelle Godin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Nielsen, Tore" sort="Nielsen, Tore" uniqKey="Nielsen T" first="Tore" last="Nielsen">Tore Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26041532</idno><idno type="pmid">26041532</idno><idno type="doi">10.1111/jsr.12309</idno><idno type="wicri:Area/PubMed/Corpus">000362</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000362</idno><idno type="wicri:Area/PubMed/Curation">000362</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000362</idno><idno type="wicri:Area/PubMed/Checkpoint">000362</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000362</idno><idno type="wicri:Area/Ncbi/Merge">001B87</idno><idno type="wicri:Area/Ncbi/Curation">001B87</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B87</idno><idno type="wicri:Area/Main/Merge">000565</idno><idno type="wicri:Area/Main/Curation">000564</idno><idno type="wicri:Area/Main/Exploration">000564</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">REM sleep behaviour disorder is associated with lower fast and higher slow sleep spindle densities.</title><author><name sortKey="O Reilly, Christian" sort="O Reilly, Christian" uniqKey="O Reilly C" first="Christian" last="O'Reilly">Christian O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Godin, Isabelle" sort="Godin, Isabelle" uniqKey="Godin I" first="Isabelle" last="Godin">Isabelle Godin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Nielsen, Tore" sort="Nielsen, Tore" uniqKey="Nielsen T" first="Tore" last="Nielsen">Tore Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of sleep research</title><idno type="eISSN">1365-2869</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Case-Control Studies</term><term>Electroencephalography</term><term>Electromyography</term><term>Electrooculography</term><term>Fasting</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>REM Sleep Behavior Disorder (physiopathology)</term><term>Sleep (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Case-Control Studies</term><term>Electroencephalography</term><term>Electromyography</term><term>Electrooculography</term><term>Fasting</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate differences in sleep spindle properties and scalp topography between patients with rapid eye movement sleep behaviour disorder (RBD) and healthy controls, whole-night polysomnograms of 35 patients diagnosed with RBD and 35 healthy control subjects matched for age and sex were compared. Recordings included a 19-lead 10-20 electroencephalogram montage and standard electromyogram, electrooculogram, electrocardiogram and respiratory leads. Sleep spindles were automatically detected using a standard algorithm, and their characteristics (amplitude, duration, density, frequency and frequency slope) compared between groups. Topological analyses of group-discriminative features were conducted. Sleep spindles occurred at a significantly (e.g. t34 = -4.49; P = 0.00008 for C3) lower density (spindles ∙ min(-1) ) for RBD (mean ± SD: 1.61 ± 0.56 for C3) than for control (2.19 ± 0.61 for C3) participants. However, when distinguishing slow and fast spindles using thresholds individually adapted to the electroencephalogram spectrum of each participant, densities smaller (31-96%) for fast but larger (20-120%) for slow spindles were observed in RBD in all derivations. Maximal differences were in more posterior regions for slow spindles, but over the entire scalp for fast spindles. Results suggest that the density of sleep spindles is altered in patients with RBD and should therefore be investigated as a potential marker of future neurodegeneration in these patients.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="O Reilly, Christian" sort="O Reilly, Christian" uniqKey="O Reilly C" first="Christian" last="O'Reilly">Christian O'Reilly</name></noRegion><name sortKey="Godin, Isabelle" sort="Godin, Isabelle" uniqKey="Godin I" first="Isabelle" last="Godin">Isabelle Godin</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Nielsen, Tore" sort="Nielsen, Tore" uniqKey="Nielsen T" first="Tore" last="Nielsen">Tore Nielsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000564 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000564 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26041532
|texte= REM sleep behaviour disorder is associated with lower fast and higher slow sleep spindle densities.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26041532" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |