Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice
Identifieur interne : 000557 ( Main/Exploration ); précédent : 000556; suivant : 000558Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice
Auteurs : R. E. K. Macpherson [Canada] ; P. Baumeister [Canada] ; W. T. Peppler ; D. C. Wright [Canada] ; J. P. Little [Canada]Source :
- Journal of Applied Physiology [ 8750-7587 ] ; 2015.
Abstract
Obesity and type 2 diabetes are significant risk factors in the development of neurodegenerative diseases, such as Alzheimer's disease. A variety of cellular mechanisms, such as altered Akt and AMPK and increased inflammatory signaling, contribute to neurodegeneration. Exercise training can improve markers of neurodegeneration, but the underlying mechanisms remain unknown. The purpose of this study was to determine the effects of a single bout of exercise on markers of neurodegeneration and inflammation in brains from mice fed a high-fat diet. Male C57BL/6 mice were fed a low (LFD; 10% kcal from lard)- or a high-fat diet (HFD; 60% kcal from lard) for 7 wk. HFD mice underwent an acute bout of exercise (treadmill running: 15 m/min, 5% incline, 120 min) followed by a recovery period of 2 h. The HFD increased body mass and glucose intolerance (both
Url:
DOI: 10.1152/japplphysiol.00299.2015
PubMed: 26404616
PubMed Central: 4816412
Affiliations:
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E. K." last="Macpherson">R. E. K. Macpherson</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff1">Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Baumeister, P" sort="Baumeister, P" uniqKey="Baumeister P" first="P." last="Baumeister">P. Baumeister</name><affiliation wicri:level="1"><nlm:aff id="aff2">School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Peppler, W T" sort="Peppler, W T" uniqKey="Peppler W" first="W. T." last="Peppler">W. T. Peppler</name></author><author><name sortKey="Wright, D C" sort="Wright, D C" uniqKey="Wright D" first="D. C." last="Wright">D. C. Wright</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff1">Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Little, J P" sort="Little, J P" uniqKey="Little J" first="J. P." last="Little">J. P. Little</name><affiliation wicri:level="1"><nlm:aff id="aff2">School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Applied Physiology</title><idno type="ISSN">8750-7587</idno><idno type="eISSN">1522-1601</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Obesity and type 2 diabetes are significant risk factors in the development of neurodegenerative diseases, such as Alzheimer's disease. A variety of cellular mechanisms, such as altered Akt and AMPK and increased inflammatory signaling, contribute to neurodegeneration. Exercise training can improve markers of neurodegeneration, but the underlying mechanisms remain unknown. The purpose of this study was to determine the effects of a single bout of exercise on markers of neurodegeneration and inflammation in brains from mice fed a high-fat diet. Male C57BL/6 mice were fed a low (LFD; 10% kcal from lard)- or a high-fat diet (HFD; 60% kcal from lard) for 7 wk. HFD mice underwent an acute bout of exercise (treadmill running: 15 m/min, 5% incline, 120 min) followed by a recovery period of 2 h. The HFD increased body mass and glucose intolerance (both <italic>P</italic> < 0.05). This was accompanied by an approximately twofold increase in the phosphorylation of Akt, ERK, and GSK in the cortex (<italic>P</italic> < 0.05). Following exercise, there was a decrease in beta-site amyloid precursor protein cleaving enzyme 1 (BACE1; <italic>P</italic> < 0.05) and activity (<italic>P</italic> < 0.001). This was accompanied by a reduction in AMPK phosphorylation, indicative of a decline in cellular stress (<italic>P</italic> < 0.05). Akt and ERK phosphorylation were decreased following exercise in HFD mice to a level similar to that of the LFD mice (<italic>P</italic> < 0.05). This study demonstrates that a single bout of exercise can reduce BACE1 content and activity independent of changes in adiposity. This effect is associated with reductions in Akt, ERK, and AMPK signaling in the cortex.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Peppler, W T" sort="Peppler, W T" uniqKey="Peppler W" first="W. T." last="Peppler">W. T. Peppler</name></noCountry><country name="Canada"><noRegion><name sortKey="Macpherson, R E K" sort="Macpherson, R E K" uniqKey="Macpherson R" first="R. E. K." last="Macpherson">R. E. K. Macpherson</name></noRegion><name sortKey="Baumeister, P" sort="Baumeister, P" uniqKey="Baumeister P" first="P." last="Baumeister">P. Baumeister</name><name sortKey="Little, J P" sort="Little, J P" uniqKey="Little J" first="J. P." last="Little">J. P. Little</name><name sortKey="Wright, D C" sort="Wright, D C" uniqKey="Wright D" first="D. C." last="Wright">D. C. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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