Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Identifieur interne : 000419 ( Main/Exploration ); précédent : 000418; suivant : 000420Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Auteurs : Plamena R. Angelova [Royaume-Uni] ; Marthe H. R. Ludtmann [Royaume-Uni] ; Mathew H. Horrocks [Royaume-Uni] ; Alexander Negoda [Canada] ; Nunilo Cremades [Royaume-Uni] ; David Klenerman [Royaume-Uni] ; Christopher M. Dobson [Royaume-Uni] ; Nicholas W. Wood [Royaume-Uni] ; Evgeny V. Pavlov [Canada, États-Unis] ; Sonia Gandhi [Royaume-Uni] ; Andrey Y. Abramov [Royaume-Uni]Source :
- Journal of Cell Science [ 0021-9533 ] ; 2016.
Abstract
Aggregation of α-synuclein leads to the formation of oligomeric intermediates that can interact with membranes to form pores. However, it is unknown how this leads to cell toxicity in Parkinson's disease. We investigated the species-specific effects of α-synuclein on Ca2+ signalling in primary neurons and astrocytes using live neuronal imaging and electrophysiology on artificial membranes. We demonstrate that α-synuclein induces an increase in basal intracellular Ca2+ in its unfolded monomeric state as well as in its oligomeric state. Electrophysiology of artificial membranes demonstrated that α-synuclein monomers induce irregular ionic currents, whereas α-synuclein oligomers induce rare discrete channel formation events. Despite the ability of monomeric α-synuclein to affect Ca2+ signalling, it is only the oligomeric form of α-synuclein that induces cell death. Oligomer-induced cell death was abolished by the exclusion of extracellular Ca2+, which prevented the α-synuclein-induced Ca2+ dysregulation. The findings of this study confirm that α-synuclein interacts with membranes to affect Ca2+ signalling in a structure-specific manner and the oligomeric β-sheet-rich α-synuclein species ultimately leads to Ca2+ dysregulation and Ca2+-dependent cell death.
Url:
DOI: 10.1242/jcs.180737
PubMed: 26989132
PubMed Central: 4893653
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000141
- to stream Pmc, to step Curation: 000141
- to stream Pmc, to step Checkpoint: 000154
- to stream PubMed, to step Corpus: 000237
- to stream PubMed, to step Curation: 000237
- to stream PubMed, to step Checkpoint: 000237
- to stream Ncbi, to step Merge: 001F07
- to stream Ncbi, to step Curation: 001F07
- to stream Ncbi, to step Checkpoint: 001F07
- to stream Main, to step Merge: 000420
- to stream Main, to step Curation: 000419
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ca<sup>2+</sup> is a key factor in α-synuclein-induced neurotoxicity</title><author><name sortKey="Angelova, Plamena R" sort="Angelova, Plamena R" uniqKey="Angelova P" first="Plamena R." last="Angelova">Plamena R. Angelova</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ludtmann, Marthe H R" sort="Ludtmann, Marthe H R" uniqKey="Ludtmann M" first="Marthe H. R." last="Ludtmann">Marthe H. R. Ludtmann</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horrocks, Mathew H" sort="Horrocks, Mathew H" uniqKey="Horrocks M" first="Mathew H." last="Horrocks">Mathew H. Horrocks</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negoda, Alexander" sort="Negoda, Alexander" uniqKey="Negoda A" first="Alexander" last="Negoda">Alexander Negoda</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Physiology and Biophysics</addr-line>,<institution>Dalhousie University</institution>,<addr-line>Halifax B3H 4R2</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cremades, Nunilo" sort="Cremades, Nunilo" uniqKey="Cremades N" first="Nunilo" last="Cremades">Nunilo Cremades</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klenerman, David" sort="Klenerman, David" uniqKey="Klenerman D" first="David" last="Klenerman">David Klenerman</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dobson, Christopher M" sort="Dobson, Christopher M" uniqKey="Dobson C" first="Christopher M." last="Dobson">Christopher M. Dobson</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pavlov, Evgeny V" sort="Pavlov, Evgeny V" uniqKey="Pavlov E" first="Evgeny V." last="Pavlov">Evgeny V. Pavlov</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Physiology and Biophysics</addr-line>,<institution>Dalhousie University</institution>,<addr-line>Halifax B3H 4R2</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>College of Dentistry, New York University</institution>,<addr-line>New York 10010</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gandhi, Sonia" sort="Gandhi, Sonia" uniqKey="Gandhi S" first="Sonia" last="Gandhi">Sonia Gandhi</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abramov, Andrey Y" sort="Abramov, Andrey Y" uniqKey="Abramov A" first="Andrey Y." last="Abramov">Andrey Y. Abramov</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26989132</idno><idno type="pmc">4893653</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893653</idno><idno type="RBID">PMC:4893653</idno><idno type="doi">10.1242/jcs.180737</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000141</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000141</idno><idno type="wicri:Area/Pmc/Curation">000141</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000141</idno><idno type="wicri:Area/Pmc/Checkpoint">000154</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000154</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000237</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000237</idno><idno type="wicri:Area/PubMed/Curation">000237</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000237</idno><idno type="wicri:Area/PubMed/Checkpoint">000237</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000237</idno><idno type="wicri:Area/Ncbi/Merge">001F07</idno><idno type="wicri:Area/Ncbi/Curation">001F07</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F07</idno><idno type="wicri:Area/Main/Merge">000420</idno><idno type="wicri:Area/Main/Curation">000419</idno><idno type="wicri:Area/Main/Exploration">000419</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ca<sup>2+</sup> is a key factor in α-synuclein-induced neurotoxicity</title><author><name sortKey="Angelova, Plamena R" sort="Angelova, Plamena R" uniqKey="Angelova P" first="Plamena R." last="Angelova">Plamena R. Angelova</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ludtmann, Marthe H R" sort="Ludtmann, Marthe H R" uniqKey="Ludtmann M" first="Marthe H. R." last="Ludtmann">Marthe H. R. Ludtmann</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Horrocks, Mathew H" sort="Horrocks, Mathew H" uniqKey="Horrocks M" first="Mathew H." last="Horrocks">Mathew H. Horrocks</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negoda, Alexander" sort="Negoda, Alexander" uniqKey="Negoda A" first="Alexander" last="Negoda">Alexander Negoda</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Physiology and Biophysics</addr-line>,<institution>Dalhousie University</institution>,<addr-line>Halifax B3H 4R2</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cremades, Nunilo" sort="Cremades, Nunilo" uniqKey="Cremades N" first="Nunilo" last="Cremades">Nunilo Cremades</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klenerman, David" sort="Klenerman, David" uniqKey="Klenerman D" first="David" last="Klenerman">David Klenerman</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dobson, Christopher M" sort="Dobson, Christopher M" uniqKey="Dobson C" first="Christopher M." last="Dobson">Christopher M. Dobson</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Chemistry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge CB2 1EW</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pavlov, Evgeny V" sort="Pavlov, Evgeny V" uniqKey="Pavlov E" first="Evgeny V." last="Pavlov">Evgeny V. Pavlov</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Physiology and Biophysics</addr-line>,<institution>Dalhousie University</institution>,<addr-line>Halifax B3H 4R2</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af4"><institution>College of Dentistry, New York University</institution>,<addr-line>New York 10010</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gandhi, Sonia" sort="Gandhi, Sonia" uniqKey="Gandhi S" first="Sonia" last="Gandhi">Sonia Gandhi</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abramov, Andrey Y" sort="Abramov, Andrey Y" uniqKey="Abramov A" first="Andrey Y." last="Abramov">Andrey Y. Abramov</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>UCL Institute of Neurology</institution>,<addr-line>Queen Square, London WC1N 3BG</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Cell Science</title><idno type="ISSN">0021-9533</idno><idno type="eISSN">1477-9137</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Aggregation of α-synuclein leads to the formation of oligomeric intermediates that can interact with membranes to form pores. However, it is unknown how this leads to cell toxicity in Parkinson's disease. We investigated the species-specific effects of α-synuclein on Ca<sup>2+</sup> signalling in primary neurons and astrocytes using live neuronal imaging and electrophysiology on artificial membranes. We demonstrate that α-synuclein induces an increase in basal intracellular Ca<sup>2+</sup> in its unfolded monomeric state as well as in its oligomeric state. Electrophysiology of artificial membranes demonstrated that α-synuclein monomers induce irregular ionic currents, whereas α-synuclein oligomers induce rare discrete channel formation events. Despite the ability of monomeric α-synuclein to affect Ca<sup>2+</sup> signalling, it is only the oligomeric form of α-synuclein that induces cell death. Oligomer-induced cell death was abolished by the exclusion of extracellular Ca<sup>2+</sup>, which prevented the α-synuclein-induced Ca<sup>2+</sup> dysregulation. The findings of this study confirm that α-synuclein interacts with membranes to affect Ca<sup>2+</sup> signalling in a structure-specific manner and the oligomeric β-sheet-rich α-synuclein species ultimately leads to Ca<sup>2+</sup> dysregulation and Ca<sup>2+</sup>-dependent cell death.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author><author><name sortKey="Canevari, L" uniqKey="Canevari L">L. Canevari</name></author><author><name sortKey="Duchen, M R" uniqKey="Duchen M">M. R. Duchen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author><author><name sortKey="Ionov, M" uniqKey="Ionov M">M. Ionov</name></author><author><name sortKey="Pavlov, E" uniqKey="Pavlov E">E. Pavlov</name></author><author><name sortKey="Duchen, M R" uniqKey="Duchen M">M. R. Duchen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angelova, P R" uniqKey="Angelova P">P. R. Angelova</name></author><author><name sortKey="Horrocks, M H" uniqKey="Horrocks M">M. H. Horrocks</name></author><author><name sortKey="Klenerman, D" uniqKey="Klenerman D">D. Klenerman</name></author><author><name sortKey="Gandhi, S" uniqKey="Gandhi S">S. Gandhi</name></author><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author><author><name sortKey="Shchepinov, M S" uniqKey="Shchepinov M">M. S. Shchepinov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, S" uniqKey="Buttner S">S. Buttner</name></author><author><name sortKey="Faes, L" uniqKey="Faes L">L. Faes</name></author><author><name sortKey="Reichelt, W N" uniqKey="Reichelt W">W. N. Reichelt</name></author><author><name sortKey="Broeskamp, F" uniqKey="Broeskamp F">F. Broeskamp</name></author><author><name sortKey="Habernig, L" uniqKey="Habernig L">L. Habernig</name></author><author><name sortKey="Benke, S" uniqKey="Benke S">S. Benke</name></author><author><name sortKey="Kourtis, N" uniqKey="Kourtis N">N. Kourtis</name></author><author><name sortKey="Ruli, D" uniqKey="Ruli D">D. Ruli</name></author><author><name sortKey="Carmona Gutierrez, D" uniqKey="Carmona Gutierrez D">D. Carmona-Gutierrez</name></author><author><name sortKey="Eisenberg, T" uniqKey="Eisenberg T">T. Eisenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, S W" uniqKey="Chen S">S. W. Chen</name></author><author><name sortKey="Drakulic, S" uniqKey="Drakulic S">S. Drakulic</name></author><author><name sortKey="Deas, E" uniqKey="Deas E">E. Deas</name></author><author><name sortKey="Ouberai, M" uniqKey="Ouberai M">M. Ouberai</name></author><author><name sortKey="Aprile, F A" uniqKey="Aprile F">F. A. Aprile</name></author><author><name sortKey="Arranz, R" uniqKey="Arranz R">R. Arranz</name></author><author><name sortKey="Ness, S" uniqKey="Ness S">S. Ness</name></author><author><name sortKey="Roodveldt, C" uniqKey="Roodveldt C">C. Roodveldt</name></author><author><name sortKey="Guilliams, T" uniqKey="Guilliams T">T. Guilliams</name></author><author><name sortKey="De Genst, E J" uniqKey="De Genst E">E. J. De-Genst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cookson, M R" uniqKey="Cookson M">M. R. Cookson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cremades, N" uniqKey="Cremades N">N. Cremades</name></author><author><name sortKey="Cohen, S I A" uniqKey="Cohen S">S. I. A. Cohen</name></author><author><name sortKey="Deas, E" uniqKey="Deas E">E. Deas</name></author><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author><author><name sortKey="Chen, A Y" uniqKey="Chen A">A. Y. Chen</name></author><author><name sortKey="Orte, A" uniqKey="Orte A">A. Orte</name></author><author><name sortKey="Sandal, M" uniqKey="Sandal M">M. Sandal</name></author><author><name sortKey="Clarke, R W" uniqKey="Clarke R">R. W. Clarke</name></author><author><name sortKey="Dunne, P" uniqKey="Dunne P">P. Dunne</name></author><author><name sortKey="Aprile, F A" uniqKey="Aprile F">F. A. Aprile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, K M" uniqKey="Danzer K">K. M. Danzer</name></author><author><name sortKey="Haasen, D" uniqKey="Haasen D">D. Haasen</name></author><author><name sortKey="Karow, A R" uniqKey="Karow A">A. R. Karow</name></author><author><name sortKey="Moussaud, S" uniqKey="Moussaud S">S. Moussaud</name></author><author><name sortKey="Habeck, M" uniqKey="Habeck M">M. Habeck</name></author><author><name sortKey="Giese, A" uniqKey="Giese A">A. Giese</name></author><author><name sortKey="Kretzschmar, H" uniqKey="Kretzschmar H">H. Kretzschmar</name></author><author><name sortKey="Hengerer, B" uniqKey="Hengerer B">B. Hengerer</name></author><author><name sortKey="Kostka, M" uniqKey="Kostka M">M. Kostka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deas, E" uniqKey="Deas E">E. Deas</name></author><author><name sortKey="Cremades, N" uniqKey="Cremades N">N. Cremades</name></author><author><name sortKey="Angelova, P R" uniqKey="Angelova P">P. R. Angelova</name></author><author><name sortKey="Ludtmann, M" uniqKey="Ludtmann M">M. Ludtmann</name></author><author><name sortKey="Yao, Z" uniqKey="Yao Z">Z. Yao</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Horrocks, M" uniqKey="Horrocks M">M. Horrocks</name></author><author><name sortKey="Banushi, B" uniqKey="Banushi B">B. Banushi</name></author><author><name sortKey="Little, D" uniqKey="Little D">D. Little</name></author><author><name sortKey="Devine, M" uniqKey="Devine M">M. Devine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desplats, P" uniqKey="Desplats P">P. Desplats</name></author><author><name sortKey="Lee, H J" uniqKey="Lee H">H.-J. Lee</name></author><author><name sortKey="Bae, E J" uniqKey="Bae E">E.-J. Bae</name></author><author><name sortKey="Patrick, C" uniqKey="Patrick C">C. Patrick</name></author><author><name sortKey="Rockenstein, E" uniqKey="Rockenstein E">E. Rockenstein</name></author><author><name sortKey="Crews, L" uniqKey="Crews L">L. Crews</name></author><author><name sortKey="Spencer, B" uniqKey="Spencer B">B. Spencer</name></author><author><name sortKey="Masliah, E" uniqKey="Masliah E">E. Masliah</name></author><author><name sortKey="Lee, S J" uniqKey="Lee S">S.-J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domijan, A M" uniqKey="Domijan A">A.-M. Domijan</name></author><author><name sortKey="Kovac, S" uniqKey="Kovac S">S. Kovac</name></author><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Follett, J" uniqKey="Follett J">J. Follett</name></author><author><name sortKey="Darlow, B" uniqKey="Darlow B">B. Darlow</name></author><author><name sortKey="Wong, M B" uniqKey="Wong M">M. B. Wong</name></author><author><name sortKey="Goodwin, J" uniqKey="Goodwin J">J. Goodwin</name></author><author><name sortKey="Pountney, D L" uniqKey="Pountney D">D. L. Pountney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, C" uniqKey="Hansen C">C. Hansen</name></author><author><name sortKey="Angot, E" uniqKey="Angot E">E. Angot</name></author><author><name sortKey="Bergstrom, A L" uniqKey="Bergstrom A">A.-L. Bergstrom</name></author><author><name sortKey="Steiner, J A" uniqKey="Steiner J">J. A. Steiner</name></author><author><name sortKey="Pieri, L" uniqKey="Pieri L">L. Pieri</name></author><author><name sortKey="Paul, G" uniqKey="Paul G">G. Paul</name></author><author><name sortKey="Outeiro, T F" uniqKey="Outeiro T">T. F. Outeiro</name></author><author><name sortKey="Melki, R" uniqKey="Melki R">R. Melki</name></author><author><name sortKey="Kallunki, P" uniqKey="Kallunki P">P. Kallunki</name></author><author><name sortKey="Fog, K" uniqKey="Fog K">K. Fog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyer, W" uniqKey="Hoyer W">W. Hoyer</name></author><author><name sortKey="Antony, T" uniqKey="Antony T">T. Antony</name></author><author><name sortKey="Cherny, D" uniqKey="Cherny D">D. Cherny</name></author><author><name sortKey="Heim, G" uniqKey="Heim G">G. Heim</name></author><author><name sortKey="Jovin, T M" uniqKey="Jovin T">T. M. Jovin</name></author><author><name sortKey="Subramaniam, V" uniqKey="Subramaniam V">V. Subramaniam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalia, L V" uniqKey="Kalia L">L. V. Kalia</name></author><author><name sortKey="Kalia, S K" uniqKey="Kalia S">S. K. Kalia</name></author><author><name sortKey="Mclean, P J" uniqKey="Mclean P">P. J. McLean</name></author><author><name sortKey="Lozano, A M" uniqKey="Lozano A">A. M. Lozano</name></author><author><name sortKey="Lang, A E" uniqKey="Lang A">A. E. Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kayed, R" uniqKey="Kayed R">R. Kayed</name></author><author><name sortKey="Sokolov, Y" uniqKey="Sokolov Y">Y. Sokolov</name></author><author><name sortKey="Edmonds, B" uniqKey="Edmonds B">B. Edmonds</name></author><author><name sortKey="Mcintire, T M" uniqKey="Mcintire T">T. M. McIntire</name></author><author><name sortKey="Milton, S C" uniqKey="Milton S">S. C. Milton</name></author><author><name sortKey="Hall, J E" uniqKey="Hall J">J. E. Hall</name></author><author><name sortKey="Glabe, C G" uniqKey="Glabe C">C. G. Glabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nath, S" uniqKey="Nath S">S. Nath</name></author><author><name sortKey="Goodwin, J" uniqKey="Goodwin J">J. Goodwin</name></author><author><name sortKey="Engelborghs, Y" uniqKey="Engelborghs Y">Y. Engelborghs</name></author><author><name sortKey="Pountney, D L" uniqKey="Pountney D">D. L. Pountney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quist, A" uniqKey="Quist A">A. Quist</name></author><author><name sortKey="Doudevski, I" uniqKey="Doudevski I">I. Doudevski</name></author><author><name sortKey="Lin, H" uniqKey="Lin H">H. Lin</name></author><author><name sortKey="Azimova, R" uniqKey="Azimova R">R. Azimova</name></author><author><name sortKey="Ng, D" uniqKey="Ng D">D. Ng</name></author><author><name sortKey="Frangione, B" uniqKey="Frangione B">B. Frangione</name></author><author><name sortKey="Kagan, B" uniqKey="Kagan B">B. Kagan</name></author><author><name sortKey="Ghiso, J" uniqKey="Ghiso J">J. Ghiso</name></author><author><name sortKey="Lal, R" uniqKey="Lal R">R. Lal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sokolov, Y" uniqKey="Sokolov Y">Y. Sokolov</name></author><author><name sortKey="Kozak, J A" uniqKey="Kozak J">J. A. Kozak</name></author><author><name sortKey="Kayed, R" uniqKey="Kayed R">R. Kayed</name></author><author><name sortKey="Chanturiya, A" uniqKey="Chanturiya A">A. Chanturiya</name></author><author><name sortKey="Glabe, C" uniqKey="Glabe C">C. Glabe</name></author><author><name sortKey="Hall, J E" uniqKey="Hall J">J. E. Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaarmann, A" uniqKey="Vaarmann A">A. Vaarmann</name></author><author><name sortKey="Gandhi, S" uniqKey="Gandhi S">S. Gandhi</name></author><author><name sortKey="Gourine, A V" uniqKey="Gourine A">A. V. Gourine</name></author><author><name sortKey="Abramov, A Y" uniqKey="Abramov A">A. Y. Abramov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volles, M J" uniqKey="Volles M">M. J. Volles</name></author><author><name sortKey="Lansbury, P T" uniqKey="Lansbury P">P. T. Lansbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volles, M J" uniqKey="Volles M">M. J. Volles</name></author><author><name sortKey="Lee, S J" uniqKey="Lee S">S.-J. Lee</name></author><author><name sortKey="Rochet, J C" uniqKey="Rochet J">J.-C. Rochet</name></author><author><name sortKey="Shtilerman, M D" uniqKey="Shtilerman M">M. D. Shtilerman</name></author><author><name sortKey="Ding, T T" uniqKey="Ding T">T. T. Ding</name></author><author><name sortKey="Kessler, J C" uniqKey="Kessler J">J. C. Kessler</name></author><author><name sortKey="Lansbury, P T" uniqKey="Lansbury P">P. T. Lansbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volpicelli Daley, L A" uniqKey="Volpicelli Daley L">L. A. Volpicelli-Daley</name></author><author><name sortKey="Luk, K C" uniqKey="Luk K">K. C. Luk</name></author><author><name sortKey="Patel, T P" uniqKey="Patel T">T. P. Patel</name></author><author><name sortKey="Tanik, S A" uniqKey="Tanik S">S. A. Tanik</name></author><author><name sortKey="Riddle, D M" uniqKey="Riddle D">D. M. Riddle</name></author><author><name sortKey="Stieber, A" uniqKey="Stieber A">A. Stieber</name></author><author><name sortKey="Meaney, D F" uniqKey="Meaney D">D. F. Meaney</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J. Q. Trojanowski</name></author><author><name sortKey="Lee, V M Y" uniqKey="Lee V">V. M.-Y. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winner, B" uniqKey="Winner B">B. Winner</name></author><author><name sortKey="Jappelli, R" uniqKey="Jappelli R">R. Jappelli</name></author><author><name sortKey="Maji, S K" uniqKey="Maji S">S. K. Maji</name></author><author><name sortKey="Desplats, P A" uniqKey="Desplats P">P. A. Desplats</name></author><author><name sortKey="Boyer, L" uniqKey="Boyer L">L. Boyer</name></author><author><name sortKey="Aigner, S" uniqKey="Aigner S">S. Aigner</name></author><author><name sortKey="Hetzer, C" uniqKey="Hetzer C">C. Hetzer</name></author><author><name sortKey="Loher, T" uniqKey="Loher T">T. Loher</name></author><author><name sortKey="Vilar, M" uniqKey="Vilar M">M. Vilar</name></author><author><name sortKey="Campioni, S" uniqKey="Campioni S">S. Campioni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakharov, S D" uniqKey="Zakharov S">S. D. Zakharov</name></author><author><name sortKey="Hulleman, J D" uniqKey="Hulleman J">J. D. Hulleman</name></author><author><name sortKey="Dutseva, E A" uniqKey="Dutseva E">E. A. Dutseva</name></author><author><name sortKey="Antonenko, Y N" uniqKey="Antonenko Y">Y. N. Antonenko</name></author><author><name sortKey="Rochet, J C" uniqKey="Rochet J">J.-C. Rochet</name></author><author><name sortKey="Cramer, W A" uniqKey="Cramer W">W. A. Cramer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Angelova, Plamena R" sort="Angelova, Plamena R" uniqKey="Angelova P" first="Plamena R." last="Angelova">Plamena R. Angelova</name></noRegion><name sortKey="Abramov, Andrey Y" sort="Abramov, Andrey Y" uniqKey="Abramov A" first="Andrey Y." last="Abramov">Andrey Y. Abramov</name><name sortKey="Cremades, Nunilo" sort="Cremades, Nunilo" uniqKey="Cremades N" first="Nunilo" last="Cremades">Nunilo Cremades</name><name sortKey="Dobson, Christopher M" sort="Dobson, Christopher M" uniqKey="Dobson C" first="Christopher M." last="Dobson">Christopher M. Dobson</name><name sortKey="Gandhi, Sonia" sort="Gandhi, Sonia" uniqKey="Gandhi S" first="Sonia" last="Gandhi">Sonia Gandhi</name><name sortKey="Horrocks, Mathew H" sort="Horrocks, Mathew H" uniqKey="Horrocks M" first="Mathew H." last="Horrocks">Mathew H. Horrocks</name><name sortKey="Klenerman, David" sort="Klenerman, David" uniqKey="Klenerman D" first="David" last="Klenerman">David Klenerman</name><name sortKey="Ludtmann, Marthe H R" sort="Ludtmann, Marthe H R" uniqKey="Ludtmann M" first="Marthe H. R." last="Ludtmann">Marthe H. R. Ludtmann</name><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></country><country name="Canada"><noRegion><name sortKey="Negoda, Alexander" sort="Negoda, Alexander" uniqKey="Negoda A" first="Alexander" last="Negoda">Alexander Negoda</name></noRegion><name sortKey="Pavlov, Evgeny V" sort="Pavlov, Evgeny V" uniqKey="Pavlov E" first="Evgeny V." last="Pavlov">Evgeny V. Pavlov</name></country><country name="États-Unis"><noRegion><name sortKey="Pavlov, Evgeny V" sort="Pavlov, Evgeny V" uniqKey="Pavlov E" first="Evgeny V." last="Pavlov">Evgeny V. Pavlov</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000419 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000419 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4893653
|texte= Ca2+ is a key factor in α-synuclein-induced neurotoxicity
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26989132" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |