Guanosine and its role in neuropathologies
Identifieur interne : 000336 ( Main/Exploration ); précédent : 000335; suivant : 000337Guanosine and its role in neuropathologies
Auteurs : Luis E. B. Bettio ; Joana Gil-Mohapel ; Ana Lúcia S. RodriguesSource :
- Purinergic Signalling [ 1573-9538 ] ; 2016.
Abstract
Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. In agreement, guanosine was shown to be protective in several in vitro and/or in vivo experimental models of central nervous system (CNS) diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. The mechanisms underlying the neurobiological properties of guanosine seem to involve the activation of several intracellular signaling pathways and a close interaction with the adenosinergic system, with a consequent stimulation of neuroprotective and regenerative processes in the CNS. Within this context, the present review will provide an overview of the current literature on the effects of guanosine in the CNS. The elucidation of the complex signaling events underlying the biochemical and cellular effects of this nucleoside may further establish guanosine as a potential therapeutic target for the treatment of several neuropathologies.
Url:
DOI: 10.1007/s11302-016-9509-4
PubMed: 27002712
PubMed Central: 5023624
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000221
- to stream Pmc, to step Curation: 000221
- to stream Pmc, to step Checkpoint: 000117
- to stream Ncbi, to step Merge: 001F10
- to stream Ncbi, to step Curation: 001F10
- to stream Ncbi, to step Checkpoint: 001F10
- to stream Main, to step Merge: 000337
- to stream Main, to step Curation: 000336
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Guanosine and its role in neuropathologies</title><author><name sortKey="Bettio, Luis E B" sort="Bettio, Luis E B" uniqKey="Bettio L" first="Luis E. B." last="Bettio">Luis E. B. Bettio</name><affiliation><nlm:aff id="Aff1">Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianópolis, SC Brazil</nlm:aff><wicri:noCountry code="subfield">SC Brazil</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC V8W 2Y2 Canada</nlm:aff><wicri:noCountry code="subfield">BC V8W 2Y2 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gil Mohapel, Joana" sort="Gil Mohapel, Joana" uniqKey="Gil Mohapel J" first="Joana" last="Gil-Mohapel">Joana Gil-Mohapel</name><affiliation><nlm:aff id="Aff2">Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC V8W 2Y2 Canada</nlm:aff><wicri:noCountry code="subfield">BC V8W 2Y2 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Rodrigues, Ana Lucia S" sort="Rodrigues, Ana Lucia S" uniqKey="Rodrigues A" first="Ana Lúcia S." last="Rodrigues">Ana Lúcia S. Rodrigues</name><affiliation><nlm:aff id="Aff1">Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianópolis, SC Brazil</nlm:aff><wicri:noCountry code="subfield">SC Brazil</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27002712</idno><idno type="pmc">5023624</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023624</idno><idno type="RBID">PMC:5023624</idno><idno type="doi">10.1007/s11302-016-9509-4</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000221</idno><idno type="wicri:Area/Pmc/Curation">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000221</idno><idno type="wicri:Area/Pmc/Checkpoint">000117</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000117</idno><idno type="wicri:Area/Ncbi/Merge">001F10</idno><idno type="wicri:Area/Ncbi/Curation">001F10</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F10</idno><idno type="wicri:doubleKey">1573-9538:2016:Bettio L:guanosine:and:its</idno><idno type="wicri:Area/Main/Merge">000337</idno><idno type="wicri:Area/Main/Curation">000336</idno><idno type="wicri:Area/Main/Exploration">000336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Guanosine and its role in neuropathologies</title><author><name sortKey="Bettio, Luis E B" sort="Bettio, Luis E B" uniqKey="Bettio L" first="Luis E. B." last="Bettio">Luis E. B. Bettio</name><affiliation><nlm:aff id="Aff1">Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianópolis, SC Brazil</nlm:aff><wicri:noCountry code="subfield">SC Brazil</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC V8W 2Y2 Canada</nlm:aff><wicri:noCountry code="subfield">BC V8W 2Y2 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Gil Mohapel, Joana" sort="Gil Mohapel, Joana" uniqKey="Gil Mohapel J" first="Joana" last="Gil-Mohapel">Joana Gil-Mohapel</name><affiliation><nlm:aff id="Aff2">Division of Medical Sciences and UBC Island Medical Program, University of Victoria, Victoria, BC V8W 2Y2 Canada</nlm:aff><wicri:noCountry code="subfield">BC V8W 2Y2 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Rodrigues, Ana Lucia S" sort="Rodrigues, Ana Lucia S" uniqKey="Rodrigues A" first="Ana Lúcia S." last="Rodrigues">Ana Lúcia S. Rodrigues</name><affiliation><nlm:aff id="Aff1">Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianópolis, SC Brazil</nlm:aff><wicri:noCountry code="subfield">SC Brazil</wicri:noCountry></affiliation></author></analytic><series><title level="j">Purinergic Signalling</title><idno type="ISSN">1573-9538</idno><idno type="eISSN">1573-9546</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released in the brain under physiological conditions and even more during pathological events, reducing neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. In agreement, guanosine was shown to be protective in several in vitro and/or in vivo experimental models of central nervous system (CNS) diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. The mechanisms underlying the neurobiological properties of guanosine seem to involve the activation of several intracellular signaling pathways and a close interaction with the adenosinergic system, with a consequent stimulation of neuroprotective and regenerative processes in the CNS. Within this context, the present review will provide an overview of the current literature on the effects of guanosine in the CNS. The elucidation of the complex signaling events underlying the biochemical and cellular effects of this nucleoside may further establish guanosine as a potential therapeutic target for the treatment of several neuropathologies.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bettio, Luis E B" sort="Bettio, Luis E B" uniqKey="Bettio L" first="Luis E. B." last="Bettio">Luis E. B. Bettio</name><name sortKey="Gil Mohapel, Joana" sort="Gil Mohapel, Joana" uniqKey="Gil Mohapel J" first="Joana" last="Gil-Mohapel">Joana Gil-Mohapel</name><name sortKey="Rodrigues, Ana Lucia S" sort="Rodrigues, Ana Lucia S" uniqKey="Rodrigues A" first="Ana Lúcia S." last="Rodrigues">Ana Lúcia S. Rodrigues</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000336 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000336 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5023624
|texte= Guanosine and its role in neuropathologies
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27002712" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |