Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
Identifieur interne : 000232 ( Main/Exploration ); précédent : 000231; suivant : 000233Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
Auteurs : Panying Rong [États-Unis] ; Yana Yunusova [Canada] ; Jun Wang [États-Unis] ; Lorne Zinman [Canada] ; Gary L. Pattee [États-Unis] ; James D. Berry [États-Unis] ; Bridget Perry [États-Unis] ; Jordan R. Green [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.
Url:
DOI: 10.1371/journal.pone.0154971
PubMed: 27148967
PubMed Central: 4858181
Affiliations:
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Pattee</name><affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Neurology Associates, P.C., Lincoln, Nebraska, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology Associates, P.C., Lincoln, Nebraska</wicri:regionArea><placeName><region type="state">Nebraska</region></placeName></affiliation></author><author><name sortKey="Berry, James D" sort="Berry, James D" uniqKey="Berry J" first="James D." last="Berry">James D. Berry</name><affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Massachusetts General Hospital, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Perry, Bridget" sort="Perry, Bridget" uniqKey="Perry B" first="Bridget" last="Perry">Bridget Perry</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Green, Jordan R" sort="Green, Jordan R" uniqKey="Green J" first="Jordan R." last="Green">Jordan R. Green</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Purpose</title><p>To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.</p></sec><sec id="sec002"><title>Method</title><p>Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.</p></sec><sec id="sec003"><title>Results</title><p>Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).</p></sec><sec id="sec004"><title>Conclusion</title><p>Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kent, Rd" uniqKey="Kent R">RD Kent</name></author><author><name sortKey="Weismer, G" uniqKey="Weismer G">G Weismer</name></author><author><name sortKey="Kent, Jf" uniqKey="Kent J">JF Kent</name></author><author><name sortKey="Rosenbek, Jc" uniqKey="Rosenbek J">JC Rosenbek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kent, Rd" uniqKey="Kent R">RD Kent</name></author><author><name sortKey="Kent, Jf" uniqKey="Kent J">JF Kent</name></author><author><name sortKey="Weismer, G" uniqKey="Weismer G">G Weismer</name></author><author><name sortKey="Sufit, Rl" uniqKey="Sufit R">RL Sufit</name></author><author><name sortKey="Rosenbek, Jc" uniqKey="Rosenbek J">JC Rosenbek</name></author><author><name sortKey="Martin, Re" 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sortKey="Kent, Rd" uniqKey="Kent R">RD Kent</name></author><author><name sortKey="Kent, Jf" uniqKey="Kent J">JF Kent</name></author><author><name sortKey="Rosenbek, Jc" uniqKey="Rosenbek J">JC Rosenbek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rong, P" uniqKey="Rong P">P Rong</name></author><author><name sortKey="Kuehn, D" uniqKey="Kuehn D">D Kuehn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggarwal, S" uniqKey="Aggarwal S">S Aggarwal</name></author><author><name sortKey="Cudkowicz, M" uniqKey="Cudkowicz M">M Cudkowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blain, Cr" uniqKey="Blain C">CR Blain</name></author><author><name sortKey="Williams, Vc" uniqKey="Williams V">VC Williams</name></author><author><name sortKey="Johnson, C" uniqKey="Johnson C">C Johnson</name></author><author><name sortKey="Stanton, Br" uniqKey="Stanton B">BR Stanton</name></author><author><name sortKey="Ganesalingam, J" uniqKey="Ganesalingam J">J Ganesalingam</name></author><author><name sortKey="Jarosz, Jm" uniqKey="Jarosz J">JM Jarosz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rong, P" uniqKey="Rong P">P Rong</name></author><author><name sortKey="Yunusova, Y" uniqKey="Yunusova Y">Y Yunusova</name></author><author><name sortKey="Green, Jr" uniqKey="Green J">JR Green</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Nebraska</li><li>Ontario</li><li>Texas</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Rong, Panying" sort="Rong, Panying" uniqKey="Rong P" first="Panying" last="Rong">Panying Rong</name></region><name sortKey="Berry, James D" sort="Berry, James D" uniqKey="Berry J" first="James D." last="Berry">James D. Berry</name><name sortKey="Green, Jordan R" sort="Green, Jordan R" uniqKey="Green J" first="Jordan R." last="Green">Jordan R. Green</name><name sortKey="Pattee, Gary L" sort="Pattee, Gary L" uniqKey="Pattee G" first="Gary L." last="Pattee">Gary L. Pattee</name><name sortKey="Perry, Bridget" sort="Perry, Bridget" uniqKey="Perry B" first="Bridget" last="Perry">Bridget Perry</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name></country><country name="Canada"><region name="Ontario"><name sortKey="Yunusova, Yana" sort="Yunusova, Yana" uniqKey="Yunusova Y" first="Yana" last="Yunusova">Yana Yunusova</name></region><name sortKey="Zinman, Lorne" sort="Zinman, Lorne" uniqKey="Zinman L" first="Lorne" last="Zinman">Lorne Zinman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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