Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
Identifieur interne : 000023 ( Main/Exploration ); précédent : 000022; suivant : 000024Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
Auteurs : D. Gagnon [Canada] ; S. Petryszyn [Canada] ; M. G. Sanchez [Canada] ; C. Bories [Canada] ; J. M. Beaulieu [Canada] ; Y. De Koninck [Canada] ; A. Parent [Canada] ; M. Parent [Canada]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 or D2 dopamine receptor. Consequences on MSNs expressing both receptors (D1/D2 MSNs) are currently unknown. We looked for changes induced by dopamine denervation in the density, regional distribution and morphological features of D1/D2 MSNs, by comparing 6-OHDA-lesioned double BAC transgenic mice (
Url:
DOI: 10.1038/srep41432
PubMed: 28128287
PubMed Central: 5269744
Affiliations:
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Sanchez</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bories, C" sort="Bories, C" uniqKey="Bories C" first="C." last="Bories">C. 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De Koninck</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Parent, A" sort="Parent, A" uniqKey="Parent A" first="A." last="Parent">A. 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Gagnon</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Petryszyn, S" sort="Petryszyn, S" uniqKey="Petryszyn S" first="S." last="Petryszyn">S. Petryszyn</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez, M G" sort="Sanchez, M G" uniqKey="Sanchez M" first="M. G." last="Sanchez">M. G. Sanchez</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bories, C" sort="Bories, C" uniqKey="Bories C" first="C." last="Bories">C. Bories</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beaulieu, J M" sort="Beaulieu, J M" uniqKey="Beaulieu J" first="J. M." last="Beaulieu">J. M. Beaulieu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Koninck, Y" sort="De Koninck, Y" uniqKey="De Koninck Y" first="Y." last="De Koninck">Y. De Koninck</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Parent, A" sort="Parent, A" uniqKey="Parent A" first="A." last="Parent">A. Parent</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Parent, M" sort="Parent, M" uniqKey="Parent M" first="M." last="Parent">M. Parent</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Centre de recherche de l’Institut universitaire en santé mentale de Québec, Department of Psychiatry and Neuroscience, Faculty of medicine, Université Laval</institution>, Quebec City, QC,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The loss of nigrostriatal dopamine neurons in Parkinson’s disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D<sub>1</sub> or D<sub>2</sub> dopamine receptor. Consequences on MSNs expressing both receptors (D<sub>1</sub>/D<sub>2</sub> MSNs) are currently unknown. We looked for changes induced by dopamine denervation in the density, regional distribution and morphological features of D<sub>1</sub>/D<sub>2</sub> MSNs, by comparing 6-OHDA-lesioned double BAC transgenic mice (<italic>Drd1a</italic>-tdTomato/<italic>Drd2</italic>-EGFP) to sham-lesioned animals. D<sub>1</sub>/D<sub>2</sub> MSNs are uniformly distributed throughout the dorsal striatum (1.9% of MSNs). In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core). Compared to D<sub>1</sub> and D<sub>2</sub> MSNs, D<sub>1</sub>/D<sub>2</sub> MSNs are endowed with a smaller cell body and a less profusely arborized dendritic tree with less dendritic spines. The dendritic spine density of D<sub>1</sub>/D<sub>2</sub> MSNs, but also of D<sub>1</sub> and D<sub>2</sub> MSNs, is significantly reduced in 6-OHDA-lesioned mice. In contrast to D<sub>1</sub> and D<sub>2</sub> MSNs, the extent of dendritic arborization of D<sub>1</sub>/D<sub>2</sub> MSNs appears unaltered in 6-OHDA-lesioned mice. Our data indicate that D<sub>1</sub>/D<sub>2</sub> MSNs in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson’s disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Graveland, G A" uniqKey="Graveland G">G. A. Graveland</name></author><author><name sortKey="Difiglia, M" uniqKey="Difiglia M">M. DiFiglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerfen, C R" uniqKey="Gerfen C">C. R. 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De Koninck</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Gagnon, D" sort="Gagnon, D" uniqKey="Gagnon D" first="D." last="Gagnon">D. Gagnon</name></noRegion><name sortKey="Beaulieu, J M" sort="Beaulieu, J M" uniqKey="Beaulieu J" first="J. M." last="Beaulieu">J. M. Beaulieu</name><name sortKey="Bories, C" sort="Bories, C" uniqKey="Bories C" first="C." last="Bories">C. Bories</name><name sortKey="De Koninck, Y" sort="De Koninck, Y" uniqKey="De Koninck Y" first="Y." last="De Koninck">Y. De Koninck</name><name sortKey="Parent, A" sort="Parent, A" uniqKey="Parent A" first="A." last="Parent">A. Parent</name><name sortKey="Parent, M" sort="Parent, M" uniqKey="Parent M" first="M." last="Parent">M. Parent</name><name sortKey="Petryszyn, S" sort="Petryszyn, S" uniqKey="Petryszyn S" first="S." last="Petryszyn">S. 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