Dementia, parkinsonism, and motor neuron disease: Neurochemical and neuropathological correlates
Identifieur interne : 004C30 ( Main/Curation ); précédent : 004C29; suivant : 004C31Dementia, parkinsonism, and motor neuron disease: Neurochemical and neuropathological correlates
Auteurs : Douglas S. Gilbert [Canada] ; Stephen J. Kish [Canada] ; Li-Jan Chang [Canada] ; Caryl Morito [Canada] ; Kathleen Shannak [Canada] ; Oleh Hornykiewicz [Canada, Autriche]Source :
- Annals of Neurology [ 0364-5134 ] ; 1988-11.
English descriptors
- KwdEn :
- Caudate Nucleus (analysis), Caudate Nucleus (pathology), Cerebellum (analysis), Cerebellum (pathology), Dementia (complications), Dementia (metabolism), Dementia (pathology), Frontal Lobe (analysis), Frontal Lobe (pathology), Humans, Male, Middle Aged, Neuromuscular Diseases (complications), Neuromuscular Diseases (metabolism), Neuromuscular Diseases (pathology), Neurotransmitter Agents (analysis), Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson Disease (pathology), Spinal Cord (analysis), Spinal Cord (pathology), Syndrome.
- MESH :
- chemical , analysis : Neurotransmitter Agents.
- analysis : Caudate Nucleus, Cerebellum, Frontal Lobe, Spinal Cord.
- complications : Dementia, Neuromuscular Diseases, Parkinson Disease.
- metabolism : Dementia, Neuromuscular Diseases, Parkinson Disease.
- pathology : Caudate Nucleus, Cerebellum, Dementia, Frontal Lobe, Neuromuscular Diseases, Parkinson Disease, Spinal Cord.
- Humans, Male, Middle Aged, Syndrome.
Abstract
The neurochemical Marchkers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia‐parkinsonism‐motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.
Url:
DOI: 10.1002/ana.410240518
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Douglas S. Gilbert<affiliation><wicri:noCountry code="subField">4G5</wicri:noCountry>
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Le document en format XML
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<term>Dementia (complications)</term>
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<front><div type="abstract" xml:lang="en">The neurochemical Marchkers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia‐parkinsonism‐motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.</div>
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