Increasing the in vitro bile acid binding capacity of diethylaminoethylcellulose by quaternization
Identifieur interne : 004777 ( Main/Curation ); précédent : 004776; suivant : 004778Increasing the in vitro bile acid binding capacity of diethylaminoethylcellulose by quaternization
Auteurs : S. Clas [Canada]Source :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1991-09.
Abstract
Diethylaminoethylcellulose (DEAE‐cellulose) was quaternized with methyl iodide (DEAE‐cellulose‐CH3l), and its in vitro binding capacity for sodium glycocholate, at room temperature, in water, Tris‐HCI buffer (0.0015–0.0050 M, pH 7.0), and aqueous NaCl (0.0025 M) was determined by reversed‐phase HPLC. Quaternization increased the in vitro bile salt binding capacity of DEAE‐cellulose. On a molar basis, the binding capacity was greater than that of cholestyramine, a cholesterollowering agent. Increasing the ionic strength of the medium decreased the binding capacities, as expected if ionic interactions are important. However, conversion of DEAE‐cellulose‐CH3l to its chloride form did not change the binding capacity. The bile salt binding capacity of DEAE‐cellulose‐CH3l was similar for both sodium cholate and sodium glycocholate.
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DOI: 10.1002/jps.2600800918
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