Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
Identifieur interne : 004242 ( Main/Curation ); précédent : 004241; suivant : 004243Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
Auteurs : I. Moroo [Japon] ; T. Yamada [Japon] ; H. Makino [Japon] ; I. Tooyama [Japon] ; P. L. Mcgeer [Canada] ; E. G. Mcgeer [Canada] ; K. Hirayama [Japon]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1994-04-01.
Abstract
Abstract: Immunohistochemistry using both a newly developed polyclonal, and a commercially available monoclonal, anti-insulin receptor antibody was done on the midbrain from cases of idiopathic Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, vascular parkinsonism and non-neurological controls. Both antibodies gave indentical patterns of neuronal staining. The neurons of the oculomotor nucleus were immunopositive in all the brains. However, the neurons in the pars compacta of the substantia nigra, paranigral nucleus, parabrachial pigmental nucleus, tegmental pedunculopontine nucleus, supratrocheal nucleus, cuneiform nucleus, subcuneiform nucleus and lemniscus medialis, which were positive in other diseases and in non-neurological controls, were not stained by these antibodies in PD brains. These results suggest that, in PD, a dysfunction of the insulin/insulin receptor system may precede death of the dopaminergic neurons.
Url:
DOI: 10.1007/BF00313602
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002341
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :002341
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001B69
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004999
Links to Exploration step
ISTEX:AF33094A95047EC5720FC060ED89C0C899006AAALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease</title><author><name sortKey="Moroo, I" sort="Moroo, I" uniqKey="Moroo I" first="I." last="Moroo">I. Moroo</name></author><author><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name></author><author><name sortKey="Makino, H" sort="Makino, H" uniqKey="Makino H" first="H." last="Makino">H. Makino</name></author><author><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name></author><author><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name></author><author><name sortKey="Hirayama, K" sort="Hirayama, K" uniqKey="Hirayama K" first="K." last="Hirayama">K. Hirayama</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AF33094A95047EC5720FC060ED89C0C899006AAA</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1007/BF00313602</idno><idno type="url">https://api-v5.istex.fr/document/AF33094A95047EC5720FC060ED89C0C899006AAA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002341</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002341</idno><idno type="wicri:Area/Istex/Curation">002341</idno><idno type="wicri:Area/Istex/Checkpoint">001B69</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B69</idno><idno type="wicri:doubleKey">0001-6322:1994:Moroo I:loss:of:insulin</idno><idno type="wicri:Area/Main/Merge">004999</idno><idno type="wicri:Area/Main/Curation">004242</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease</title><author><name sortKey="Moroo, I" sort="Moroo, I" uniqKey="Moroo I" first="I." last="Moroo">I. Moroo</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Makino, H" sort="Makino, H" uniqKey="Makino H" first="H." last="Makino">H. Makino</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Second Division of Internal Medicine, School of Medicine, Chiba University, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Molecular Neurobiology, Shiga University of Medical Science, Otsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, and the Neurodegenerative Diseases Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, and the Neurodegenerative Diseases Centre, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Hirayama, K" sort="Hirayama, K" uniqKey="Hirayama K" first="K." last="Hirayama">K. Hirayama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, 260, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1994-04-01">1994-04-01</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="343">343</biblScope><biblScope unit="page" to="348">348</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Immunohistochemistry using both a newly developed polyclonal, and a commercially available monoclonal, anti-insulin receptor antibody was done on the midbrain from cases of idiopathic Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, vascular parkinsonism and non-neurological controls. Both antibodies gave indentical patterns of neuronal staining. The neurons of the oculomotor nucleus were immunopositive in all the brains. However, the neurons in the pars compacta of the substantia nigra, paranigral nucleus, parabrachial pigmental nucleus, tegmental pedunculopontine nucleus, supratrocheal nucleus, cuneiform nucleus, subcuneiform nucleus and lemniscus medialis, which were positive in other diseases and in non-neurological controls, were not stained by these antibodies in PD brains. These results suggest that, in PD, a dysfunction of the insulin/insulin receptor system may precede death of the dopaminergic neurons.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004242 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004242 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:AF33094A95047EC5720FC060ED89C0C899006AAA
|texte= Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |