ParkinsonCanadaV1, Main, Curation, bibRecord, 003825

Etiology of Parkinson's disease

Identifieur interne : 003825 ( Main/Curation ); précédent : 003824; suivant : 003826

Etiology of Parkinson's disease

Auteurs : A. J. Stoessl [Canada]

Source :

Canadian journal of neurological sciences [ 0317-1671 ] ; 1999.

RBID : Pascal:99-0456202

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Génétique, Etiologie, Homme, Facteur milieu, Toxine.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Aging (physiology), Apoptosis (physiology), Environmental factor, Etiology, Free Radicals, Genetics, Human, Humans, Immune System Diseases (complications), Incidence, Infection (complications), Mitochondria (physiology), Nerve Growth Factors (physiology), Parkinson Disease (epidemiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson disease, Prevalence, Toxin.
MESH :
- chemical , physiology : Nerve Growth Factors.
- chemical : Free Radicals.
- complications : Immune System Diseases, Infection.
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- physiology : Aging, Apoptosis, Mitochondria.
- Humans, Incidence, Prevalence.

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Links to Exploration step

Pascal:99-0456202

Le document en format XML

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<author><name sortKey="Stoessl, A J" sort="Stoessl, A J" uniqKey="Stoessl A" first="A J" last="Stoessl">A J Stoessl</name>
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<series><title level="j">The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</title>
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<term>Incidence</term>
<term>Infection (complications)</term>
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<term>Parkinson Disease (genetics)</term>
<term>Prevalence</term>
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<front><div type="abstract" xml:lang="en">Controversy over the etiology and pathogenesis of Parkinson's disease (PD) has continued for many years and while the details have changed, the uncertainty persists. Although heritability was most emphatically refuted a decade ago by many investigators, recent progress firmly indicates that genetic factors at least play a role, although probably to a variable degree from one individual to another. Evidence for a variety of other etiological factors is amassed from epidemiological studies, animal models, molecular and cellular biology. Genetic factors, infectious and immunological abnormalities, the effects of ageing, toxins (endogenous as well as exogenous) and other environmental factors may all contribute to the development of PD. Loss of nigral dopaminergic neurons may be mediated by varying combinations of oxidative free radical toxicity, impaired mitochondrial function, "weak excitotoxicity" and abnormal handling of cytoskeletal proteins, all of which may shift the balance regulating apoptotic cell death.</div>
</front>
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{{Explor lien
   |wiki=    Wicri/Canada
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   |clé=     Pascal:99-0456202
   |texte=   Etiology of Parkinson's disease
}}

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Etiology of Parkinson's disease

Etiology of Parkinson's disease

Source :

Descripteurs français

English descriptors

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri