Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain
Identifieur interne : 003577 ( Main/Curation ); précédent : 003576; suivant : 003578Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain
Auteurs : J. Woulfe [Canada] ; H. Hoogendoorn [Canada] ; M. Tarnopolsky [Canada] ; D. G. Munoz [Canada, Espagne]Source :
- Neurology [ 0028-3878 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (immunology), Brain (pathology), Case study, Cross reaction, Enzyme-Linked Immunosorbent Assay, Epstein Barr virus, Exploration, Herpesvirus 4, Human (immunology), Human, Humans, Immunoblotting, Immunohistochemistry, Lewy Body Disease (pathology), Monoclonal antibody, Nerve Tissue Proteins (immunology), Parkinson Disease (immunology), Parkinson Disease (pathology), Parkinson disease, Synucleins, alpha-Synuclein.
- MESH :
- chemical , immunology : Antibodies, Monoclonal, Nerve Tissue Proteins.
- immunology : Herpesvirus 4, Human, Parkinson Disease.
- pathology : Brain, Lewy Body Disease, Parkinson Disease.
- Enzyme-Linked Immunosorbent Assay, Humans, Immunoblotting, Immunohistochemistry, Synucleins, alpha-Synuclein.
Abstract
Article abstract-Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and α-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.
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Pascal:01-0010818Le document en format XML
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<front><div type="abstract" xml:lang="en">Article abstract-Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and α-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.</div>
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<front><div type="abstract" xml:lang="en">Article abstract-Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with α-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and α-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.</div>
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<author><name sortKey="Hoogendoorn, H" sort="Hoogendoorn, H" uniqKey="Hoogendoorn H" first="H" last="Hoogendoorn">H. Hoogendoorn</name>
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<author><name sortKey="Tarnopolsky, M" sort="Tarnopolsky, M" uniqKey="Tarnopolsky M" first="M" last="Tarnopolsky">M. Tarnopolsky</name>
</author>
<author><name sortKey="Mu Oz, D G" sort="Mu Oz, D G" uniqKey="Mu Oz D" first="D G" last="Mu Oz">D G Mu Oz</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:11087792</idno>
<idno type="pmid">11087792</idno>
<idno type="wicri:Area/PubMed/Corpus">001606</idno>
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<idno type="wicri:doubleKey">0028-3878:2000:Woulfe J:monoclonal:antibodies:against</idno>
<idno type="wicri:Area/Main/Merge">003874</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain.</title>
<author><name sortKey="Woulfe, J" sort="Woulfe, J" uniqKey="Woulfe J" first="J" last="Woulfe">J. Woulfe</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. jwoulfe@ottawahospital.on.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pathology and Molecular Medicine, McMaster University, Hamilton</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoogendoorn, H" sort="Hoogendoorn, H" uniqKey="Hoogendoorn H" first="H" last="Hoogendoorn">H. Hoogendoorn</name>
</author>
<author><name sortKey="Tarnopolsky, M" sort="Tarnopolsky, M" uniqKey="Tarnopolsky M" first="M" last="Tarnopolsky">M. Tarnopolsky</name>
</author>
<author><name sortKey="Mu Oz, D G" sort="Mu Oz, D G" uniqKey="Mu Oz D" first="D G" last="Mu Oz">D G Mu Oz</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (immunology)</term>
<term>Brain (pathology)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Herpesvirus 4, Human (immunology)</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Immunohistochemistry</term>
<term>Lewy Body Disease (pathology)</term>
<term>Nerve Tissue Proteins (immunology)</term>
<term>Parkinson Disease (immunology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Synucleins</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Nerve Tissue Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Herpesvirus 4, Human</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Immunohistochemistry</term>
<term>Synucleins</term>
<term>alpha-Synuclein</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with alpha-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and alpha-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.</div>
</front>
</TEI>
</PubMed>
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