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Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

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Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

Auteurs : Erwan Bezard [France] ; Christian E. Gross [France] ; Jonathan M. Brotchie [Canada]

Source :

Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2003.

RBID : Pascal:04-0275228

Descripteurs français

Pascal (Inist)
- Compensation, Dopamine, Dégénérescence, Neurone dopaminergique, Déplétion, Corps strié, Plasticité, Article synthèse, Parkinson maladie.

English descriptors

KwdEn :
- Compensation, Corpus striatum, Degeneration, Depletion, Dopamine, Dopaminergic neuron, Parkinson disease, Plasticity, Review.

Abstract

The symptoms of Parkinson's disease (PD) appear only after substantial degeneration of the dopaminergic neuron system (e.g. an 80% depletion of striatal dopamine) - that is, there is a substantive presymptomatic period of the disease. It is widely believed that dopamine-related compensatory mechanisms are responsible for delaying the appearance of symptoms. Recent advances in understanding the presymptomatic phase of PD have increased our understanding of these dopamine-related compensatory mechanisms and have highlighted the role of non-dopamine-mediated mechanisms both within and outside the basal ganglia. This increased knowledge of plasticity within cortical-basal-ganglia-thalamocortical circuitry as dopaminergic neuron degeneration progresses has implications for understanding plasticity in neural circuits generally and, more specifically, for developing novel therapeutics or presymptomatic diagnostics for PD.

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Le document en format XML

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<term>Corpus striatum</term>
<term>Degeneration</term>
<term>Depletion</term>
<term>Dopamine</term>
<term>Dopaminergic neuron</term>
<term>Parkinson disease</term>
<term>Plasticity</term>
<term>Review</term>
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<term>Déplétion</term>
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<term>Article synthèse</term>
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<front><div type="abstract" xml:lang="en">The symptoms of Parkinson's disease (PD) appear only after substantial degeneration of the dopaminergic neuron system (e.g. an 80% depletion of striatal dopamine) - that is, there is a substantive presymptomatic period of the disease. It is widely believed that dopamine-related compensatory mechanisms are responsible for delaying the appearance of symptoms. Recent advances in understanding the presymptomatic phase of PD have increased our understanding of these dopamine-related compensatory mechanisms and have highlighted the role of non-dopamine-mediated mechanisms both within and outside the basal ganglia. This increased knowledge of plasticity within cortical-basal-ganglia-thalamocortical circuitry as dopaminergic neuron degeneration progresses has implications for understanding plasticity in neural circuits generally and, more specifically, for developing novel therapeutics or presymptomatic diagnostics for PD.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri