ParkinsonCanadaV1, Main, Curation, bibRecord, 002692

Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons

Identifieur interne : 002692 ( Main/Curation ); précédent : 002691; suivant : 002693

Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons

Auteurs : Andrew S. Lim [Canada] ; Andres M. Lozano [Canada] ; Elena Moro [Canada] ; Clement Hamani [Canada] ; William D. Hutchison [Canada] ; Jonathan O. Dostrovsky [Canada] ; Anthony E. Lang [Canada] ; Richard A. Wennberg [Canada] ; Brian J. Murray [Canada]

Source :

Sleep : (New York, NY) [ 0161-8105 ] ; 2007.

RBID : Pascal:07-0340762

Descripteurs français

Pascal (Inist)
- Caractérisation, Sommeil paradoxal, Pointe pontogéniculooccipitale, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Characterization, Electric Stimulation (instrumentation), Geniculate Bodies (pathology), Geniculate Bodies (physiopathology), Geniculate Bodies (surgery), Human, Humans, Magnetic Resonance Imaging, Male, Occipital Lobe (pathology), Occipital Lobe (physiopathology), Occipital Lobe (surgery), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Pons (pathology), Pons (physiopathology), Pons (surgery), Pontogeniculooccipital spike, Rapid eye movement sleep, Sleep, REM (physiology).
MESH :
- instrumentation : Electric Stimulation.
- pathology : Geniculate Bodies, Occipital Lobe, Pons.
- physiology : Sleep, REM.
- physiopathology : Geniculate Bodies, Occipital Lobe, Parkinson Disease, Pons.
- surgery : Geniculate Bodies, Occipital Lobe, Pons.
- therapy : Parkinson Disease.
- Aged, Humans, Magnetic Resonance Imaging, Male.

Abstract

Study Objectives: Ponto-geniculo-occipital (PGO) waves are phasic pontine, lateral geniculate, and cortical field potentials occurring during and before REM sleep that are proposed to mediate a wide variety of sleep related neural processes. We sought to identify and characterize human PGO waves. Design: We recorded simultaneously from intrapontine depth electrodes and scalp electrodes in a human subject across sleep states. Setting: Tertiary care neurological and neurosurgical referral center. Patients or Participants: We studied a patient involved in a study of the clinical effects of unilateral pedunculopontine nucleus (PPN) stimulation on Parkinson disease (PD). Interventions: No interventions. Measurements and Results: We recorded phasic potentials from the human pons occurring during and before REM sleep with a morphology, temporal distribution, and localization similar to those of PGO waves in other mammals. The source of these potentials was localized to a circumscribed region of the pontomesencephalic tegmentum. These potentials were only incompletely associated with eye movements. They were followed by characteristic cortical potentials with a latency of 20-140 msec. Conclusions: We conclude that PGO waves are a feature of human REM sleep, that they are generated or propagated in the pontomesencephalic tegmentum, that they are only partially associated with eye movements, and that they are associated with characteristic changes in cortical activity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978372

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Characterization</term>
<term>Electric Stimulation (instrumentation)</term>
<term>Geniculate Bodies (pathology)</term>
<term>Geniculate Bodies (physiopathology)</term>
<term>Geniculate Bodies (surgery)</term>
<term>Human</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Occipital Lobe (pathology)</term>
<term>Occipital Lobe (physiopathology)</term>
<term>Occipital Lobe (surgery)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Pons (pathology)</term>
<term>Pons (physiopathology)</term>
<term>Pons (surgery)</term>
<term>Pontogeniculooccipital spike</term>
<term>Rapid eye movement sleep</term>
<term>Sleep, REM (physiology)</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Study Objectives: Ponto-geniculo-occipital (PGO) waves are phasic pontine, lateral geniculate, and cortical field potentials occurring during and before REM sleep that are proposed to mediate a wide variety of sleep related neural processes. We sought to identify and characterize human PGO waves. Design: We recorded simultaneously from intrapontine depth electrodes and scalp electrodes in a human subject across sleep states. Setting: Tertiary care neurological and neurosurgical referral center. Patients or Participants: We studied a patient involved in a study of the clinical effects of unilateral pedunculopontine nucleus (PPN) stimulation on Parkinson disease (PD). Interventions: No interventions. Measurements and Results: We recorded phasic potentials from the human pons occurring during and before REM sleep with a morphology, temporal distribution, and localization similar to those of PGO waves in other mammals. The source of these potentials was localized to a circumscribed region of the pontomesencephalic tegmentum. These potentials were only incompletely associated with eye movements. They were followed by characteristic cortical potentials with a latency of 20-140 msec. Conclusions: We conclude that PGO waves are a feature of human REM sleep, that they are generated or propagated in the pontomesencephalic tegmentum, that they are only partially associated with eye movements, and that they are associated with characteristic changes in cortical activity.</div>
</front>
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<front><div type="abstract" xml:lang="en">Study Objectives: Ponto-geniculo-occipital (PGO) waves are phasic pontine, lateral geniculate, and cortical field potentials occurring during and before REM sleep that are proposed to mediate a wide variety of sleep related neural processes. We sought to identify and characterize human PGO waves. Design: We recorded simultaneously from intrapontine depth electrodes and scalp electrodes in a human subject across sleep states. Setting: Tertiary care neurological and neurosurgical referral center. Patients or Participants: We studied a patient involved in a study of the clinical effects of unilateral pedunculopontine nucleus (PPN) stimulation on Parkinson disease (PD). Interventions: No interventions. Measurements and Results: We recorded phasic potentials from the human pons occurring during and before REM sleep with a morphology, temporal distribution, and localization similar to those of PGO waves in other mammals. The source of these potentials was localized to a circumscribed region of the pontomesencephalic tegmentum. These potentials were only incompletely associated with eye movements. They were followed by characteristic cortical potentials with a latency of 20-140 msec. Conclusions: We conclude that PGO waves are a feature of human REM sleep, that they are generated or propagated in the pontomesencephalic tegmentum, that they are only partially associated with eye movements, and that they are associated with characteristic changes in cortical activity.</div>
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<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name>
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<affiliation wicri:level="4"><nlm:aff id="aff3">Department of Physiology, University of Toronto, Ontario, Canada</nlm:aff>
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<wicri:regionArea>Department of Physiology, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name>
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<wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<affiliation wicri:level="4"><nlm:aff id="aff3">Department of Physiology, University of Toronto, Ontario, Canada</nlm:aff>
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
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</author>
<author><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A." last="Wennberg">Richard A. Wennberg</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
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<author><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J." last="Murray">Brian J. Murray</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of REM-Sleep Associated Ponto-Geniculo-Occipital Waves in the Human Pons</title>
<author><name sortKey="Lim, Andrew S" sort="Lim, Andrew S" uniqKey="Lim A" first="Andrew S." last="Lim">Andrew S. Lim</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff3">Department of Physiology, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Physiology, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name>
<affiliation wicri:level="4"><nlm:aff id="aff2">Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff3">Department of Physiology, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Physiology, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A." last="Wennberg">Richard A. Wennberg</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J." last="Murray">Brian J. Murray</name>
<affiliation wicri:level="4"><nlm:aff id="aff1">Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Electric Stimulation (instrumentation)</term>
<term>Geniculate Bodies (pathology)</term>
<term>Geniculate Bodies (physiopathology)</term>
<term>Geniculate Bodies (surgery)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Occipital Lobe (pathology)</term>
<term>Occipital Lobe (physiopathology)</term>
<term>Occipital Lobe (surgery)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Pons (pathology)</term>
<term>Pons (physiopathology)</term>
<term>Pons (surgery)</term>
<term>Sleep, REM (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Geniculate Bodies</term>
<term>Occipital Lobe</term>
<term>Pons</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep, REM</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Geniculate Bodies</term>
<term>Occipital Lobe</term>
<term>Parkinson Disease</term>
<term>Pons</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Geniculate Bodies</term>
<term>Occipital Lobe</term>
<term>Pons</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Ponto-geniculo-occipital (PGO) waves are phasic pontine, lateral geniculate, and cortical field potentials occurring during and before REM sleep that are proposed to mediate a wide variety of sleep related neural processes. We sought to identify and characterize human PGO waves.</p>
</sec>
<sec><title>Design:</title>
<p>We recorded simultaneously from intrapontine depth electrodes and scalp electrodes in a human subject across sleep states.</p>
</sec>
<sec><title>Setting:</title>
<p>Tertiary care neurological and neurosurgical referral center.</p>
</sec>
<sec><title>Patients or Participants:</title>
<p>We studied a patient involved in a study of the clinical effects of unilateral pedunculopontine nucleus (PPN) stimulation on Parkinson disease (PD).</p>
</sec>
<sec><title>Interventions:</title>
<p>No interventions.</p>
</sec>
<sec><title>Measurements and Results:</title>
<p>We recorded phasic potentials from the human pons occurring during and before REM sleep with a morphology, temporal distribution, and localization similar to those of PGO waves in other mammals. The source of these potentials was localized to a circumscribed region of the pontomesencephalic tegmentum. These potentials were only incompletely associated with eye movements. They were followed by characteristic cortical potentials with a latency of 20–140 msec.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We conclude that PGO waves are a feature of human REM sleep, that they are generated or propagated in the pontomesencephalic tegmentum, that they are only partially associated with eye movements, and that they are associated with characteristic changes in cortical activity.</p>
</sec>
<sec><title>Citation:</title>
<p>Lim AS; Lozano AM; Moro E et al. Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons. <italic>SLEEP</italic>
 2007;30(7):823-827.</p>
</sec>
</div>
</front>
</TEI>
</PMC>
</double>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons

Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons

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