ParkinsonCanadaV1, Main, Curation, bibRecord, 002378

Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

Identifieur interne : 002378 ( Main/Curation ); précédent : 002377; suivant : 002379

Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

Auteurs : Jasper E. Visser [Pays-Bas, Suisse] ; John H. J. Allum [Suisse] ; Mark G. Carpenter [Suisse, Canada] ; Rianne A. Esselink [Pays-Bas] ; Johannes D. Speelman [Pays-Bas] ; George F. Borm [Pays-Bas] ; Bastiaan R. Bloem [Pays-Bas]

Source :

Journal of neurology [ 0340-5354 ] ; 2008.

RBID : Pascal:08-0276247

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Noyau sousthalamique, Lévodopa, Instabilité, Encéphale, Chirurgie, Posturographie.
Wicri :
- topic : Chirurgie.

English descriptors

KwdEn :
- Encephalon, Instability, Levodopa, Nervous system diseases, Parkinson disease, Posturography, Subthalamic nucleus, Surgery.

Abstract

We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa-resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.

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Le document en format XML

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<series><title level="j" type="main">Journal of neurology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Encephalon</term>
<term>Instability</term>
<term>Levodopa</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Posturography</term>
<term>Subthalamic nucleus</term>
<term>Surgery</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Noyau sousthalamique</term>
<term>Lévodopa</term>
<term>Instabilité</term>
<term>Encéphale</term>
<term>Chirurgie</term>
<term>Posturographie</term>
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<front><div type="abstract" xml:lang="en">We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathreshold dose of levodopa, both with stimulators turned on and off. Patients with stimulators turned off were more unstable than controls following backward directed perturbations. Overall, patients' instability did not improve with STN stimulation, and considerable inter-individual variability was noted. Of note, marked levodopa-resistant axial motor symptoms before surgery correlated with an adverse treatment effect. We conclude that STN stimulation does not alleviate levodopa-resistant postural instability in Parkinson's disease.</div>
</front>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri