Improving adeno‐associated vector yield in high density insect cell cultures
Identifieur interne : 001C11 ( Main/Curation ); précédent : 001C10; suivant : 001C12Improving adeno‐associated vector yield in high density insect cell cultures
Auteurs : Jimmy A. Mena [Canada] ; Marc G. Aucoin [Canada] ; Johnny Montes [Canada] ; Parminder S. Chahal [Canada] ; Amine A. Kamen [Canada]Source :
- The Journal of Gene Medicine [ 1099-498X ] ; 2010-02.
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Abstract
Recombinant adeno‐associated virus (rAAV) are the most promising vectors for gene therapy. However, large‐scale rAAV production remains a challenge for the translation of rAAV‐based therapeutic strategies to the clinic. The baculovirus expression vector system (BEVS) has been engineered to produce high rAAV titers in serum‐free suspension cultures of insect cells.
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DOI: 10.1002/jgm.1420
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<front><div type="abstract">Recombinant adeno‐associated virus (rAAV) are the most promising vectors for gene therapy. However, large‐scale rAAV production remains a challenge for the translation of rAAV‐based therapeutic strategies to the clinic. The baculovirus expression vector system (BEVS) has been engineered to produce high rAAV titers in serum‐free suspension cultures of insect cells.</div>
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