ParkinsonCanadaV1, Main, Curation, bibRecord, 001883

Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder

Identifieur interne : 001883 ( Main/Curation ); précédent : 001882; suivant : 001884

Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder

Auteurs : Mélanie Vendette [Canada] ; Jean-François Gagnon [Canada] ; Jean-Paul Soucy [Canada] ; Nadia Gosselin [Canada] ; Ronald B. Postuma [Canada] ; Maria Tuineag [Canada] ; Isabelle Godin [Canada] ; Jacques Montplaisir [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-08-01.

RBID : ISTEX:3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12

Descripteurs français

Pascal (Inist)
- Comportement, Débit sanguin régional, Démence à corps de Lewy, Encéphale, Maladie de Parkinson, Pathologie du système nerveux, Sommeil paradoxal, Tomoscintigraphie émission monophotonique.

English descriptors

KwdEn :
- Behavior, Encephalon, Lewy body dementia, Nervous system diseases, Parkinson disease, Parkinson's disease, Rapid eye movement sleep, Regional blood flow, Single photon emission tomography, markers of neurodegeneration, rapid eye movement sleep behavior disorder, single‐photon emission computerized tomography (regional cerebral blood flow).

Abstract

Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society

Url:

https://api-v5.istex.fr/document/3236139A4D2A2CE02F01B7BBB994D6F1E84CAA12/fulltext/pdf

DOI: 10.1002/mds.23721

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Le document en format XML

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<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<term>Encephalon</term>
<term>Lewy body dementia</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Rapid eye movement sleep</term>
<term>Regional blood flow</term>
<term>Single photon emission tomography</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Encéphale</term>
<term>Sommeil paradoxal</term>
<term>Comportement</term>
<term>Tomoscintigraphie émission monophotonique</term>
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<front><div type="abstract" xml:lang="en">Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single-photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration.</div>
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<author><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
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</affiliation>
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<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
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<wicri:regionArea>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré‐Cœur de Montréal, 5400 boul. Gouin Ouest, Montréal, Québec</wicri:regionArea>
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<term>Parkinson's disease</term>
<term>markers of neurodegeneration</term>
<term>rapid eye movement sleep behavior disorder</term>
<term>single‐photon emission computerized tomography (regional cerebral blood flow)</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Potential early markers of neurodegeneration such as subtle motor signs, reduced color discrimination, olfactory impairment, and brain perfusion abnormalities have been reported in idiopathic rapid eye movement sleep behavior disorder, a risk factor for Parkinson's disease and Lewy body dementia. The aim of this study was to reproduce observations of regional cerebral blood flow abnormalities in a larger independent sample of patients and to explore correlations between regional cerebral blood flow and markers of neurodegeneration. Twenty patients with idiopathic rapid eye movement sleep behavior disorder and 20 healthy controls were studied by single‐photon emission computerized tomography. Motor examination, color discrimination, and olfactory identification were examined. Patients with rapid eye movement sleep behavior disorder showed decreased regional cerebral blood flow in the frontal cortex and in medial parietal areas and increased regional cerebral blood flow in subcortical regions including the bilateral pons, putamen, and hippocampus. In rapid eye movement sleep behavior disorder, brain perfusion in the frontal cortex and occipital areas was associated with poorer performance in the color discrimination test. Moreover, a relationship between loss of olfactory discrimination and regional cerebral blood flow reduction in the bilateral anterior parahippocampal gyrus, a region known to be involved in olfactory functions, was found. This study provides further evidence of regional cerebral blood flow abnormalities in rapid eye movement sleep behavior disorder that are similar to those seen in Parkinson's disease and Lewy body dementia. Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration. © 2011 Movement Disorder Society</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder

Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder

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