Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study
Identifieur interne : 001035 ( Main/Curation ); précédent : 001034; suivant : 001036Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study
Auteurs : HONGLIU DING [Royaume-Uni] ; Kaltra Dhima [Royaume-Uni, États-Unis] ; Kaitlin C. Lockhart [Royaume-Uni, États-Unis] ; Joseph J. Locascio [États-Unis] ; Ashley N. Hoesing [Royaume-Uni, États-Unis] ; Karen Duong [Royaume-Uni, États-Unis] ; Ana Trisini-Lipsanopoulos [Royaume-Uni, États-Unis] ; Michael T. Hayes [États-Unis] ; U. Shivraj Sohur [États-Unis] ; Anne-Marie Wills [États-Unis] ; Brit Mollenhauer [États-Unis, Allemagne] ; Alice W. Flaherty [États-Unis] ; Albert Y. Hung [États-Unis] ; Nicte Mejia [États-Unis] ; Vikram Khurana [États-Unis] ; Stephen N. Gomperts [États-Unis] ; Dennis J. Selkoe [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Michael G. Schlossmacher [États-Unis, Canada] ; Bradley T. Hyman [États-Unis] ; Lewis R. Sudarsky [États-Unis] ; John H. Growdon [États-Unis] ; Clemens R. Scherzer [Royaume-Uni, États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD). Methods: We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D3 and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study. Results: Plasma levels of 25-hydroxy-vitamin D3 were associated with PD in both univariate and multivariate analyses with p values = 0.0034 and 0.047, respectively. Total 25-hydroxy-vitamin D levels, the traditional composite measure of endogenous and exogenous vitamin D, were deficient in 17.6% of patients with PD compared with 9.3% of controls. Low 25-hydroxy-vitamin D3 as well as total 25-hydroxy-vitamin D levels were correlated with higher total Unified Parkinson's Disease Rating Scale scores at baseline and during follow-up. Conclusions: Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.
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<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name>
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<publicationStmt><idno type="wicri:source">INIST</idno>
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<idno type="wicri:doubleKey">0028-3878:2013:Hongliu Ding:unrecognized:vitamin:d</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Unrecognized vitamin D<sub>3</sub>
deficiency is common in Parkinson disease: Harvard Biomarker Study</title>
<author><name sortKey="Hongliu Ding" sort="Hongliu Ding" uniqKey="Hongliu Ding" last="Hongliu Ding">HONGLIU DING</name>
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<author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name>
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<author><name sortKey="Lockhart, Kaitlin C" sort="Lockhart, Kaitlin C" uniqKey="Lockhart K" first="Kaitlin C." last="Lockhart">Kaitlin C. Lockhart</name>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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<country>États-Unis</country>
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<author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name>
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<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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<country>États-Unis</country>
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<author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurogenomics Laboratory, Harvard Medical School and Brigham & Women's Hospital</s1>
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</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Brigham and Women's Hospital</s1>
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<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U." last="Shivraj Sohur">U. Shivraj Sohur</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
<s2>Boston</s2>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
<s2>Boston</s2>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Paracelsus-Elena-Klinik</s1>
<s2>Kassel</s2>
<s3>DEU</s3>
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</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Kassel</region>
<settlement type="city">Cassel (Hesse)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Brigham and Women's Hospital</s1>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mejia, Nicte" sort="Mejia, Nicte" uniqKey="Mejia N" first="Nicte" last="Mejia">Nicte Mejia</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
<s2>Boston</s2>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Khurana, Vikram" sort="Khurana, Vikram" uniqKey="Khurana V" first="Vikram" last="Khurana">Vikram Khurana</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
<s2>Boston</s2>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gomperts, Stephen N" sort="Gomperts, Stephen N" uniqKey="Gomperts S" first="Stephen N." last="Gomperts">Stephen N. Gomperts</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name>
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<sZ>20 aut.</sZ>
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<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Brigham and Women's Hospital</s1>
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<sZ>8 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name>
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<sZ>2 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
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<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name>
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<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
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<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Neurology, the Ottawa Hospital, University of Ottawa</s1>
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<country>Canada</country>
<wicri:noRegion>Division of Neurology, the Ottawa Hospital, University of Ottawa</wicri:noRegion>
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</author>
<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
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<region type="state">Massachusetts</region>
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<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, MA</s2>
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<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
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<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
<s2>Boston</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
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<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
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<sZ>10 aut.</sZ>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
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<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurogenomics Laboratory, Harvard Medical School and Brigham & Women's Hospital</s1>
<s2>Cambridge</s2>
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<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Biomarkers Program, Harvard NeuroDiscovery Center</s1>
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<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurology, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
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<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
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</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colecalciferol</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Vitamin deficiency</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Carence vitaminique</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Colécalciférol</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D<sub>3</sub>
, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD). Methods: We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D<sub>3</sub>
and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study. Results: Plasma levels of 25-hydroxy-vitamin D<sub>3</sub>
were associated with PD in both univariate and multivariate analyses with p values = 0.0034 and 0.047, respectively. Total 25-hydroxy-vitamin D levels, the traditional composite measure of endogenous and exogenous vitamin D, were deficient in 17.6% of patients with PD compared with 9.3% of controls. Low 25-hydroxy-vitamin D<sub>3</sub>
as well as total 25-hydroxy-vitamin D levels were correlated with higher total Unified Parkinson's Disease Rating Scale scores at baseline and during follow-up. Conclusions: Our study reveals an association between 25-hydroxy-vitamin D<sub>3</sub>
and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.</div>
</front>
</TEI>
</record>
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