Deep Brain Stimulation Target Selection for Parkinson's Disease.
Identifieur interne : 000102 ( Main/Curation ); précédent : 000101; suivant : 000103Deep Brain Stimulation Target Selection for Parkinson's Disease.
Auteurs : Christopher R. Honey ; Clement Hamani ; Suneil K. Kalia [Canada] ; Tejas Sankar ; Marina Picillo [Canada] ; Renato P. Munhoz [Canada] ; Alfonso Fasano [Canada] ; Michel Panisset [Canada]Source :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Brain.
- methods : Deep Brain Stimulation.
- physiology : Brain.
- therapy : Parkinson Disease.
- Humans.
Abstract
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to discuss three main questions on target selection for deep brain stimulation (DBS) of patients with Parkinson's disease (PD). First, is the subthalamic nucleus (STN) or the globus pallidus internus (GPi) the ideal target? In summary, both targets are equally effective in improving the motor symptoms of PD. STN allows a greater medications reduction, while GPi exerts a direct antidyskinetic effect. Second, are there further potential targets? Ventral intermediate nucleus DBS has significant long-term benefit for tremor control but insufficiently addresses other motor features of PD. DBS in the posterior subthalamic area also reduces tremor. The pedunculopontine nucleus remains an investigational target. Third, should DBS for PD be performed unilaterally, bilaterally or staged? Unilateral STN DBS can be proposed to asymmetric patients. There is no evidence that a staged bilateral approach reduces the incidence of DBS-related adverse events.
DOI: 10.1017/cjn.2016.22
PubMed: 26976064
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Christopher R. Honey<affiliation><nlm:affiliation>1Division of Neurosurgery,University of British Columbia,Vancouver,British Columbia.</nlm:affiliation>
<wicri:noCountry code="subField">British Columbia</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>2Research Imaging Centre,Centre for Addiction and Mental Health,Toronto.</nlm:affiliation>
<wicri:noCountry code="subField">Toronto</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>5Division of Neurosurgery,Walter C. MacKenzie Health Sciences Centre,University of Alberta,Edmonton,Alberta.</nlm:affiliation>
<wicri:noCountry code="subField">Alberta</wicri:noCountry>
</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en">During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to discuss three main questions on target selection for deep brain stimulation (DBS) of patients with Parkinson's disease (PD). First, is the subthalamic nucleus (STN) or the globus pallidus internus (GPi) the ideal target? In summary, both targets are equally effective in improving the motor symptoms of PD. STN allows a greater medications reduction, while GPi exerts a direct antidyskinetic effect. Second, are there further potential targets? Ventral intermediate nucleus DBS has significant long-term benefit for tremor control but insufficiently addresses other motor features of PD. DBS in the posterior subthalamic area also reduces tremor. The pedunculopontine nucleus remains an investigational target. Third, should DBS for PD be performed unilaterally, bilaterally or staged? Unilateral STN DBS can be proposed to asymmetric patients. There is no evidence that a staged bilateral approach reduces the incidence of DBS-related adverse events.</div>
</front>
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