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Carbon monoxide, carbon disulfide, lead and cadmium — Four examples of occupational toxic agents linked to cardiovascular disease

Identifieur interne : 002385 ( Istex/Curation ); précédent : 002384; suivant : 002386

Carbon monoxide, carbon disulfide, lead and cadmium — Four examples of occupational toxic agents linked to cardiovascular disease

Auteurs : J. Wojtczak-Jaroszowa [Canada] ; S. Kubow [Canada]

Source :

RBID : ISTEX:141FD699E9ADB54E0A5504406C82590CC1E358F2

Abstract

A variety of industrial agents to which large segments of the population are exposed have been linked to the development of cardiovascular disease. These toxic agents, which include carbon monoxide, carbon disulphide, lead, and cadmium, are produced by a wide variety of industrial processes and so are ubiquitous in the modern industrial environment. Although the mechanisms by which such toxins may contribute to cardiovascular disease are not well defined, there are at least four possible theories that have received clinical and experimental support. The postulated mechanisms by which such toxins may play a role in vascular disease are: (1) an increase in blood pressure; (2) an increase in the levels of blood cholesterol and/or an induction of lipid accumulation in vessel walls; (3) an induction of a lipid peroxidation process thereby increasing the tendency of blood clotting; and (4) a promotion of a mutation in the arterial cell wall.

Url:
DOI: 10.1016/0306-9877(89)90101-1

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ISTEX:141FD699E9ADB54E0A5504406C82590CC1E358F2

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