l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys
Identifieur interne : 001D35 ( Istex/Curation ); précédent : 001D34; suivant : 001D36l-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys
Auteurs : Jean-Jacques Soghomonian [Canada] ; Sophie Pedneault [Canada] ; Pierre J. Blanchet [Canada] ; Martin Goulet [Canada] ; Thérèse Di Paolo [Canada] ; Paul J. Bédard [Canada]Source :
- Molecular Brain Research [ 0169-328X ] ; 1996.
Abstract
The effect of dopaminergic denervation, alone or followed by chronic intermittent l-DOPA administration, on the levels of mRNAs encoding for the two isoforms of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD65 and GAD67), were measured by in-situ hybridization in the caudate and putamen of macaque monkeys. When compared to control monkeys, the level of GAD67 mRNA was increased in the putamen and caudate of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. On the other hand, GAD65 mRNA labeling in MPTP-treated monkeys was not significantly different from the controls. In MPTP-treated monkeys that received l-DOPA, a significant increase in both GAD67 and GAD65 mRNA levels was measured in the putamen when compared to control or MPTP-treated monkeys. The results suggest that the dyskinetic effect of l-DOPA is paralleled by an increased GABAergic activity in the striatum.
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DOI: 10.1016/0169-328X(96)00078-2
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Quebec G1J 1Z4</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Brain Research</title><title level="j" type="abbrev">BRESM</title><idno type="ISSN">0169-328X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="237">237</biblScope><biblScope unit="page" to="240">240</biblScope></imprint><idno type="ISSN">0169-328X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-328X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of dopaminergic denervation, alone or followed by chronic intermittent l-DOPA administration, on the levels of mRNAs encoding for the two isoforms of the GABA-synthesizing enzyme, glutamate decarboxylase (GAD65 and GAD67), were measured by in-situ hybridization in the caudate and putamen of macaque monkeys. When compared to control monkeys, the level of GAD67 mRNA was increased in the putamen and caudate of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. On the other hand, GAD65 mRNA labeling in MPTP-treated monkeys was not significantly different from the controls. In MPTP-treated monkeys that received l-DOPA, a significant increase in both GAD67 and GAD65 mRNA levels was measured in the putamen when compared to control or MPTP-treated monkeys. The results suggest that the dyskinetic effect of l-DOPA is paralleled by an increased GABAergic activity in the striatum.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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