Acute paw oedema induced by local injection of adenosine A1, A2 and A3 receptor agonists
Identifieur interne : 001A78 ( Istex/Curation ); précédent : 001A77; suivant : 001A79Acute paw oedema induced by local injection of adenosine A1, A2 and A3 receptor agonists
Auteurs : Jana Sawynok [Canada] ; Allison Reid [Canada] ; Xue Jun Liu [Canada]Source :
- European Journal of Pharmacology [ 0014-2999 ] ; 1999.
Abstract
The present study used plethysmometry to examine oedema following local injection of selective adenosine A1, A2 and A3 receptor agonists and inhibitors of adenosine metabolism into the hindpaw of the rat. N6-Cyclopentyladenosine and l-N6-phenylisopropyladenosine (A1), 2-[p(2-carboxyethyl) phenethylamino]-5′-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) (A2A) and N6-benzyl-5′-N-ethylcarboxamido adenosine (N6-B-NECA) (A3) all produced an increase in paw volume (N6-B-NECA>N6-cyclopentyladenosine, l-N6-phenylisopropyladenosine>CGS21680). At the highest dose, each agent also produced a systemically mediated suppression of oedema. Oedema by N6-cyclopentyladenosine was blocked by caffeine, 8-cyclopentyl-1,3-dimethylxanthine and enprofylline. Oedema by CGS21680 was blocked by caffeine and 8-cyclopentyl-1,3-dimethylxanthine. Oedema by N6-B-NECA was blocked by enprofylline, but not by caffeine or 8-cyclopentyl-1,3-dimethylxanthine, or by systemic administration of MRS 1191. Oedema by both N6-cyclopentyladenosine and N6-B-NECA was blocked by mepyramine, ketanserin and phentolamine, but that by CGS21680 was not. The adenosine kinase inhibitor 5′-amino-5′-deoxyadenosine and the adenosine deaminase inhibitor 2′-deoxycoformycin produced only a limited increase in paw volume, and this was blocked by caffeine. This study demonstrates an acute paw oedema response following local administration of adenosine A1, A2 and A3 receptor agonists, which likely results from different mechanisms of action in each case.
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DOI: 10.1016/S0014-2999(99)00752-9
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Acute paw oedema induced by local injection of adenosine A1, A2 and A3 receptor agonists</title><author><name sortKey="Sawynok, Jana" sort="Sawynok, Jana" uniqKey="Sawynok J" first="Jana" last="Sawynok">Jana Sawynok</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sawydalu@is.dal.ca</mods:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Reid, Allison" sort="Reid, Allison" uniqKey="Reid A" first="Allison" last="Reid">Allison Reid</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xue Jun" sort="Liu, Xue Jun" uniqKey="Liu X" first="Xue Jun" last="Liu">Xue Jun Liu</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6C20190236D448967242091FB356F5B7833B6D48</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0014-2999(99)00752-9</idno><idno type="url">https://api-v5.istex.fr/document/6C20190236D448967242091FB356F5B7833B6D48/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A78</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A78</idno><idno type="wicri:Area/Istex/Curation">001A78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Acute paw oedema induced by local injection of adenosine A1, A2 and A3 receptor agonists</title><author><name sortKey="Sawynok, Jana" sort="Sawynok, Jana" uniqKey="Sawynok J" first="Jana" last="Sawynok">Jana Sawynok</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: sawydalu@is.dal.ca</mods:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Reid, Allison" sort="Reid, Allison" uniqKey="Reid A" first="Allison" last="Reid">Allison Reid</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xue Jun" sort="Liu, Xue Jun" uniqKey="Liu X" first="Xue Jun" last="Liu">Xue Jun Liu</name><affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7</mods:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Pharmacology</title><title level="j" type="abbrev">EJP</title><idno type="ISSN">0014-2999</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">386</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="253">253</biblScope><biblScope unit="page" to="261">261</biblScope></imprint><idno type="ISSN">0014-2999</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2999</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study used plethysmometry to examine oedema following local injection of selective adenosine A1, A2 and A3 receptor agonists and inhibitors of adenosine metabolism into the hindpaw of the rat. N6-Cyclopentyladenosine and l-N6-phenylisopropyladenosine (A1), 2-[p(2-carboxyethyl) phenethylamino]-5′-N-ethylcarboxamidoadenosine hydrochloride (CGS21680) (A2A) and N6-benzyl-5′-N-ethylcarboxamido adenosine (N6-B-NECA) (A3) all produced an increase in paw volume (N6-B-NECA>N6-cyclopentyladenosine, l-N6-phenylisopropyladenosine>CGS21680). At the highest dose, each agent also produced a systemically mediated suppression of oedema. Oedema by N6-cyclopentyladenosine was blocked by caffeine, 8-cyclopentyl-1,3-dimethylxanthine and enprofylline. Oedema by CGS21680 was blocked by caffeine and 8-cyclopentyl-1,3-dimethylxanthine. Oedema by N6-B-NECA was blocked by enprofylline, but not by caffeine or 8-cyclopentyl-1,3-dimethylxanthine, or by systemic administration of MRS 1191. Oedema by both N6-cyclopentyladenosine and N6-B-NECA was blocked by mepyramine, ketanserin and phentolamine, but that by CGS21680 was not. The adenosine kinase inhibitor 5′-amino-5′-deoxyadenosine and the adenosine deaminase inhibitor 2′-deoxycoformycin produced only a limited increase in paw volume, and this was blocked by caffeine. This study demonstrates an acute paw oedema response following local administration of adenosine A1, A2 and A3 receptor agonists, which likely results from different mechanisms of action in each case.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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