Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules
Identifieur interne : 001414 ( Istex/Curation ); précédent : 001413; suivant : 001415Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules
Auteurs : A. Parkinson [États-Unis] ; L. Robertson [Canada] ; Lorna Safe [États-Unis] ; S. Safe [États-Unis]Source :
- Chemico-Biological Interactions [ 0009-2797 ] ; 1980.
English descriptors
- KwdEn :
Abstract
A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 μmol · kg−1. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo[a]pyrene (B[a]P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b5 content and the relative peak intensities and spectral shifts of the reduced microsomal cytochrome P-450: CO and ethylisocyanide (EIC) binding difference spectra. The results were compared to the effects of administering phenobarbitone (PB), 3-methylcholanthrene (MC) and PB plus MC (coadministered) to the test animals. The synthetic PCB congeners used in this study included 3,4,4′,5-tetrachlorobiphenyl (TCBP-1), 2,3′,4,4′-tetrachlorobiphenyl (TCBP-2), 2,3′,4,4′,5′-pentachlorobiphenyl (PCBP-1), 2,3,4,4′,5-pentachlorobiphenyl (PCBP-2), 2,3,3′,4,4′,5-hexachlorobiphenyl (HCBP-1), 2,3,3′,4′,5,6-hexachlorobiphenyl (HCBP-2), 2,3,3′,5,5′,6-hexachlorobiphenyl (HCBP-3), 2,2′,3,5,5′,6-hexachlorobiphenyl (HCBP-4) and 2,3,3′,4,5,5′-hexachlorobiphenyl (HCBP-5) and were used to reappraise the structure-activity rules for PCBs as hepatic microsomal enzyme inducers. The results suggested that (a) PCBs which induce MC or mixed-type activity must be substituted at both para positions, at least two meta positions but not necessarily on the same phenyl ring and can also contain one ortho chloro substituent; (b) due to the considerable structural diversity of the PB-type inducers the rules for induction of this activity by PCB congeners are not readily defined.
Url:
DOI: 10.1016/0009-2797(80)90050-2
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001414
Links to Exploration step
ISTEX:1878F9681122BF28A4DFC9B2DDA158A6DD4EFF8FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules</title>
<author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name>
<affiliation wicri:level="2"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name>
<affiliation wicri:level="1"><mods:affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1 Canada</mods:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Safe, Lorna" sort="Safe, Lorna" uniqKey="Safe L" first="Lorna" last="Safe">Lorna Safe</name>
<affiliation wicri:level="1"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name>
<affiliation><mods:affiliation>To whom reprint requests should be sent.</mods:affiliation>
<wicri:noCountry code="no comma">To whom reprint requests should be sent.</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1878F9681122BF28A4DFC9B2DDA158A6DD4EFF8F</idno>
<date when="1980" year="1980">1980</date>
<idno type="doi">10.1016/0009-2797(80)90050-2</idno>
<idno type="url">https://api-v5.istex.fr/document/1878F9681122BF28A4DFC9B2DDA158A6DD4EFF8F/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001414</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001414</idno>
<idno type="wicri:Area/Istex/Curation">001414</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules</title>
<author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name>
<affiliation wicri:level="1"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name>
<affiliation wicri:level="1"><mods:affiliation>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, N1G 2W1 Canada</mods:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Safe, Lorna" sort="Safe, Lorna" uniqKey="Safe L" first="Lorna" last="Safe">Lorna Safe</name>
<affiliation wicri:level="1"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name>
<affiliation><mods:affiliation>To whom reprint requests should be sent.</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>School of Public Health, The University of Michigan, Ann Arbor, MI 48109 U.S.A.</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, The University of Michigan, Ann Arbor</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Chemico-Biological Interactions</title>
<title level="j" type="abbrev">CBI</title>
<idno type="ISSN">0009-2797</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1980">1980</date>
<biblScope unit="volume">30</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="271">271</biblScope>
<biblScope unit="page" to="285">285</biblScope>
</imprint>
<idno type="ISSN">0009-2797</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0009-2797</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>B[a]P</term>
<term>CO</term>
<term>DMAP</term>
<term>EC</term>
<term>EIC</term>
<term>GLC</term>
<term>HCBP-1</term>
<term>HCBP-2</term>
<term>HCBP-3</term>
<term>HCBP-4</term>
<term>HCBP-5</term>
<term>MC</term>
<term>PB</term>
<term>PCB</term>
<term>PCBP-1</term>
<term>PCBP-2</term>
<term>PMR</term>
<term>TCBP-1</term>
<term>TCBP-2</term>
<term>TCDF</term>
<term>TLC</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 μmol · kg−1. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo[a]pyrene (B[a]P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b5 content and the relative peak intensities and spectral shifts of the reduced microsomal cytochrome P-450: CO and ethylisocyanide (EIC) binding difference spectra. The results were compared to the effects of administering phenobarbitone (PB), 3-methylcholanthrene (MC) and PB plus MC (coadministered) to the test animals. The synthetic PCB congeners used in this study included 3,4,4′,5-tetrachlorobiphenyl (TCBP-1), 2,3′,4,4′-tetrachlorobiphenyl (TCBP-2), 2,3′,4,4′,5′-pentachlorobiphenyl (PCBP-1), 2,3,4,4′,5-pentachlorobiphenyl (PCBP-2), 2,3,3′,4,4′,5-hexachlorobiphenyl (HCBP-1), 2,3,3′,4′,5,6-hexachlorobiphenyl (HCBP-2), 2,3,3′,5,5′,6-hexachlorobiphenyl (HCBP-3), 2,2′,3,5,5′,6-hexachlorobiphenyl (HCBP-4) and 2,3,3′,4,5,5′-hexachlorobiphenyl (HCBP-5) and were used to reappraise the structure-activity rules for PCBs as hepatic microsomal enzyme inducers. The results suggested that (a) PCBs which induce MC or mixed-type activity must be substituted at both para positions, at least two meta positions but not necessarily on the same phenyl ring and can also contain one ortho chloro substituent; (b) due to the considerable structural diversity of the PB-type inducers the rules for induction of this activity by PCB congeners are not readily defined.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001414 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001414 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:1878F9681122BF28A4DFC9B2DDA158A6DD4EFF8F |texte= Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: Structure-activity rules }}
This area was generated with Dilib version V0.6.29. |