Biomedical and health studies with the new Canadian SLOWPOKE reactor
Identifieur interne : 001227 ( Istex/Curation ); précédent : 001226; suivant : 001228Biomedical and health studies with the new Canadian SLOWPOKE reactor
Auteurs : R. E. Jervis [Canada] ; R. G. V. Hancock [Canada] ; D. E. Hill [Canada] ; K. Isles [Canada]Source :
- Journal of Radioanalytical Chemistry [ 0022-4081 ] ; 1977-03-01.
Abstract
Abstract: Several features of the new SLOWPOKE+ pool-type nuclear reactor have made it very useful for instrumental neutron activation of tissues, blood and other body fluids. In this paper are reported results from studies on clinical patients who had malnutrition, cystic fibrosis and other related electrolyte disorders. Physical conditions in the irradiation sites within the beryllium reflector are such that liquids, slurries and wet tissues (the types of sample obtained from patients) can be irradiated in sealed polyethylene vials without pretreatment. This facilitates a precise semi-routine activation analysis for large numbers of samples from patients. A stable activable tracer technique has been developed to determine the extracellular fluid volume (ECV) of infants. A regulated dose of sodium bromide is injected into the patient and, following short-term equilibration and dilution of this sample, a small blood sample is taken, yielding 50 μl of plasma. The plasma bromide concentration is determined by80Br (T=18 m) activation. In order to check the accuracy of this NAA technique, some samples were cross-checked by a microdiffusion method. The technique has been applied to 230 patients and controls, and has proved to be simple, rapid, accurate and sensitive for determining ECV to ±6%. Patients with cystic fibrosis (C. F.) were studied with respect to their growth, and their sodium and electrolyte balance. In related clinical studies, hair and nail clippings from 50 C. F. patients and control children of the same age groups were activated at SLOWPOKE and Cu, Ca, Br, Cl, K, Na and I, determined for use in differentiating C. F., along with a number of other elements including Zn, Mn, Al, Ti and Ni which showed little difference. A careful analysis of the data showed that clear differentiation of all C. F. patients from controls could be achieved by comparing the values of X-factor. A fairly good correlation of hair and nail concentrations was found for a number of the elements determined, suggesting that either tissue may be used in future studies.
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DOI: 10.1007/BF02520552
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biomedical and health studies with the new Canadian SLOWPOKE reactor</title><author><name sortKey="Jervis, R E" sort="Jervis, R E" uniqKey="Jervis R" first="R. E." last="Jervis">R. E. Jervis</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, R G V" sort="Hancock, R G V" uniqKey="Hancock R" first="R. G. V." last="Hancock">R. G. V. Hancock</name><affiliation wicri:level="1"><mods:affiliation>SLOWPOKE Nuclear Reactor Facility, University of Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>SLOWPOKE Nuclear Reactor Facility, University of Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hill, D E" sort="Hill, D E" uniqKey="Hill D" first="D. E." last="Hill">D. E. Hill</name><affiliation wicri:level="1"><mods:affiliation>Hospital For Sick Children, Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital For Sick Children, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Isles, K" sort="Isles, K" uniqKey="Isles K" first="K." last="Isles">K. 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E." last="Jervis">R. E. Jervis</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hancock, R G V" sort="Hancock, R G V" uniqKey="Hancock R" first="R. G. V." last="Hancock">R. G. V. Hancock</name><affiliation wicri:level="1"><mods:affiliation>SLOWPOKE Nuclear Reactor Facility, University of Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>SLOWPOKE Nuclear Reactor Facility, University of Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Hill, D E" sort="Hill, D E" uniqKey="Hill D" first="D. E." last="Hill">D. E. Hill</name><affiliation wicri:level="1"><mods:affiliation>Hospital For Sick Children, Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital For Sick Children, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Isles, K" sort="Isles, K" uniqKey="Isles K" first="K." last="Isles">K. Isles</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dept. of Chemical Engineering and Applied Chemistry, University of Toronto</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Radioanalytical Chemistry</title><title level="j" type="sub">International Journal dealing with all aspects of nuclear analytical methods</title><title level="j" type="abbrev">J. Radioanal. Chem.</title><idno type="ISSN">0022-4081</idno><idno type="eISSN">1588-2780</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1977-03-01">1977-03-01</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="463">463</biblScope><biblScope unit="page" to="471">471</biblScope></imprint><idno type="ISSN">0022-4081</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-4081</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Several features of the new SLOWPOKE+ pool-type nuclear reactor have made it very useful for instrumental neutron activation of tissues, blood and other body fluids. In this paper are reported results from studies on clinical patients who had malnutrition, cystic fibrosis and other related electrolyte disorders. Physical conditions in the irradiation sites within the beryllium reflector are such that liquids, slurries and wet tissues (the types of sample obtained from patients) can be irradiated in sealed polyethylene vials without pretreatment. This facilitates a precise semi-routine activation analysis for large numbers of samples from patients. A stable activable tracer technique has been developed to determine the extracellular fluid volume (ECV) of infants. A regulated dose of sodium bromide is injected into the patient and, following short-term equilibration and dilution of this sample, a small blood sample is taken, yielding 50 μl of plasma. The plasma bromide concentration is determined by80Br (T=18 m) activation. In order to check the accuracy of this NAA technique, some samples were cross-checked by a microdiffusion method. The technique has been applied to 230 patients and controls, and has proved to be simple, rapid, accurate and sensitive for determining ECV to ±6%. Patients with cystic fibrosis (C. F.) were studied with respect to their growth, and their sodium and electrolyte balance. In related clinical studies, hair and nail clippings from 50 C. F. patients and control children of the same age groups were activated at SLOWPOKE and Cu, Ca, Br, Cl, K, Na and I, determined for use in differentiating C. F., along with a number of other elements including Zn, Mn, Al, Ti and Ni which showed little difference. A careful analysis of the data showed that clear differentiation of all C. F. patients from controls could be achieved by comparing the values of X-factor. A fairly good correlation of hair and nail concentrations was found for a number of the elements determined, suggesting that either tissue may be used in future studies.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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