La maladie de Parkinson au Canada (serveur d'exploration)

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Changes in hippocampal monoamine concentration following halothane anesthesia and concussion

Identifieur interne : 000190 ( Istex/Curation ); précédent : 000189; suivant : 000191

Changes in hippocampal monoamine concentration following halothane anesthesia and concussion

Auteurs : Gerald Eschun [Canada] ; Dwight Parkinson [Canada] ; Jerry Vriend [Canada]

Source :

RBID : ISTEX:CE8FEFEAAEE904570CF864F541BFA3AE486006F0

Abstract

The concentration of norepinephrine in the hippocampus of rats anesthetized with halothane (Wyeth-Ayerst, Philadelphia, Pa) is found to be markedly increased, presumably due to the stress of handling and administering the anesthetic. This increased norepinephrine concentration persists for about 50 minutes but is obliterated when the anesthetized rat is concussed. This 50-minute period corresponds to the time it takes for a rat (or human), comatose for 1–2 seconds following concussion, to regain normal memory. No changes in 3,4-dihydroxybenzeneacetic acid (DOPAC), 3-(3,4-dihydroxyphenyl) alanine (L-DOPA), and 3,4-dihydroxybenzylamine (DHBA) were noted. 5Hydroxy indole acetic acid (HIAA) showed a depression at 5 minutes and again at 30 minutes, changes that were consistent but not considered statistically significant.

Url:
DOI: 10.1016/0090-3019(92)90184-O

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ISTEX:CE8FEFEAAEE904570CF864F541BFA3AE486006F0

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