Neuropathological changes in essential tremor: 33 cases compared with 21 controls
Identifieur interne : 002A33 ( Istex/Corpus ); précédent : 002A32; suivant : 002A34Neuropathological changes in essential tremor: 33 cases compared with 21 controls
Auteurs : Elan D. Louis ; Phyllis L. Faust ; Jean-Paul G. Vonsattel ; Lawrence S. Honig ; Alex Rajput ; Christopher A. Robinson ; Ali Rajput ; Rajesh Pahwa ; Kelly E. Lyons ; G. Webster Ross ; Sarah Borden ; Carol B. Moskowitz ; Arlene Lawton ; Nora HernandezSource :
- Brain [ 0006-8950 ] ; 2007-12.
Abstract
Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.
Url:
DOI: 10.1093/brain/awm266
Links to Exploration step
ISTEX:B491903157F479B42E2DDE60E0C57B54A3F3B547Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: EDL2@columbia.edu</mods:affiliation></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G." last="Vonsattel">Jean-Paul G. Vonsattel</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Honig, Lawrence S" sort="Honig, Lawrence S" uniqKey="Honig L" first="Lawrence S." last="Honig">Lawrence S. Honig</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A." last="Robinson">Christopher A. Robinson</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Ali" sort="Rajput, Ali" uniqKey="Rajput A" first="Ali" last="Rajput">Ali Rajput</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Borden, Sarah" sort="Borden, Sarah" uniqKey="Borden S" first="Sarah" last="Borden">Sarah Borden</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Moskowitz, Carol B" sort="Moskowitz, Carol B" uniqKey="Moskowitz C" first="Carol B." last="Moskowitz">Carol B. Moskowitz</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Lawton, Arlene" sort="Lawton, Arlene" uniqKey="Lawton A" first="Arlene" last="Lawton">Arlene Lawton</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Hernandez, Nora" sort="Hernandez, Nora" uniqKey="Hernandez N" first="Nora" last="Hernandez">Nora Hernandez</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B491903157F479B42E2DDE60E0C57B54A3F3B547</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1093/brain/awm266</idno><idno type="url">https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002A33</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002A33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: EDL2@columbia.edu</mods:affiliation></affiliation></author><author><name sortKey="Faust, Phyllis L" sort="Faust, Phyllis L" uniqKey="Faust P" first="Phyllis L." last="Faust">Phyllis L. Faust</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Vonsattel, Jean Paul G" sort="Vonsattel, Jean Paul G" uniqKey="Vonsattel J" first="Jean-Paul G." last="Vonsattel">Jean-Paul G. Vonsattel</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Honig, Lawrence S" sort="Honig, Lawrence S" uniqKey="Honig L" first="Lawrence S." last="Honig">Lawrence S. Honig</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A." last="Robinson">Christopher A. Robinson</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Ali" sort="Rajput, Ali" uniqKey="Rajput A" first="Ali" last="Rajput">Ali Rajput</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly E." last="Lyons">Kelly E. Lyons</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Borden, Sarah" sort="Borden, Sarah" uniqKey="Borden S" first="Sarah" last="Borden">Sarah Borden</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Moskowitz, Carol B" sort="Moskowitz, Carol B" uniqKey="Moskowitz C" first="Carol B." last="Moskowitz">Carol B. Moskowitz</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Lawton, Arlene" sort="Lawton, Arlene" uniqKey="Lawton A" first="Arlene" last="Lawton">Arlene Lawton</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author><author><name sortKey="Hernandez, Nora" sort="Hernandez, Nora" uniqKey="Hernandez N" first="Nora" last="Hernandez">Nora Hernandez</name><affiliation><mods:affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2007-12">2007-12</date><biblScope unit="volume">130</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="3297">3297</biblScope><biblScope unit="page" to="3307">3307</biblScope></imprint><idno type="ISSN">0006-8950</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Elan D. Louis</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string><json:string>E-mail: EDL2@columbia.edu</json:string></affiliations></json:item><json:item><name>Phyllis L. Faust</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Jean-Paul G. Vonsattel</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Lawrence S. Honig</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Alex Rajput</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Christopher A. Robinson</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Ali Rajput</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Rajesh Pahwa</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Kelly E. Lyons</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>G.Webster Ross</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Sarah Borden</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Carol B. Moskowitz</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Arlene Lawton</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item><json:item><name>Nora Hernandez</name><affiliations><json:string>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</json:string></affiliations></json:item></author><subject><json:item><value>Original Articles</value></json:item><json:item><value>essential tremor</value></json:item><json:item><value>cerebellum</value></json:item><json:item><value>Purkinje cell</value></json:item><json:item><value>Lewy body</value></json:item><json:item><value>neurodegeneration</value></json:item><json:item><value>locus ceruleus</value></json:item></subject><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P > 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P > 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.</abstract><qualityIndicators><score>10</score><pdfWordCount>8162</pdfWordCount><pdfCharCount>50379</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>613 x 791 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>263</abstractWordCount><abstractCharCount>1651</abstractCharCount><keywordCount>7</keywordCount></qualityIndicators><title>Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title><genre><json:string>research-article</json:string></genre><host><title>Brain</title><language><json:string>unknown</json:string></language><issn><json:string>0006-8950</json:string></issn><eissn><json:string>1460-2156</json:string></eissn><publisherId><json:string>brainj</json:string></publisherId><volume>130</volume><issue>12</issue><pages><first>3297</first><last>3307</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1093/brain/awm266</json:string></doi><id>B491903157F479B42E2DDE60E0C57B54A3F3B547</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</p></availability><date>2007-11-19</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Elan D.</forename><surname>Louis</surname></persName><email>EDL2@columbia.edu</email><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Phyllis L.</forename><surname>Faust</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Jean-Paul G.</forename><surname>Vonsattel</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Lawrence S.</forename><surname>Honig</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Alex</forename><surname>Rajput</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Christopher A.</forename><surname>Robinson</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Ali</forename><surname>Rajput</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Rajesh</forename><surname>Pahwa</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0008"><persName><forename type="first">Kelly E.</forename><surname>Lyons</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0009"><persName><forename type="first">G.Webster</forename><surname>Ross</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0010"><persName><forename type="first">Sarah</forename><surname>Borden</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0011"><persName><forename type="first">Carol B.</forename><surname>Moskowitz</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0012"><persName><forename type="first">Arlene</forename><surname>Lawton</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><author xml:id="author-0013"><persName><forename type="first">Nora</forename><surname>Hernandez</surname></persName><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation></author><idno type="istex">B491903157F479B42E2DDE60E0C57B54A3F3B547</idno><idno type="DOI">10.1093/brain/awm266</idno></analytic><monogr><title level="j">Brain</title><idno type="pISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><idno type="PublisherID">brainj</idno><idno type="PublisherID-hwp">brain</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2007-12"></date><biblScope unit="volume">130</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="3297">3297</biblScope><biblScope unit="page" to="3307">3307</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007-11-19</date></creation><abstract><p>Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Original Articles</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>essential tremor</term></item><item><term>cerebellum</term></item><item><term>Purkinje cell</term></item><item><term>Lewy body</term></item><item><term>neurodegeneration</term></item><item><term>locus ceruleus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-11-19">Created</change><change when="2007-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-title>Brain</journal-title><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/brain/awm266</article-id><article-categories><subj-group><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Neuropathological changes in essential tremor: 33 cases compared with 21 controls</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Louis</surname><given-names>Elan D.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF1"><sup>2</sup></xref><xref ref-type="aff" rid="AFF1"><sup>3</sup></xref><xref ref-type="aff" rid="AFF1"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Faust</surname><given-names>Phyllis L.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vonsattel</surname><given-names>Jean-Paul G.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>3</sup></xref><xref ref-type="aff" rid="AFF1"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Honig</surname><given-names>Lawrence S.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF1"><sup>2</sup></xref><xref ref-type="aff" rid="AFF1"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rajput</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="AFF1"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rajput</surname><given-names>Ali</given-names></name><xref ref-type="aff" rid="AFF1"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pahwa</surname><given-names>Rajesh</given-names></name><xref ref-type="aff" rid="AFF1"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lyons</surname><given-names>Kelly E.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>G.Webster</given-names></name><xref ref-type="aff" rid="AFF1"><sup>8</sup></xref><xref ref-type="aff" rid="AFF1"><sup>9</sup></xref><xref ref-type="aff" rid="AFF1"><sup>10</sup></xref><xref ref-type="aff" rid="AFF1"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Borden</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moskowitz</surname><given-names>Carol B.</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lawton</surname><given-names>Arlene</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="AFF1"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hernandez</surname><given-names>Nora</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref></contrib></contrib-group><aff id="AFF1"><sup>1</sup>GH Sergievsky Center, <sup>2</sup>Department of Neurology, <sup>3</sup>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, <sup>4</sup>Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, <sup>5</sup>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, <sup>6</sup>Royal University Hospital, Saskatoon, Saskatchewan, Canada, <sup>7</sup>Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, <sup>8</sup>Veterans Affairs Pacific Islands Health Care System, <sup>9</sup>Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, <sup>10</sup>Pacific Health Research Institute and <sup>11</sup>Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</aff><author-notes><corresp>Correspondence to: Dr Elan Louis, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032, USA E-mail: <email>EDL2@columbia.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>19</day><month>11</month><year>2007</year></pub-date><volume>130</volume><issue>12</issue><fpage>3297</fpage><lpage>3307</lpage><history><date date-type="received"><day>25</day><month>5</month><year>2007</year></date><date date-type="rev-recd"><day>9</day><month>10</month><year>2007</year></date><date date-type="accepted"><day>11</day><month>10</month><year>2007</year></date></history><copyright-statement>© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2007</copyright-year><abstract><p>Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, <italic>P</italic> < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, <italic>P</italic> < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.</p></abstract><kwd-group><kwd>essential tremor</kwd><kwd>cerebellum</kwd><kwd>Purkinje cell</kwd><kwd>Lewy body</kwd><kwd>neurodegeneration</kwd><kwd>locus ceruleus</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Neuropathological changes in essential tremor: 33 cases compared with 21 controls</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Elan D.</namePart><namePart type="family">Louis</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><affiliation>E-mail: EDL2@columbia.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Phyllis L.</namePart><namePart type="family">Faust</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Paul G.</namePart><namePart type="family">Vonsattel</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lawrence S.</namePart><namePart type="family">Honig</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alex</namePart><namePart type="family">Rajput</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christopher A.</namePart><namePart type="family">Robinson</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ali</namePart><namePart type="family">Rajput</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rajesh</namePart><namePart type="family">Pahwa</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kelly E.</namePart><namePart type="family">Lyons</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.Webster</namePart><namePart type="family">Ross</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sarah</namePart><namePart type="family">Borden</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carol B.</namePart><namePart type="family">Moskowitz</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arlene</namePart><namePart type="family">Lawton</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nora</namePart><namePart type="family">Hernandez</namePart><affiliation>GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA, Royal University Hospital, Saskatoon, Saskatchewan, Canada, Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA, Veterans Affairs Pacific Islands Health Care System, Departments of Medicine and Geriatrics, University of Hawaii John A. Burns School of Medicine, Pacific Health Research Institute and Kuakini Medical Center/Honolulu-Asia Aging Study, Honolulu, HI, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Original Articles</topic></subject><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2007-12</dateIssued><dateCreated encoding="w3cdtf">2007-11-19</dateCreated><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.</abstract><subject><genre>keywords</genre><topic>essential tremor</topic><topic>cerebellum</topic><topic>Purkinje cell</topic><topic>Lewy body</topic><topic>neurodegeneration</topic><topic>locus ceruleus</topic></subject><relatedItem type="host"><titleInfo><title>Brain</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0006-8950</identifier><identifier type="eISSN">1460-2156</identifier><identifier type="PublisherID">brainj</identifier><identifier type="PublisherID-hwp">brain</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>130</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>3297</start><end>3307</end></extent></part></relatedItem><identifier type="istex">B491903157F479B42E2DDE60E0C57B54A3F3B547</identifier><identifier type="DOI">10.1093/brain/awm266</identifier><accessCondition type="use and reproduction" contentType="copyright">© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/covers/tiff</uri></json:item><json:item><extension>html</extension><original>true</original><mimetype>text/html</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/covers/html</uri></json:item></covers><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/annexes/jpeg</uri></json:item><json:item><extension>gif</extension><original>true</original><mimetype>image/gif</mimetype><uri>https://api-v5.istex.fr/document/B491903157F479B42E2DDE60E0C57B54A3F3B547/annexes/gif</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002A33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:B491903157F479B42E2DDE60E0C57B54A3F3B547
|texte= Neuropathological changes in essential tremor: 33 cases compared with 21 controls
}}
| This area was generated with Dilib version V0.6.29. |  |