Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants
Identifieur interne : 002A28 ( Istex/Corpus ); précédent : 002A27; suivant : 002A29Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants
Auteurs : Joshua R. Buser ; Jennifer Maire ; Art Riddle ; Xi Gong ; Thuan Nguyen ; Kerst Nelson ; Ning Ling Luo ; Jennifer Ren ; Jaime Struve ; Larry S. Sherman ; Steven P. Miller ; Vann Chau ; Glenda Hendson ; Praveen Ballabh ; Marjorie R. Grafe ; Stephen A. BackSource :
- Annals of Neurology [ 0364-5134 ] ; 2012-01.
Abstract
The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.
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DOI: 10.1002/ana.22627
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Buser</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Maire, Jennifer" sort="Maire, Jennifer" uniqKey="Maire J" first="Jennifer" last="Maire">Jennifer Maire</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Riddle, Art" sort="Riddle, Art" uniqKey="Riddle A" first="Art" last="Riddle">Art Riddle</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Gong, Xi" sort="Gong, Xi" uniqKey="Gong X" first="Xi" last="Gong">Xi Gong</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Nguyen, Thuan" sort="Nguyen, Thuan" uniqKey="Nguyen T" first="Thuan" last="Nguyen">Thuan Nguyen</name><affiliation><mods:affiliation>Preventive Medicine, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Nelson, Kerst" sort="Nelson, Kerst" uniqKey="Nelson K" first="Kerst" last="Nelson">Kerst Nelson</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Luo, Ning Ling" sort="Luo, Ning Ling" uniqKey="Luo N" first="Ning Ling" last="Luo">Ning Ling Luo</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Ren, Jennifer" sort="Ren, Jennifer" uniqKey="Ren J" first="Jennifer" last="Ren">Jennifer Ren</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Struve, Jaime" sort="Struve, Jaime" uniqKey="Struve J" first="Jaime" last="Struve">Jaime Struve</name><affiliation><mods:affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</mods:affiliation></affiliation></author><author><name sortKey="Sherman, Larry S" sort="Sherman, Larry S" uniqKey="Sherman L" first="Larry S." last="Sherman">Larry S. 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Buser</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Maire, Jennifer" sort="Maire, Jennifer" uniqKey="Maire J" first="Jennifer" last="Maire">Jennifer Maire</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Riddle, Art" sort="Riddle, Art" uniqKey="Riddle A" first="Art" last="Riddle">Art Riddle</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Gong, Xi" sort="Gong, Xi" uniqKey="Gong X" first="Xi" last="Gong">Xi Gong</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Nguyen, Thuan" sort="Nguyen, Thuan" uniqKey="Nguyen T" first="Thuan" last="Nguyen">Thuan Nguyen</name><affiliation><mods:affiliation>Preventive Medicine, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Nelson, Kerst" sort="Nelson, Kerst" uniqKey="Nelson K" first="Kerst" last="Nelson">Kerst Nelson</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Luo, Ning Ling" sort="Luo, Ning Ling" uniqKey="Luo N" first="Ning Ling" last="Luo">Ning Ling Luo</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Ren, Jennifer" sort="Ren, Jennifer" uniqKey="Ren J" first="Jennifer" last="Ren">Jennifer Ren</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Struve, Jaime" sort="Struve, Jaime" uniqKey="Struve J" first="Jaime" last="Struve">Jaime Struve</name><affiliation><mods:affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</mods:affiliation></affiliation></author><author><name sortKey="Sherman, Larry S" sort="Sherman, Larry S" uniqKey="Sherman L" first="Larry S." last="Sherman">Larry S. Sherman</name><affiliation><mods:affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</mods:affiliation></affiliation></author><author><name sortKey="Miller, Steven P" sort="Miller, Steven P" uniqKey="Miller S" first="Steven P." last="Miller">Steven P. Miller</name><affiliation><mods:affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Chau, Vann" sort="Chau, Vann" uniqKey="Chau V" first="Vann" last="Chau">Vann Chau</name><affiliation><mods:affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hendson, Glenda" sort="Hendson, Glenda" uniqKey="Hendson G" first="Glenda" last="Hendson">Glenda Hendson</name><affiliation><mods:affiliation>Pathology, University of British Columbia, Vancouver, BC, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ballabh, Praveen" sort="Ballabh, Praveen" uniqKey="Ballabh P" first="Praveen" last="Ballabh">Praveen Ballabh</name><affiliation><mods:affiliation>Departments of Pediatrics, New York Medical College, Valhalla, NY</mods:affiliation></affiliation><affiliation><mods:affiliation>Anatomy and Cell Biology, New York Medical College, Valhalla, NY</mods:affiliation></affiliation></author><author><name sortKey="Grafe, Marjorie R" sort="Grafe, Marjorie R" uniqKey="Grafe M" first="Marjorie R." last="Grafe">Marjorie R. Grafe</name><affiliation><mods:affiliation>Departments of Public Health and Pathology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation></author><author><name sortKey="Back, Stephen A" sort="Back, Stephen A" uniqKey="Back S" first="Stephen A." last="Back">Stephen A. Back</name><affiliation><mods:affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology, Oregon Health and Science University, Portland, OR</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatrics, Mail Code L481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239‐3098</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-01">2012-01</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="93">93</biblScope><biblScope unit="page" to="109">109</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">14F3C9DB140E18F2C7CA49EB99AF20179071F320</idno><idno type="DOI">10.1002/ana.22627</idno><idno type="ArticleID">ANA22627</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Joshua R. 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Sherman PhD</name><affiliations><json:string>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</json:string></affiliations></json:item><json:item><name>Steven P. Miller MDCM</name><affiliations><json:string>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>Vann Chau MD</name><affiliations><json:string>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>Glenda Hendson MD</name><affiliations><json:string>Pathology, University of British Columbia, Vancouver, BC, Canada</json:string></affiliations></json:item><json:item><name>Praveen Ballabh MD</name><affiliations><json:string>Departments of Pediatrics, New York Medical College, Valhalla, NY</json:string><json:string>Anatomy and Cell Biology, New York Medical College, Valhalla, NY</json:string></affiliations></json:item><json:item><name>Marjorie R. Grafe MD, PhD</name><affiliations><json:string>Departments of Public Health and Pathology, Oregon Health and Science University, Portland, OR</json:string></affiliations></json:item><json:item><name>Stephen A. Back MD, PhD</name><affiliations><json:string>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</json:string><json:string>Neurology, Oregon Health and Science University, Portland, OR</json:string><json:string>Department of Pediatrics, Mail Code L481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239‐3098</json:string></affiliations></json:item></author><articleId><json:string>ANA22627</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.6</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 801 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>385</abstractCharCount><pdfWordCount>8572</pdfWordCount><pdfCharCount>57668</pdfCharCount><pdfPageCount>17</pdfPageCount><abstractWordCount>50</abstractWordCount></qualityIndicators><title>Arrested preoligodendrocyte maturation contributes to 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neurosurgery</json:string></scienceMetrix></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1002/ana.22627</json:string></doi><id>14F3C9DB140E18F2C7CA49EB99AF20179071F320</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/14F3C9DB140E18F2C7CA49EB99AF20179071F320/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/14F3C9DB140E18F2C7CA49EB99AF20179071F320/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/14F3C9DB140E18F2C7CA49EB99AF20179071F320/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2011 American Neurological Association</p></availability><date>2012</date></publicationStmt><notesStmt><note>NIH</note><note>National Institutes of Neurological Diseases and Stroke - No. 1RO1NS054044; No. R37NS045737‐06S1/06S2; No. 1F30NS066704;</note><note>Bugher Award from the American Heart Association</note><note>March of Dimes Birth Defects Foundation</note><note>Canada Research Chair in Neonatal Neuroscience</note><note>Michael Smith Foundation for Health Research Scholar award</note><note>Canadian Institutes of Health Research Clinician Scientist award</note><note>NIH - No. R01NS071263;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants</title><author xml:id="author-1"><persName><forename type="first">Joshua R.</forename><surname>Buser</surname></persName><roleName type="degree">BS</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-2"><persName><forename type="first">Jennifer</forename><surname>Maire</surname></persName><roleName type="degree">BS</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-3"><persName><forename type="first">Art</forename><surname>Riddle</surname></persName><roleName type="degree">PhD</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-4"><persName><forename type="first">Xi</forename><surname>Gong</surname></persName><roleName type="degree">MD</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-5"><persName><forename type="first">Thuan</forename><surname>Nguyen</surname></persName><roleName type="degree">PhD</roleName><affiliation>Preventive Medicine, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-6"><persName><forename type="first">Kerst</forename><surname>Nelson</surname></persName><roleName type="degree">BA</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-7"><persName><forename type="first">Ning Ling</forename><surname>Luo</surname></persName><roleName type="degree">MD</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-8"><persName><forename type="first">Jennifer</forename><surname>Ren</surname></persName><roleName type="degree">BS</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-9"><persName><forename type="first">Jaime</forename><surname>Struve</surname></persName><roleName type="degree">BS</roleName><affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</affiliation></author><author xml:id="author-10"><persName><forename type="first">Larry S.</forename><surname>Sherman</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</affiliation></author><author xml:id="author-11"><persName><forename type="first">Steven P.</forename><surname>Miller</surname></persName><roleName type="degree">MDCM</roleName><affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</affiliation></author><author xml:id="author-12"><persName><forename type="first">Vann</forename><surname>Chau</surname></persName><roleName type="degree">MD</roleName><affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</affiliation></author><author xml:id="author-13"><persName><forename type="first">Glenda</forename><surname>Hendson</surname></persName><roleName type="degree">MD</roleName><affiliation>Pathology, University of British Columbia, Vancouver, BC, Canada</affiliation></author><author xml:id="author-14"><persName><forename type="first">Praveen</forename><surname>Ballabh</surname></persName><roleName type="degree">MD</roleName><affiliation>Departments of Pediatrics, New York Medical College, Valhalla, NY</affiliation><affiliation>Anatomy and Cell Biology, New York Medical College, Valhalla, NY</affiliation></author><author xml:id="author-15"><persName><forename type="first">Marjorie R.</forename><surname>Grafe</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Departments of Public Health and Pathology, Oregon Health and Science University, Portland, OR</affiliation></author><author xml:id="author-16"><persName><forename type="first">Stephen A.</forename><surname>Back</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><affiliation>Neurology, Oregon Health and Science University, Portland, OR</affiliation><affiliation>Department of Pediatrics, Mail Code L481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239‐3098</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-01"></date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="93">93</biblScope><biblScope unit="page" to="109">109</biblScope></imprint></monogr><idno type="istex">14F3C9DB140E18F2C7CA49EB99AF20179071F320</idno><idno type="DOI">10.1002/ana.22627</idno><idno type="ArticleID">ANA22627</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.</p></abstract><abstract><p>A retrospective autopsy series (1983–2000) was selected for cases with diffuse WMI and analyzed relative to prospectively collected contemporary cases (2003–2010). Controls were age‐ and region‐matched to address regional variation in preOL maturation. Successive oligodendrocyte stages were analyzed with lineage‐specific markers. Microscopic necrosis was quantified with microglial markers. Axon injury markers defined the burden of axonopathy. Extracellular matrix remodeling was defined by detection of hyaluronic acid (HA), an inhibitor of preOL maturation, and the HA receptor, CD44.</p></abstract><abstract><p>In the contemporary case series, diffuse WMI was accompanied by a significant reduction in the burden of microscopic necrosis and axonopathy. Diffuse astrogliosis extended into the lesion surround with elevated HA and astrocyte‐expressed CD44. The total population of OL lineage stages was significantly increased in lesions. This increase coincided with significant expansion of the preOL pool.</p></abstract><abstract><p>Although these data confirm that microscopic necrosis occurs in contemporary cases, the markedly decreased burden supports that it does not contribute substantially to myelination failure. The primary mechanism of myelination failure involves a disrupted cellular response whereby preOLs fail to differentiate in diffuse astrogliotic lesions. PreOL maturation arrest converts chronic WMI to a more immature state related to the burden of astrogliosis. ANN NEUROL 2012;71:93–109</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-07-07">Received</change><change when="2011-08-16">Registration</change><change when="2012-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/14F3C9DB140E18F2C7CA49EB99AF20179071F320/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/ana.v71.1</doi><numberingGroup><numbering type="journalVolume" number="71">71</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2012-01">January 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="150" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ana.22627</doi><idGroup><id type="unit" value="ANA22627"></id></idGroup><countGroup><count type="pageTotal" number="17"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2011 American Neurological Association</copyright><eventGroup><event type="manuscriptReceived" date="2011-07-07"></event><event type="manuscriptRevised" date="2011-08-11"></event><event type="manuscriptAccepted" date="2011-08-16"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-24"></event><event type="publishedOnlineAccepted" date="2011-09-12"></event><event type="firstOnline" date="2012-01-24"></event><event type="publishedOnlineFinalForm" date="2012-01-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">93</numbering><numbering type="pageLast">109</numbering></numberingGroup><correspondenceTo>Department of Pediatrics, Mail Code L481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239‐3098</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA22627.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="7"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="48"></count><count type="wordTotal" number="11307"></count></countGroup><titleGroup><title type="main" xml:lang="en">Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants</title><title type="short" xml:lang="en">Myelination Failure in WMI</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Joshua R.</givenNames><familyName>Buser</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jennifer</givenNames><familyName>Maire</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Art</givenNames><familyName>Riddle</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Xi</givenNames><familyName>Gong</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Thuan</givenNames><familyName>Nguyen</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kerst</givenNames><familyName>Nelson</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ning Ling</givenNames><familyName>Luo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jennifer</givenNames><familyName>Ren</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jaime</givenNames><familyName>Struve</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Larry S.</givenNames><familyName>Sherman</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Steven P.</givenNames><familyName>Miller</familyName><degrees>MDCM</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Vann</givenNames><familyName>Chau</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Glenda</givenNames><familyName>Hendson</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af6 #af7"><personName><givenNames>Praveen</givenNames><familyName>Ballabh</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Marjorie R.</givenNames><familyName>Grafe</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af1 #af9" corresponding="yes"><personName><givenNames>Stephen A.</givenNames><familyName>Back</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>Backs@ohsu.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Preventive Medicine, Oregon Health and Science University, Portland, OR</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CA" type="organization"><unparsedAffiliation>Pathology, University of British Columbia, Vancouver, BC, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Departments of Pediatrics, New York Medical College, Valhalla, NY</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>Anatomy and Cell Biology, New York Medical College, Valhalla, NY</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="US" type="organization"><unparsedAffiliation>Departments of Public Health and Pathology, Oregon Health and Science University, Portland, OR</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="US" type="organization"><unparsedAffiliation>Neurology, Oregon Health and Science University, Portland, OR</unparsedAffiliation></affiliation></affiliationGroup><fundingInfo><fundingAgency>NIH</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Institutes of Neurological Diseases and Stroke</fundingAgency><fundingNumber>1RO1NS054044</fundingNumber><fundingNumber>R37NS045737‐06S1/06S2</fundingNumber><fundingNumber>1F30NS066704</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Bugher Award from the American Heart Association</fundingAgency></fundingInfo><fundingInfo><fundingAgency>March of Dimes Birth Defects Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Canada Research Chair in Neonatal Neuroscience</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Michael Smith Foundation for Health Research Scholar award</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Canadian Institutes of Health Research Clinician Scientist award</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>R01NS071263</fundingNumber></fundingInfo><supportingInformation><p> Additional supporting information can be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig1"></mediaResource><caption>Supporting Information Figure 1</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig2"></mediaResource><caption>Supporting Information Figure 2</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig3"></mediaResource><caption>Supporting Information Figure 3</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig4"></mediaResource><caption>Supporting Information Figure 4</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig5"></mediaResource><caption>Supporting Information Figure 5</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig6"></mediaResource><caption>Supporting Information Figure 6</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppFig7"></mediaResource><caption>Supporting Information Figure 7</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22627:ANA_22627_sm_SuppTable1"></mediaResource><caption>Supporting Information Table 1</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective:</title><p>The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>A retrospective autopsy series (1983–2000) was selected for cases with diffuse WMI and analyzed relative to prospectively collected contemporary cases (2003–2010). Controls were age‐ and region‐matched to address regional variation in preOL maturation. Successive oligodendrocyte stages were analyzed with lineage‐specific markers. Microscopic necrosis was quantified with microglial markers. Axon injury markers defined the burden of axonopathy. Extracellular matrix remodeling was defined by detection of hyaluronic acid (HA), an inhibitor of preOL maturation, and the HA receptor, CD44.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>In the contemporary case series, diffuse WMI was accompanied by a significant reduction in the burden of microscopic necrosis and axonopathy. Diffuse astrogliosis extended into the lesion surround with elevated HA and astrocyte‐expressed CD44. The total population of OL lineage stages was significantly increased in lesions. This increase coincided with significant expansion of the preOL pool.</p></section><section xml:id="abs1-4"><title type="main">Interpretation:</title><p>Although these data confirm that microscopic necrosis occurs in contemporary cases, the markedly decreased burden supports that it does not contribute substantially to myelination failure. The primary mechanism of myelination failure involves a disrupted cellular response whereby preOLs fail to differentiate in diffuse astrogliotic lesions. PreOL maturation arrest converts chronic WMI to a more immature state related to the burden of astrogliosis. ANN NEUROL 2012;71:93–109</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Myelination Failure in WMI</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants</title></titleInfo><name type="personal"><namePart type="given">Joshua R.</namePart><namePart type="family">Buser</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer</namePart><namePart type="family">Maire</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Art</namePart><namePart type="family">Riddle</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xi</namePart><namePart type="family">Gong</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thuan</namePart><namePart type="family">Nguyen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Preventive Medicine, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kerst</namePart><namePart type="family">Nelson</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ning Ling</namePart><namePart type="family">Luo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer</namePart><namePart type="family">Ren</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaime</namePart><namePart type="family">Struve</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Larry S.</namePart><namePart type="family">Sherman</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Neuroscience, Oregon National Primate Research Center, Hillsboro, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Steven P.</namePart><namePart type="family">Miller</namePart><namePart type="termsOfAddress">MDCM</namePart><affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vann</namePart><namePart type="family">Chau</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Pediatrics, University of British Columbia, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Glenda</namePart><namePart type="family">Hendson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Pathology, University of British Columbia, Vancouver, BC, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Praveen</namePart><namePart type="family">Ballabh</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Departments of Pediatrics, New York Medical College, Valhalla, NY</affiliation><affiliation>Anatomy and Cell Biology, New York Medical College, Valhalla, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marjorie R.</namePart><namePart type="family">Grafe</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Departments of Public Health and Pathology, Oregon Health and Science University, Portland, OR</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen A.</namePart><namePart type="family">Back</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Departments of Pediatrics, Oregon Health and Science University, Portland, OR</affiliation><affiliation>Neurology, Oregon Health and Science University, Portland, OR</affiliation><affiliation>Department of Pediatrics, Mail Code L481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239‐3098</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2012-01</dateIssued><dateCaptured encoding="w3cdtf">2011-07-07</dateCaptured><dateValid encoding="w3cdtf">2011-08-16</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">7</extent><extent unit="tables">2</extent><extent unit="references">48</extent><extent unit="words">11307</extent></physicalDescription><abstract>The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is poorly defined. We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte‐rich lesions.</abstract><abstract>A retrospective autopsy series (1983–2000) was selected for cases with diffuse WMI and analyzed relative to prospectively collected contemporary cases (2003–2010). Controls were age‐ and region‐matched to address regional variation in preOL maturation. Successive oligodendrocyte stages were analyzed with lineage‐specific markers. Microscopic necrosis was quantified with microglial markers. Axon injury markers defined the burden of axonopathy. Extracellular matrix remodeling was defined by detection of hyaluronic acid (HA), an inhibitor of preOL maturation, and the HA receptor, CD44.</abstract><abstract>In the contemporary case series, diffuse WMI was accompanied by a significant reduction in the burden of microscopic necrosis and axonopathy. Diffuse astrogliosis extended into the lesion surround with elevated HA and astrocyte‐expressed CD44. The total population of OL lineage stages was significantly increased in lesions. This increase coincided with significant expansion of the preOL pool.</abstract><abstract>Although these data confirm that microscopic necrosis occurs in contemporary cases, the markedly decreased burden supports that it does not contribute substantially to myelination failure. The primary mechanism of myelination failure involves a disrupted cellular response whereby preOLs fail to differentiate in diffuse astrogliotic lesions. PreOL maturation arrest converts chronic WMI to a more immature state related to the burden of astrogliosis. ANN NEUROL 2012;71:93–109</abstract><note type="funding">NIH</note><note type="funding">National Institutes of Neurological Diseases and Stroke - No. 1RO1NS054044; No. R37NS045737‐06S1/06S2; No. 1F30NS066704; </note><note type="funding">Bugher Award from the American Heart Association</note><note type="funding">March of Dimes Birth Defects Foundation</note><note type="funding">Canada Research Chair in Neonatal Neuroscience</note><note type="funding">Michael Smith Foundation for Health Research Scholar award</note><note type="funding">Canadian Institutes of Health Research Clinician Scientist award</note><note type="funding">NIH - No. R01NS071263; </note><relatedItem type="host"><titleInfo><title>Annals of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional supporting information can be found in the online version of this article.Supporting Info Item: Supporting Information Figure 1 - Supporting Information Figure 2 - Supporting Information Figure 3 - Supporting Information Figure 4 - Supporting Information Figure 5 - Supporting Information Figure 6 - Supporting Information Figure 7 - Supporting Information Table 1 - </note><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>93</start><end>109</end><total>17</total></extent></part></relatedItem><identifier type="istex">14F3C9DB140E18F2C7CA49EB99AF20179071F320</identifier><identifier type="DOI">10.1002/ana.22627</identifier><identifier type="ArticleID">ANA22627</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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