Myxomatous mitral valve disease and related entities: The role of matrix in valvular heart disease
Identifieur interne : 002409 ( Istex/Corpus ); précédent : 002408; suivant : 002410Myxomatous mitral valve disease and related entities: The role of matrix in valvular heart disease
Auteurs : Wanda M. LesterSource :
- Cardiovascular Pathology [ 1054-8807 ] ; 1995.
Abstract
Myxomatous mitral valve disease is a cause of prolapse of mitral valve leaflet(s) into the left atrium. In this condition there is a loss of collagen from the leaflet and an accumulation of glycosaminoglycan. Complications of myxomatous mitral valve disease include infective endocarditis, mitral regurgitation, sudden death, and stroke. Mitral valve prolapse has been reported to occur in association with many syndromes. In some of these, such as Marfan syndrome, the pathology of the mitral valve has been well described and is that of a myxomatous valve. However, in some of the other disorders associated with mitral valve prolapse, there is no information yet available on the valve pathology, and this would be useful in order to better understand the pathogenesis of myxomatous mitral valve disease.
Url:
DOI: 10.1016/1054-8807(95)00052-7
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Lester, MD, Department of Histopathology, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, T2N 2T9 Canada; telephone: (403) 670-4753, fax: (403) 670-4748.</affiliation><affiliation>Department of Pathology, Foothills Hospital and the University of Calgary, Alberta, Canada</affiliation></author><idno type="istex">EB7485855C0DBA7004352E7362ABD014CC89FF3D</idno><idno type="DOI">10.1016/1054-8807(95)00052-7</idno><idno type="PII">1054-8807(95)00052-7</idno></analytic><monogr><title level="j">Cardiovascular Pathology</title><title level="j" type="abbrev">CVP</title><idno type="pISSN">1054-8807</idno><idno type="PII">S1054-8807(00)X0004-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">4</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="264">264</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Myxomatous mitral valve disease is a cause of prolapse of mitral valve leaflet(s) into the left atrium. 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Canada, March 11–17, 1995.</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Symposium paper</ce:textfn></ce:dochead><ce:title>Myxomatous mitral valve disease and related entities: The role of matrix in valvular heart disease</ce:title><ce:author-group><ce:author><ce:given-name>Wanda M.</ce:given-name><ce:surname>Lester</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Pathology, Foothills Hospital and the University of Calgary, Alberta, Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for reprints: Wanda M. Lester, MD, Department of Histopathology, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, T2N 2T9 Canada; telephone: (403) 670-4753, fax: (403) 670-4748.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="7" month="6" year="1995"></ce:date-received><ce:date-accepted day="7" month="6" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Myxomatous mitral valve disease is a cause of prolapse of mitral valve leaflet(s) into the left atrium. In this condition there is a loss of collagen from the leaflet and an accumulation of glycosaminoglycan. Complications of myxomatous mitral valve disease include infective endocarditis, mitral regurgitation, sudden death, and stroke. Mitral valve prolapse has been reported to occur in association with many syndromes. In some of these, such as Marfan syndrome, the pathology of the mitral valve has been well described and is that of a myxomatous valve. 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Lester, MD, Department of Histopathology, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, T2N 2T9 Canada; telephone: (403) 670-4753, fax: (403) 670-4748.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Myxomatous mitral valve disease is a cause of prolapse of mitral valve leaflet(s) into the left atrium. In this condition there is a loss of collagen from the leaflet and an accumulation of glycosaminoglycan. 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