Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats
Identifieur interne : 002278 ( Istex/Corpus ); précédent : 002277; suivant : 002279Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats
Auteurs : Vemuganti L. Raghavendra Rao ; Aclan Dogan ; Kathryn G. Todd ; Kellie K. Bowen ; Robert J. DempseySource :
- Brain Research [ 0006-8993 ] ; 2001.
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Abstract
This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.
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DOI: 10.1016/S0006-8993(01)02617-8
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Raghavendra Rao</name><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author><author><name sortKey="Dogan, Aclan" sort="Dogan, Aclan" uniqKey="Dogan A" first="Aclan" last="Dogan">Aclan Dogan</name><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author><author><name sortKey="Todd, Kathryn G" sort="Todd, Kathryn G" uniqKey="Todd K" first="Kathryn G." last="Todd">Kathryn G. Todd</name><affiliation><mods:affiliation>Department of Psychiatry, University of Alberta, Edmonton, Canada</mods:affiliation></affiliation></author><author><name sortKey="Bowen, Kellie K" sort="Bowen, Kellie K" uniqKey="Bowen K" first="Kellie K." last="Bowen">Kellie K. 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Raghavendra Rao</name><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author><author><name sortKey="Dogan, Aclan" sort="Dogan, Aclan" uniqKey="Dogan A" first="Aclan" last="Dogan">Aclan Dogan</name><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author><author><name sortKey="Todd, Kathryn G" sort="Todd, Kathryn G" uniqKey="Todd K" first="Kathryn G." last="Todd">Kathryn G. Todd</name><affiliation><mods:affiliation>Department of Psychiatry, University of Alberta, Edmonton, Canada</mods:affiliation></affiliation></author><author><name sortKey="Bowen, Kellie K" sort="Bowen, Kellie K" uniqKey="Bowen K" first="Kellie K." last="Bowen">Kellie K. Bowen</name><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author><author><name sortKey="Dempsey, Robert J" sort="Dempsey, Robert J" uniqKey="Dempsey R" first="Robert J." last="Dempsey">Robert J. Dempsey</name><affiliation><mods:affiliation>E-mail: dempsey@neurosurg.wisc.edu</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">911</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="96">96</biblScope><biblScope unit="page" to="100">100</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disorders of the nervous system</term><term>Excitotoxicity</term><term>Glutamate antagonist</term><term>Memantine</term><term>Neuroprotection</term><term>Secondary neuronal death</term><term>Traumatic brain injury</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Vemuganti L. Raghavendra Rao</name><affiliations><json:string>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</json:string></affiliations></json:item><json:item><name>Aclan Dogan</name><affiliations><json:string>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</json:string></affiliations></json:item><json:item><name>Kathryn G. Todd</name><affiliations><json:string>Department of Psychiatry, University of Alberta, Edmonton, Canada</json:string></affiliations></json:item><json:item><name>Kellie K. Bowen</name><affiliations><json:string>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</json:string></affiliations></json:item><json:item><name>Robert J. Dempsey</name><affiliations><json:string>E-mail: dempsey@neurosurg.wisc.edu</json:string><json:string>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Disorders of the nervous system : Trauma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Excitotoxicity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Glutamate antagonist</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memantine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Neuroprotection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Secondary neuronal death</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Traumatic brain injury</value></json:item></subject><articleId><json:string>30293</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. 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CCI injury in the saline injected group resulted in significant neuronal loss in the CA2 and CA3 regions (B and b). Memantine treatment significantly prevented the CCI injury induced neuronal death in both the CA2 and CA3 regions (C and c). The scale bar is 250 μm (A, B and C) and 100 μm (a, b and c). The figure shows representative sections from each group. The mean±S.D. (n of 8 per group) of neuronal numbers are given in Table 1.</note><note type="content">Table 1: Memantine treatment decreases hippocampal neuronal loss and cortical damage after CCI injury</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats</title><author xml:id="author-0000"><persName><forename type="first">Vemuganti L.</forename><surname>Raghavendra Rao</surname></persName><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Aclan</forename><surname>Dogan</surname></persName><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Kathryn G.</forename><surname>Todd</surname></persName><affiliation>Department of Psychiatry, University of Alberta, Edmonton, Canada</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kellie K.</forename><surname>Bowen</surname></persName><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Robert J.</forename><surname>Dempsey</surname></persName><email>dempsey@neurosurg.wisc.edu</email><note type="correspondence"><p>Corresponding author. Tel.: +1-608-263-9585; fax: +1-608-263-1728</p></note><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation></author><idno type="istex">8E93AB05D40BD176D2BA03D4BDBE65951F33CCE4</idno><idno type="DOI">10.1016/S0006-8993(01)02617-8</idno><idno type="PII">S0006-8993(01)02617-8</idno><idno type="ArticleID">30293</idno></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X0333-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">911</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="96">96</biblScope><biblScope unit="page" to="100">100</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><item><term>Disorders of the nervous system</term><term>Trauma</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Excitotoxicity</term></item><item><term>Glutamate antagonist</term></item><item><term>Memantine</term></item><item><term>Neuroprotection</term></item><item><term>Secondary neuronal death</term></item><item><term>Traumatic brain injury</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/8E93AB05D40BD176D2BA03D4BDBE65951F33CCE4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="GR1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco" xml:lang="en"><item-info><jid>BRES</jid><aid>30293</aid><ce:pii>S0006-8993(01)02617-8</ce:pii><ce:doi>10.1016/S0006-8993(01)02617-8</ce:doi><ce:copyright type="full-transfer" year="2001">Elsevier Science B.V.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats</ce:title><ce:author-group><ce:author><ce:given-name>Vemuganti L.</ce:given-name><ce:surname>Raghavendra Rao</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Aclan</ce:given-name><ce:surname>Dogan</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kathryn G.</ce:given-name><ce:surname>Todd</ce:surname><ce:cross-ref refid="AFF4"><ce:sup loc="post">d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kellie K.</ce:given-name><ce:surname>Bowen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Robert J.</ce:given-name><ce:surname>Dempsey</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup loc="post">c</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1">∗</ce:cross-ref><ce:e-address type="email">dempsey@neurosurg.wisc.edu</ce:e-address></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Cardiovascular Research Center, University of Wisconsin-Madison, Madison, WI, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>William S. Middleton Memorial Veterans Administration Hospital, Madison, WI, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Department of Psychiatry, University of Alberta, Edmonton, Canada</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Tel.: +1-608-263-9585; fax: +1-608-263-1728</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="1" month="5" year="2001"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0025">This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="neurosci"><ce:keyword><ce:text>Disorders of the nervous system</ce:text><ce:keyword><ce:text>Trauma</ce:text></ce:keyword></ce:keyword></ce:keywords><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Excitotoxicity</ce:text></ce:keyword><ce:keyword><ce:text>Glutamate antagonist</ce:text></ce:keyword><ce:keyword><ce:text>Memantine</ce:text></ce:keyword><ce:keyword><ce:text>Neuroprotection</ce:text></ce:keyword><ce:keyword><ce:text>Secondary neuronal death</ce:text></ce:keyword><ce:keyword><ce:text>Traumatic brain injury</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats</title></titleInfo><name type="personal"><namePart type="given">Vemuganti L.</namePart><namePart type="family">Raghavendra Rao</namePart><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aclan</namePart><namePart type="family">Dogan</namePart><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn G.</namePart><namePart type="family">Todd</namePart><affiliation>Department of Psychiatry, University of Alberta, Edmonton, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kellie K.</namePart><namePart type="family">Bowen</namePart><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert J.</namePart><namePart type="family">Dempsey</namePart><affiliation>E-mail: dempsey@neurosurg.wisc.edu</affiliation><affiliation>Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA</affiliation><description>Corresponding author. Tel.: +1-608-263-9585; fax: +1-608-263-1728</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2001</dateIssued><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.</abstract><note type="content">Section title: Short communication</note><note type="content">Fig. 1: Thionine-stained brain sections showing hippocampus of rats subjected to sham-operation (A and a) and CCI injury (B, b, C and c) injected with saline (A, a, B and b) and 20 mg/Kg memantine (C and c). CCI injury in the saline injected group resulted in significant neuronal loss in the CA2 and CA3 regions (B and b). Memantine treatment significantly prevented the CCI injury induced neuronal death in both the CA2 and CA3 regions (C and c). The scale bar is 250 μm (A, B and C) and 100 μm (a, b and c). The figure shows representative sections from each group. The mean±S.D. (n of 8 per group) of neuronal numbers are given in Table 1.</note><note type="content">Table 1: Memantine treatment decreases hippocampal neuronal loss and cortical damage after CCI injury</note><subject lang="en"><topic>Disorders of the nervous system : Trauma</topic></subject><subject lang="en"><genre>Keywords</genre><topic>Excitotoxicity</topic><topic>Glutamate antagonist</topic><topic>Memantine</topic><topic>Neuroprotection</topic><topic>Secondary neuronal death</topic><topic>Traumatic brain injury</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20010817</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X0333-2</identifier><part><date>20010817</date><detail type="volume"><number>911</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>104</end></extent><extent unit="pages"><start>96</start><end>100</end></extent></part></relatedItem><identifier type="istex">8E93AB05D40BD176D2BA03D4BDBE65951F33CCE4</identifier><identifier type="DOI">10.1016/S0006-8993(01)02617-8</identifier><identifier type="PII">S0006-8993(01)02617-8</identifier><identifier type="ArticleID">30293</identifier><accessCondition type="use and reproduction" contentType="copyright">©2001 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©2001</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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